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UniProtKB/Swiss-Prot entry Q4FNE2

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HISX1_PELUB
Primary accession number Q4FNE2
Secondary accession numbers None
Integrated into Swiss-Prot on January 10, 2006
Sequence was last modified on August 30, 2005 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 26)
Name and origin of the protein
Protein name Histidinol dehydrogenase 1
Synonyms HDH 1
EC 1.1.1.23
Gene name
Name: hisD1
OrderedLocusNames: SAR11_0475
From
Pelagibacter ubique [TaxID: 335992] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales; SAR11 cluster; Candidatus Pelagibacter.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=HTCC1062;
DOI=10.1126/science.1114057; PubMed=16109880 [NCBI, ExPASy, EBI, Israel, Japan]
Giovannoni S.J., Tripp H.J., Givan S., Podar M., Vergin K.L., Baptista D., Bibbs L., Eads J., Richardson T.H., Noordewier M., Rappe M.S., Short J.M., Carrington J.C., Mathur E.J.;
"Genome streamlining in a cosmopolitan oceanic bacterium.";
Science 309:1242-1245(2005).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CP000084; AAZ21297.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_265900.1; -.
3D structure databases
ModBase Q4FNE2.
Enzyme and pathway databases
BioCyc CPEL335992:SAR11_0475-MON; -.
Ontologies
GO
GO:0004399; Molecular function: histidinol dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0000105; Biological process: histidine biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_01024; -; 1.
PBIL [Tree]
InterPro IPR001692; Histidinol_DHase.
IPR012131; Hstdl_DHase_prok.
Graphical view of domain structure.
PANTHER PTHR21256:SF2; Hstdl_DH_prok; 1.
Pfam PF00815; Histidinol_dh; 1.
Pfam graphical view of domain structure.
PRINTS PR00083; HOLDHDRGNASE.
ProDom PD002680; Histidinol_dh; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR00069; hisD; 1.
PROSITE PS00611; HISOL_DEHYDROGENASE; 1.
BLOCKS Q4FNE2.
Genome annotation databases
GeneID 3517238; -.
GenomeReviews CP000084_GR; SAR11_0475.
KEGG pub:SAR11_0475; -.
Phylogenomic databases
HOGENOM Q4FNE2; -.
Genome annotation databases
CMR Q4FNE2; SAR11_0475.
Other
ProtoNet Q4FNE2.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Complete proteome; Histidine biosynthesis; Metal-binding; NAD; Oxidoreductase; Zinc.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   428  428     Histidinol dehydrogenase 1. PRO_0000135809
ACT_SITE   324   324        Proton acceptor (By similarity). 
ACT_SITE   325   325        Proton acceptor (By similarity). 
METAL   256   256        Zinc (By similarity). 
METAL   259   259        Zinc (By similarity). 
METAL   358   358        Zinc (By similarity). 
METAL   417   417        Zinc (By similarity). 
BINDING   234   234        Substrate (By similarity). 
BINDING   256   256        Substrate (By similarity). 
BINDING   259   259        Substrate (By similarity). 
BINDING   325   325        Substrate (By similarity). 
BINDING   358   358        Substrate (By similarity). 
BINDING   412   412        Substrate (By similarity). 
BINDING   417   417        Substrate (By similarity). 
Sequence information
Length: 428 AA [This is the length of the unprocessed precursor] Molecular weight: 47310 Da [This is the MW of the unprocessed precursor] CRC64: 87F54F17177A8658 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MIKILDSKNK NFDKTLDALL SKRKNKVQLN SVSVIKIIKD VKKNGDKAIL KYEKRFNKNS 

        70         80         90        100        110        120 
IIAPSIKQIN RAIQSLDQKV KKAIDLAYDR IYKFHSLQKF KNISYTDKLK NKLEYKYVPI 

       130        140        150        160        170        180 
ESVAIYVPGS TASYPSSVLM NAVPAIVAGV KRLVMVNPGQ KGKQNPAVLY AAKKCKIKEI 

       190        200        210        220        230        240 
YSIGGPSAIA AVAYGTKKIK KVDKIIGPGN SYVAAAKKEV FGDVGIEGMI AGPSEVTIVC 

       250        260        270        280        290        300 
DKFSNPEWIA SDLIGQAEHD NLAQCILISK DKSIIKKVNY EIINQLKELP RAVIAKNSLL 

       310        320        330        340        350        360 
NNGILIYMPS DQKIINTVNK IAPEHLELNT KNYKKVVSKI KNAGSICLGK YAVMAMTDYN 

       370        380        390        400        410        420 
VGSNHVLPTN SSARYSSGVS VNEFYKRISY INLSKKGIET LGPSVITLAN YEGLVGHAKS 


VEKRIRRK
Q4FNE2 in FASTA format

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