[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. TISSUE=Testis; International consortium for macaque cDNA sequencing and analysis; "DNA sequences of macaque genes expressed in brain or testis and its evolutionary implications."; Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.

Comments

CATALYTIC ACTIVITY: L-iditol + NAD⁺ = L-sorbose + NADH.
COFACTOR: Binds 1 zinc ion per subunit (By similarity).
SUBUNIT: Homotetramer (By similarity).
SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase family.

Copyright

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Cross-references

Sequence databases

EMBL

AB169351; BAE01436.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

SMR

Q4R639; 1-356, 2-357.

ModBase

Q4R639.

Family and domain databases

InterPro

IPR013154; AlcDHase_GroES-like.
IPR002085; AlcDHase_SF_Zn.
IPR013149; AlcDHase_Zn-bd.
IPR002328; AlcDHase_Zn_CS.
Graphical view of domain structure.

PANTHER

PTHR11695; ADH_Sf_Zn; 1.

Pfam

PF08240; ADH_N; 1.
PF00107; ADH_zinc_N; 1.
Pfam graphical view of domain structure.

PROSITE

PS00059; ADH_ZINC; 1.

BLOCKS

Q4R639.

Phylogenomic databases

HOVERGEN

Q4R639; -.

Other

ProtoNet

Q4R639.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Acetylation; Metal-binding; NAD; Oxidoreductase; Zinc.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`INIT_MET`	`1 1`		`Removed (By similarity).`
`CHAIN`	`2 357`	`356`	`Sorbitol dehydrogenase.`	`PRO_0000231004`
`METAL`	`45 45`		`Zinc; catalytic (By similarity).`
`METAL`	`70 70`		`Zinc; catalytic (By similarity).`
`METAL`	`71 71`		`Zinc; catalytic (By similarity).`
`MOD_RES`	`2 2`		`N-acetylalanine (By similarity).`

Sequence information

Length: 357 AA [This is the length of the unprocessed precursor]

Molecular weight: 38206 Da [This is the MW of the unprocessed precursor]

CRC64: 4BB2278B107274CD [This is a checksum on the sequence]

        10         20         30         40         50         60 
MAAAAKPKNL SLVVHGPGDL RLENYPIPEP GPNEVLLRMH SVGICGSDVH YWEEGRIGNF 

        70         80         90        100        110        120 
IVKKPMVLGH EASGTVEKVG SLVKHLKPGD RVAIEPGVPR ENDEFCKSGR YNLSPSIFFC 

       130        140        150        160        170        180 
ATPPDDGNLC RFYKHNAAFC YKLPDNVTFE EGALIEPLSV GIHACRRGGV TLGHRVLVCG 

       190        200        210        220        230        240 
AGPIGVVSLL VAKAMGAAQV VVTDLSAPRL SKAKEIGADL VLQISKESPQ EIAGKVEGLL 

       250        260        270        280        290        300 
GCKPEVTIEC TGAEASIQAG IYATRSGGTL VLVGLGSEMT TIPLLHAAVR EVDIKGVFRY 

       310        320        330        340        350 
CNTWPVAISM LASKSVNIKP LVTHRFPLEK ALEAFETFKK GLGLKIMLKC DPNDQNP

Q4R639 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools