NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC VR-1525 / URRWXCal2;
DOI=10.1371/journal.pbio.0030248; PubMed=15984913 [NCBI, ExPASy, EBI, Israel, Japan]
Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E., Parinello H., Claverie J.-M., Raoult D.;
"The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite.";
PLoS Biol. 3:1-12(2005).

Comments

FUNCTION: The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).
CATALYTIC ACTIVITY: 2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO₂.
COFACTOR: Thiamine pyrophosphate (By similarity).
SUBUNIT: Homodimer (By similarity).
SIMILARITY: Belongs to the alpha-ketoglutarate dehydrogenase family.
SIMILARITY: Contains 1 RPE1 insert domain.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

CP000053; AAY61943.1; ALT_INIT; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

YP_247108.1; -.

3D structure databases

ModBase

Q4UKI8.

Enzyme and pathway databases

BioCyc

RFEL315456:RF_1092-MON; -.

Family and domain databases

InterPro

IPR011603; 2oxoglutarate_DHase_E1.
IPR001017; DHase_E1.
IPR005728; Rickett_RPE.
IPR005475; Transketo_Cen_R.
Graphical view of domain structure.

PANTHER

PTHR23152; 2oxoglutarate_DH_E1; 1.

Pfam

PF00676; E1_dh; 1.
PF02779; Transket_pyr; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF000157; Oxoglu_dh_E1; 1.

TIGRFAMs

TIGR00239; 2oxo_dh_E1; 1.
TIGR01045; RPE; 1.

BLOCKS

Q4UKI8.

Genome annotation databases

GeneID

3400202; -.

GenomeReviews

CP000053_GR; RF_1092.

KEGG

rfe:RF_1092; -.

NMPDR

fig|315456.3.peg.1091; -.

Phylogenomic databases

HOGENOM

Q4UKI8; -.

Genome annotation databases

CMR

Q4UKI8; RF_1092.

Other

ProtoNet

Q4UKI8.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; Glycolysis; Oxidoreductase; Thiamine pyrophosphate.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 977`	`977`	`2-oxoglutarate dehydrogenase E1 component.`	`PRO_0000288750`
`DOMAIN`	`77 125`	`49`	`RPE1 insert.`

Sequence information

Length: 977 AA [This is the length of the unprocessed precursor]

Molecular weight: 109496 Da [This is the MW of the unprocessed precursor]

CRC64: B0B3FAD38BA0533F [This is a checksum on the sequence]

        10         20         30         40         50         60 
MEEDLKKTGY LFGGNAVFVD ELYRQYLANP ASVDQTWQEF FAGIKDNSTV LNKSTAKIII 

        70         80         90        100        110        120 
PYEIKKEPLN NNLSSEVLNN RHLAKPAYRE EFKGDTERST AAYIDIREDA STGSTSKLPL 

       130        140        150        160        170        180 
EAKFGKMSSL KAKEMINTYR KHAHYLANLD PLGLELRKTK NDLKLNIETF GLDNSQLEKN 

       190        200        210        220        230        240 
INITDEFVGN WNCKLSELVT KLDKTYTGSI GVEFEQIENV EEKNWLYNKL ESEVTFSSED 

       250        260        270        280        290        300 
KKTILNDLVE VEGFEQYLHT KFPGAKRFSV EGGDASIVAM SKAIDLSMNQ GVEEIVIGMA 

       310        320        330        340        350        360 
HRGRLNTLTK VVGKPYKAVI AGFISGSVFP DELNVSGDVK YHLGYSSDRT IDNKKIHLSL 

       370        380        390        400        410        420 
ADNPSHLEAV NPIVAGKVRA KQDILGDTKR SKVKAILVHG DAAFCGQGVV AESLSMSPLA 

       430        440        450        460        470        480 
AYDIGGILHF VINNQLGFTA NAADTRASRY STEFAKIIAA PILHVNGDDI EAVLKATNIA 

       490        500        510        520        530        540 
VEYRQKFGKD VVVEIICYRK YGHNEGDEPM YTQGKMYNII KSKPTPGNIY ANELVKSGII 

       550        560        570        580        590        600 
DNNYFAKLKE EFKAKLDKEF EQAKNYKPEA HFLGGLWQGI SRIRTQAAIT GVGKKTLQDL 

       610        620        630        640        650        660 
GTKLCEIPKD FAVNPKLVKL FEARKATLTS DQPIDWATAE QLAFASLLSE GTNIRLTGQD 

       670        680        690        700        710        720 
CGRGTFSHRH SVLHNQIDDT TYIPLNNLSK TQAKYEVADS NLSEYAVLGF EYGYSLANPK 

       730        740        750        760        770        780 
NLVLWEAQFG DFANGAQIIF DQFISSSETK WLRMSGLVVL LPHAFEGQGP EHSSARLERF 

       790        800        810        820        830        840 
LQLAAEDNMY VTYPTTPASI FHLLRRQILD DTRKPLIIMS PKSLLRHKYA VSKLDELGEN 

       850        860        870        880        890        900 
TTFLPVLDEV NKVDTNNITK VILCSGKVYY DLFEMRGNNS NIAIIRLEQL YPFEKKLVAS 

       910        920        930        940        950        960 
LLKKYNRTQE FIWCQEEPKN MGAWRYIVSH LNDVLKEAGI NNEFKYVGRE ESASPAVGSL 

       970 
QAHNKQQEKL LKEALGM

Q4UKI8 in FASTA format

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View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools