NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1128/JB.187.21.7292-7308.2005; PubMed=16237012 [NCBI, ExPASy, EBI, Israel, Japan]
Takeuchi F., Watanabe S., Baba T., Yuzawa H., Ito T., Morimoto Y., Kuroda M., Cui L., Takahashi M., Ankai A., Baba S., Fukui S., Lee J.C., Hiramatsu K.;
"Whole-genome sequencing of Staphylococcus haemolyticus uncovers the extreme plasticity of its genome and the evolution of human-colonizing staphylococcal species.";
J. Bacteriol. 187:7292-7308(2005).

Comments

CATALYTIC ACTIVITY: L-proline + NAD(P)⁺ = 1-pyrroline-5-carboxylate + NAD(P)H.
PATHWAY: Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1 .
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
SIMILARITY: Belongs to the pyrroline-5-carboxylate reductase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AP006716; BAE04722.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

YP_253328.1; -.

3D structure databases

ModBase

Q4L6K3.

Enzyme and pathway databases

BioCyc

SHAE279808:SH1413-MON; -.

Family and domain databases

InterPro

IPR004455; NADP_OxRdtase_F420.
IPR000304; P5CR.
Graphical view of domain structure.

PANTHER

PTHR11645; P5CR; 1.

Pfam

PF03807; F420_oxidored; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF000193; Pyrrol-5-carb_rd; 1.

TIGRFAMs

TIGR00112; proC; 1.

BLOCKS

Q4L6K3.

Genome annotation databases

3483380; -.

AP006716_GR; SH1413.

sha:SH1413; -.

fig|279808.3.peg.1901; -.

Phylogenomic databases

HOGENOM

Q4L6K3; -.

Genome annotation databases

CMR

Q4L6K3; SH1413.

Other

ProtoNet

Q4L6K3.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Amino-acid biosynthesis; Complete proteome; Cytoplasm; NADP; Oxidoreductase; Proline biosynthesis.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 271`	`271`		`Pyrroline-5-carboxylate reductase.`	`PRO_0000187306`

Sequence information

Length: 271 AA [This is the length of the unprocessed precursor]

Molecular weight: 30168 Da [This is the MW of the unprocessed precursor]

CRC64: 90DAC8041979B794 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MKLVFYGAGN MAQAIFKGII NSKKLKSHDI YLTNKSNEEA LKNFAEELGV EYSYDDEKLL 

        70         80         90        100        110        120 
QDADYVFLGS KPYDFEKVAQ RIQPYINENN RFISIMAGLP INYIQEQLQV ENPIARIMPN 

       130        140        150        160        170        180 
TNAQVGHSVT GISFSGNFGP KSKEEVNDLV NAFGSVIEVD EDHLHQVTAI TGSGPAFLYH 

       190        200        210        220        230        240 
VFEQYVKAGT DLGLEKDQVE ESIKNLIIGT SKMIERSDLS MEQLRKNITS KGGTTQAGLN 

       250        260        270 
ALAQHDIEAI FKDCLNAAVH RSVELSKNED N

Q4L6K3 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools