NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C., Fraser C.M.;
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.

[2]

NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-55.
PubMed=8655566 [NCBI, ExPASy, EBI, Israel, Japan]
Dhandayuthapani S., Zhang Y., Mudd M.H., Deretic V.;
"Oxidative stress response and its role in sensitivity to isoniazid in mycobacteria: characterization and inducibility of ahpC by peroxides in Mycobacterium smegmatis and lack of expression in M. aurum and M. tuberculosis.";
J. Bacteriol. 178:3641-3649(1996).

Comments

FUNCTION: Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the ahpC active site cysteine residues and for the regeneration of the ahpC enzyme activity (By similarity).
CATALYTIC ACTIVITY: 2 R'-SH + ROOH = R'-S-S-R' + H₂O + ROH.
SUBUNIT: Homotrimer. Identified in a complex with ahpC and lpd (By similarity).
SIMILARITY: Belongs to the ahpD family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

CP000480; ABK74352.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
U43719; AAC44140.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

YP_889146.1; -.

3D structure databases

ModBase

Q50441.

Ontologies

GO:0051920;	Molecular function: peroxiredoxin activity (inferred from electronic annotation from EC).
GO:0055114;	Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR004674; AhpD.
IPR004675; AhpD_core.
IPR003779; CMD.
Graphical view of domain structure.

Pfam

PF02627; CMD; 1.
Pfam graphical view of domain structure.

TIGRFAMs

TIGR00777; ahpD; 1.
TIGR00778; ahpD_dom; 1.

Genome annotation databases

GeneID

4535695; -.

GenomeReviews

CP000480_GR; MSMEG_4890.

KEGG

msm:MSMEG_4890; -.

TIGR

MSMEG_4890; -.

Other

ProtoNet

Q50441.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Antioxidant; Complete proteome; Oxidoreductase; Peroxidase; Redox-active center.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 177`	`177`	`Alkyl hydroperoxide reductase ahpD.`	`PRO_0000064506`
`ACT_SITE`	`130 130`		`Proton donor (By similarity).`
`ACT_SITE`	`133 133`		`Cysteine sulfenic acid (-SOH) intermediate (By similarity).`
`DISULFID`	`130 133`		`Alternate (By similarity).`
`DISULFID`	`133 133`		`Interchain (with C-61 in ahpC); in linked form (By similarity).`
`CONFLICT`	`28 30`		`Missing (in Ref. 2; AAC44140).`

Sequence information

Length: 177 AA [This is the length of the unprocessed precursor]

Molecular weight: 18837 Da [This is the MW of the unprocessed precursor]

CRC64: BFDA644673FA4932 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSIDNIKSAL PEYAKDLKLN LGSIANTTEL TEQQLWGALV ATAAATKNAR LLREISEDAL 

        70         80         90        100        110        120 
DILSEEAYNA ALGAAAIMGM NNVFYRTKGQ LDGKYDDLRA GLRMNIIGNP GVAKEDFELW 

       130        140        150        160        170 
SLAVSAINGC GHCLAAHEKT LRDADVARTT IFEAIRLASI VSGVAQALLT ADTLAAV

Q50441 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools