[1]	NUCLEOTIDE SEQUENCE [MRNA]. TISSUE=Venom gland; DOI=10.1007/s00018-005-5384-9; PubMed=16261251 [NCBI, ExPASy, EBI, Israel, Japan] St Pierre L., Woods R., Earl S.T.H., Masci P.P., Lavin M.F.; "Identification and analysis of venom gland-specific genes from the coastal taipan (Oxyuranus scutellatus) and related species."; Cell. Mol. Life Sci. 62:2679-2693(2005).
[2]	FUNCTION, AND SUBUNIT. TISSUE=Venom; DOI=10.1016/0041-0101(91)90210-I; PubMed=1796476 [NCBI, ExPASy, EBI, Israel, Japan] Stiles B.G., Sexton F.W., Weinstein S.A.; "Antibacterial effects of different snake venoms: purification and characterization of antibacterial proteins from Pseudechis australis (Australian king brown or mulga snake) venom."; Toxicon 29:1129-1141(1991).

Comments

FUNCTION: Catalyzes an oxidative deamination of predominantly hydrophobic and aromatic L-amino acids. Inhibits platelet aggregation. Has an ability to induce apoptosis and hemorrhage (By similarity). Has an antibacterial activity.
CATALYTIC ACTIVITY: An L-amino acid + H₂O + O₂ = a 2-oxo acid + NH₃ + H₂O₂.
COFACTOR: FAD (By similarity).
SUBUNIT: Homodimer.
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: Expressed by the venom gland.
PTM: Glycosylated (By similarity).
SIMILARITY: Belongs to the flavin monoamine oxidase family. FIG1 subfamily.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

DQ088992; AAY89682.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

SMR

Q4JHE1; 23-504.

ModBase

Q4JHE1.

Family and domain databases

InterPro

IPR000759; Adrndx_reductase.
IPR001613; Amineoxid_fl.
IPR002937; Amino_oxidase.
Graphical view of domain structure.

Pfam

PF01593; Amino_oxidase; 1.
Pfam graphical view of domain structure.

PRINTS

PR00419; ADXRDTASE.
PR00757; AMINEOXDASEF.

BLOCKS

Q4JHE1.

Phylogenomic databases

HOVERGEN

Q4JHE1; -.

Other

ProtoNet

Q4JHE1.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Antibiotic; Antimicrobial; Apoptosis; Blood coagulation; FAD; Flavoprotein; Glycoprotein; Oxidoreductase; Secreted; Signal; Toxin.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`1 18`	`18`	`By similarity.`
`CHAIN`	`19 517`	`499`	`L-amino-acid oxidase.`	`PRO_5000140380`
`NP_BIND`	`108 109`	`2`	`FAD (By similarity).`
`NP_BIND`	`485 488`	`4`	`FAD (By similarity).`
`BINDING`	`82 82`		`FAD (By similarity).`
`BINDING`	`90 90`		`FAD (By similarity).`
`BINDING`	`109 109`		`Substrate (By similarity).`
`BINDING`	`280 280`		`FAD; via amide nitrogen and carbonyl oxygen (By similarity).`
`BINDING`	`391 391`		`Substrate (By similarity).`
`BINDING`	`476 476`		`FAD (By similarity).`
`CARBOHYD`	`191 191`		`N-linked (GlcNAc...) (Potential).`
`DISULFID`	`29 192`		`By similarity.`
`DISULFID`	`350 431`		`By similarity.`

Sequence information

Length: 517 AA [This is the length of the unprocessed precursor]

Molecular weight: 58744 Da [This is the MW of the unprocessed precursor]

CRC64: 9E0ACCD728782BE5 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MNVFFMFSLL FLAALGSCAD DRRRPLEECF READYEEFLE IAKNGLQRTS NPKRVVVVGA 

        70         80         90        100        110        120 
GMAGLSAAYV LAGAGHQVTL LEASERVGGR VNTYRNEKDG WYVNLGPMRL PERHRIIREY 

       130        140        150        160        170        180 
IRKFGLELNE FIQENDNAWY FIKNIRKRVS EVKKDPGVFK YPVKPSEEGK SASQLYRESL 

       190        200        210        220        230        240 
QKVIEELKRT NCSYILNKYD TYSTKEYLIK EGNLSPGAVD MIGDLLNEDS SYYLSFIESL 

       250        260        270        280        290        300 
KSDDIFSYEK RFDEIVGGFD QLPRSMYQAI AEKVHLNAQV IKIQQNAEDV RVTYQTPAKT 

       310        320        330        340        350        360 
LSYVIADYVI VCSTSRAARR IHFEPPLPPK KAHALRSIHY RSSTKIFLTC SQKFWEADGI 

       370        380        390        400        410        420 
HGGKSTTDLP SRFIYYPNHS FTSGIGVIVA YTLADDTDFF QALDIETSAD IVINDLSLIH 

       430        440        450        460        470        480 
QLPKEQIQAL CYPSKIQKWS LDEYAMGAIT SFTPYQFQDF FEIVAAPVGR IYFAGEYTAS 

       490        500        510 
VHGWLDSTIK SGLTAARDVN LASQKPSRIQ LSNDNEL

Q4JHE1 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools