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UniProtKB/Swiss-Prot entry Q4FMH0

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HISX2_PELUB
Primary accession number Q4FMH0
Secondary accession numbers None
Integrated into Swiss-Prot on January 10, 2006
Sequence was last modified on August 30, 2005 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 26)
Name and origin of the protein
Protein name Histidinol dehydrogenase 2
Synonyms HDH 2
EC 1.1.1.23
Gene name
Name: hisD2
OrderedLocusNames: SAR11_0801
From
Pelagibacter ubique [TaxID: 335992] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales; SAR11 cluster; Candidatus Pelagibacter.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=HTCC1062;
DOI=10.1126/science.1114057; PubMed=16109880 [NCBI, ExPASy, EBI, Israel, Japan]
Giovannoni S.J., Tripp H.J., Givan S., Podar M., Vergin K.L., Baptista D., Bibbs L., Eads J., Richardson T.H., Noordewier M., Rappe M.S., Short J.M., Carrington J.C., Mathur E.J.;
"Genome streamlining in a cosmopolitan oceanic bacterium.";
Science 309:1242-1245(2005).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CP000084; AAZ21619.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_266222.1; -.
3D structure databases
ModBase Q4FMH0.
Enzyme and pathway databases
BioCyc CPEL335992:SAR11_0801-MON; -.
Ontologies
GO
GO:0004399; Molecular function: histidinol dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0000105; Biological process: histidine biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_01024; -; 1.
PBIL [Tree]
InterPro IPR001692; Histidinol_DHase.
IPR012131; Hstdl_DHase_prok.
Graphical view of domain structure.
PANTHER PTHR21256:SF2; Hstdl_DH_prok; 1.
Pfam PF00815; Histidinol_dh; 1.
Pfam graphical view of domain structure.
PRINTS PR00083; HOLDHDRGNASE.
ProDom PD002680; Histidinol_dh; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR00069; hisD; 1.
PROSITE PS00611; HISOL_DEHYDROGENASE; 1.
BLOCKS Q4FMH0.
Genome annotation databases
GeneID 3516715; -.
GenomeReviews CP000084_GR; SAR11_0801.
KEGG pub:SAR11_0801; -.
Phylogenomic databases
HOGENOM Q4FMH0; -.
Genome annotation databases
CMR Q4FMH0; SAR11_0801.
Other
ProtoNet Q4FMH0.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Complete proteome; Histidine biosynthesis; Metal-binding; NAD; Oxidoreductase; Zinc.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   428  428     Histidinol dehydrogenase 2. PRO_0000135810
ACT_SITE   320   320        Proton acceptor (By similarity). 
ACT_SITE   321   321        Proton acceptor (By similarity). 
METAL   250   250        Zinc (By similarity). 
METAL   253   253        Zinc (By similarity). 
METAL   354   354        Zinc (By similarity). 
METAL   413   413        Zinc (By similarity). 
BINDING   228   228        Substrate (By similarity). 
BINDING   250   250        Substrate (By similarity). 
BINDING   253   253        Substrate (By similarity). 
BINDING   321   321        Substrate (By similarity). 
BINDING   354   354        Substrate (By similarity). 
BINDING   408   408        Substrate (By similarity). 
BINDING   413   413        Substrate (By similarity). 
Sequence information
Length: 428 AA [This is the length of the unprocessed precursor] Molecular weight: 46658 Da [This is the MW of the unprocessed precursor] CRC64: 0DE1C63534A76B41 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MAITYLKKSP KTSSTDDTKT TGIVQDLLKN IETTKEQGCI DLTKKFDKYD GEIIVSKERI 

        70         80         90        100        110        120 
EEIKKTLDQK TKDDVQFSYE RVRKFAEAQL KNYGQDFEVE LSDGLFAGQK LIPVNTAGCY 

       130        140        150        160        170        180 
VPGGRYAHIA SAVMSVTTAK VAGVKNVIAC SPPKEGVGAH PTIIYTADLC GADVILNLGG 

       190        200        210        220        230        240 
VPAIAAMTNG LFNNPPADII VGPGNQFVAE AKRILFGKVG IDLFAGPTEI GIIADAKADP 

       250        260        270        280        290        300 
EIVAVDLVGQ AEHGYNSPCW LYTTSKELAE KVMKRVPELI AELPEVPRTN ADAAWRDYGE 

       310        320        330        340        350        360 
VILCDTDEEM ATISDEYAPE HLEVQTENLE WFHKRLTNYG SLFIGEETTV AYGDKCSGTN 

       370        380        390        400        410        420 
HILPTKGAGR YTGGLFVGKF VKTLSFQRMT KESTELVGAA AARISRYEGM EAHARTGDVR 


LKKYGYSS
Q4FMH0 in FASTA format

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