[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. TISSUE=Testis; International consortium for macaque cDNA sequencing and analysis; "DNA sequences of macaque genes expressed in brain or testis and its evolutionary implications."; Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.

Comments

CATALYTIC ACTIVITY: sn-glycerol 3-phosphate + acceptor = glycerone phosphate + reduced acceptor.
COFACTOR: FAD (By similarity).
ENZYME REGULATION: Calcium-binding enhance the activity of the enzyme (By similarity).
PATHWAY: Polyol metabolism; glycerol degradation via glycerol kinase pathway; glycerone phosphate from sn-glycerol 3-phosphate (aerobic route): step 1/1 .
SUBCELLULAR LOCATION: Mitochondrion (By similarity).
SIMILARITY: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.
SIMILARITY: Contains 2 EF-hand domains.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AB168970; BAE01068.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

ModBase

Q4R755.

Ontologies

GO:0009331;	Cellular component: glycerol-3-phosphate dehydrogenase complex (inferred from electronic annotation from InterPro).
GO:0005739;	Cellular component: mitochondrion (inferred from electronic annotation from UniProtKB-KW).
GO:0005509;	Molecular function: calcium ion binding (inferred from electronic annotation from InterPro).
GO:0004368;	Molecular function: glycerol-3-phosphate dehydrogenase activity (inferred from electronic annotation from InterPro).
GO:0006072;	Biological process: glycerol-3-phosphate metabolic process (inferred from electronic annotation from InterPro).
GO:0055114;	Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR011992; EF-Hand_type.
IPR002048; EF_hand_Ca_bd.
IPR000447; FAD-dep_Gly3P_DHase.
IPR006076; FAD-dep_OxRdtase.
Graphical view of domain structure.

Gene3D

G3DSA:1.10.238.10; EF-Hand_type; 1.

Pfam

PF01266; DAO; 1.
PF00036; efhand; 2.
Pfam graphical view of domain structure.

PRINTS

PR01001; FADG3PDH.

ProDom

PD000012; EF-hand; 1.
[Domain structure / List of seq. sharing at least 1 domain]

SMART

SM00054; EFh; 2.
SMART graphical view of domain structure.

PROSITE

PS00018; EF_HAND_1; 1.
PS50222; EF_HAND_2; 2.
PS00977; FAD_G3PDH_1; 1.
PS00978; FAD_G3PDH_2; 1.
PROSITE graphical view of domain structure (profiles).

Phylogenomic databases

HOVERGEN

Q4R755; -.

Other

ProtoNet

Q4R755.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Calcium; FAD; Flavoprotein; Mitochondrion; Oxidoreductase; Phosphoprotein; Repeat; Transit peptide.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`TRANSIT`	`1 42`	`42`	`Mitochondrion (By similarity).`
`CHAIN`	`43 727`	`685`	`Glycerol-3-phosphate dehydrogenase, mitochondrial.`	`PRO_0000270069`
`DOMAIN`	`623 658`	`36`	`EF-hand 1.`
`DOMAIN`	`659 694`	`36`	`EF-hand 2.`
`NP_BIND`	`71 99`	`29`	`FAD (Potential).`
`CA_BIND`	`672 683`	`12`	`Potential.`
`MOD_RES`	`600 600`		`Phosphotyrosine (By similarity).`
`MOD_RES`	`601 601`		`Phosphotyrosine (By similarity).`

Sequence information

Length: 727 AA [This is the length of the unprocessed precursor]

Molecular weight: 80801 Da [This is the MW of the unprocessed precursor]

CRC64: CFB9E66271721B66 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MAFQKAVKGT ILVGGGALAT VLGLSQFAHY RRKQMNLAYV KAADYISEPV NREPPSREAQ 

        70         80         90        100        110        120 
LLTLQNTSEF DILVIGGGAT GSGCALDAVT RGLKTALVER DDFSSGTSSR STKLIHGGVR 

       130        140        150        160        170        180 
YLQKAIMKLD IEQYRMVKEA LHERANLLEI APHLSAPLPI VLPVYKWWQL PYYWVGIKLY 

       190        200        210        220        230        240 
DLVAGSNCLK SSYVLSKSRA LEHFPMLQKD KLVGAIVYYD GQHNDARMNL AIALTAARYG 

       250        260        270        280        290        300 
AATANYMEVV SLLKKTDPQT GKVRVSGARC KDVLTGQEFD VRAKCVINAT GPFTDSVRKM 

       310        320        330        340        350        360 
DDKDAAAICQ PSAGVHIVMP GYYSPESMGL LDPATSDGRV IFFLPWQKMT IAGTTDTPTD 

       370        380        390        400        410        420 
VTPHPIPSEE DINFILNEVR NYLSCDVEVR RGDVLAAWSG IRPLVTDPKS ADTQSISRNH 

       430        440        450        460        470        480 
VVDISESGLI TIAGGKWTTY RSMAEDTINA AIKTHNLKAG PSRTVGLFLQ GGKDWSPTLY 

       490        500        510        520        530        540 
IRLVQDYGLE SEVAQHLAAT YGDKAFEVAK MASVTGKRWP IVGVRLVSEF PYIEAEVKYG 

       550        560        570        580        590        600 
IKEYACTAVD MISRRTRLAF LNVQAAEEAL PRIVELMGRE LNWDDHKKQE QLETAKKFLY 

       610        620        630        640        650        660 
YEMGYKSRSE QLTDRSEISL LPSDIDRYKK RFHKFDADKK GFITIVDVQR VLESINVQMD 

       670        680        690        700        710        720 
ENTLHEILNE VDLNKNGQVE LNEFLQLMSA IQKGRVSGSR LAILMKTAEE NLDRRVPIPV 


DRSCGGL

Q4R755 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools