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UniProtKB/Swiss-Prot entry Q4JW59

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HISX_CORJK
Primary accession number Q4JW59
Secondary accession numbers None
Integrated into Swiss-Prot on January 10, 2006
Sequence was last modified on August 2, 2005 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 27)
Name and origin of the protein
Protein name Histidinol dehydrogenase
Synonyms HDH
EC 1.1.1.23
Gene name
Name: hisD
OrderedLocusNames: jk0786
From
Corynebacterium jeikeium (strain K411) [TaxID: 306537] [HAMAP proteome]
Taxonomy Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; Corynebacterineae; Corynebacteriaceae; Corynebacterium.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1128/JB.187.13.4671-4682.2005; PubMed=15968079 [NCBI, ExPASy, EBI, Israel, Japan]
Tauch A., Kaiser O., Hain T., Goesmann A., Weisshaar B., Albersmeier A., Bekel T., Bischoff N., Brune I., Chakraborty T., Kalinowski J., Meyer F., Rupp O., Schneiker S., Viehoever P., Puehler A.;
"Complete genome sequence and analysis of the multiresistant nosocomial pathogen Corynebacterium jeikeium K411, a lipid-requiring bacterium of the human skin flora.";
J. Bacteriol. 187:4671-4682(2005).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CR931997; CAI36948.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_250566.1; -.
3D structure databases
ModBase Q4JW59.
Enzyme and pathway databases
BioCyc CJEI306537:JK0786-MON; -.
Ontologies
GO
GO:0004399; Molecular function: histidinol dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0000105; Biological process: histidine biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_01024; -; 1.
PBIL [Tree]
InterPro IPR001692; Histidinol_DHase.
IPR012131; Hstdl_DHase_prok.
Graphical view of domain structure.
PANTHER PTHR21256:SF2; Hstdl_DH_prok; 1.
Pfam PF00815; Histidinol_dh; 1.
Pfam graphical view of domain structure.
PRINTS PR00083; HOLDHDRGNASE.
ProDom PD002680; Histidinol_dh; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR00069; hisD; 1.
PROSITE PS00611; HISOL_DEHYDROGENASE; 1.
BLOCKS Q4JW59.
Genome annotation databases
GeneID 3433179; -.
GenomeReviews CR931997_GR; jk0786.
KEGG cjk:jk0786; -.
NMPDR fig|306537.3.peg.1760; -.
Phylogenomic databases
HOGENOM Q4JW59; -.
Genome annotation databases
CMR Q4JW59; jk0786.
Other
ProtoNet Q4JW59.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Complete proteome; Histidine biosynthesis; Metal-binding; NAD; Oxidoreductase; Zinc.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   450  450     Histidinol dehydrogenase. PRO_0000135762
ACT_SITE   339   339        Proton acceptor (By similarity). 
ACT_SITE   340   340        Proton acceptor (By similarity). 
METAL   270   270        Zinc (By similarity). 
METAL   273   273        Zinc (By similarity). 
METAL   373   373        Zinc (By similarity). 
METAL   432   432        Zinc (By similarity). 
BINDING   135   135        NAD (By similarity). 
BINDING   197   197        NAD (By similarity). 
BINDING   225   225        NAD (By similarity). 
BINDING   248   248        Substrate (By similarity). 
BINDING   270   270        Substrate (By similarity). 
BINDING   273   273        Substrate (By similarity). 
BINDING   340   340        Substrate (By similarity). 
BINDING   373   373        Substrate (By similarity). 
BINDING   427   427        Substrate (By similarity). 
BINDING   432   432        Substrate (By similarity). 
Sequence information
Length: 450 AA [This is the length of the unprocessed precursor] Molecular weight: 46775 Da [This is the MW of the unprocessed precursor] CRC64: 2BED7B5FA2E531C5 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MTSAQLDFSR IDLRGQAPTT AELRHRLPRG GTDVDSVIPT VAPIVDQVRE GGARAALEIG 

        70         80         90        100        110        120 
QRFDGVTPDS VRVPAEVIDA AVGTLADDVI AALEEAIKRV RAFHSAIRPE DKQVEVAPGG 

       130        140        150        160        170        180 
IVTERFIPVQ RVGLYAPGGN AVYPSSVIMN VVPAQEAGVE SLVVASPPQE GGWPHPTVLA 

       190        200        210        220        230        240 
ACKLLGVDEV WAVGGAQAVA LLAHGSTAEG GEELEPVDMV TGPGNIFVTA AKRLCRSVVG 

       250        260        270        280        290        300 
IDSEAGPTEI AVLADESANA VEIAYDLISQ AEHDTMAASV LITDSEKLAD EVVAEMNERY 

       310        320        330        340        350        360 
HITENSERVA EALSGQQSGV VLVDDIAAGI RAANAYGAEH LEIHTEDAHG VAAQITNAGA 

       370        380        390        400        410        420 
IFIGRFSPVP LGDYAAGSNH VLPTSGTARH SSGLSTLTFL KSVHVIDYNE EGLRGVADTV 

       430        440        450 
ITLSKSEGLP AHGEAISART STANTNGTEV
Q4JW59 in FASTA format

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