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UniProtKB/Swiss-Prot entry Q51801


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name VORA_PYRFU
Primary accession number Q51801
Secondary accession numbers None
Integrated into Swiss-Prot on May 30, 2000
Sequence was last modified on November 1, 1996 (Sequence version 1)
Annotations were last modified on    September 2, 2008 (Entry version 52)
Name and origin of the protein
Protein name Ketoisovalerate oxidoreductase subunit vorA
Synonyms VOR
EC 1.2.7.7
2-oxoisovalerate oxidoreductase alpha chain
2-oxoisovalerate ferredoxin reductase subunit alpha
Gene name
Name: vorA
OrderedLocusNames: PF0969
From
Pyrococcus furiosus [TaxID: 2261] [HAMAP proteome]
Taxonomy Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae; Pyrococcus.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 1-22.
STRAIN=ATCC 43587 / DSM 3638 / JCM 8422 / Vc1;
PubMed=8550425 [NCBI, ExPASy, EBI, Israel, Japan]
Kletzin A., Adams M.W.W.;
"Molecular and phylogenetic characterization of pyruvate and 2-ketoisovalerate ferredoxin oxidoreductases from Pyrococcus furiosus and pyruvate ferredoxin oxidoreductase from Thermotoga maritima.";
J. Bacteriol. 178:248-257(1996).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 43587 / DSM 3638 / JCM 8422 / Vc1;
Weiss R.B., Dunn D.M., Robb F.T., Brown J.R.;
"The complete sequence of the Pyrococcus furiosus genome.";
Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases.
Comments
  • CATALYTIC ACTIVITY: 3-methyl-2-oxobutanoate + CoA + 2 oxidized ferredoxin = S-(2-methylpropanoyl)-CoA + CO2 + 2 reduced ferredoxin + H+.
  • SUBUNIT: Heterotetramer of one alpha, one beta, one delta and one gamma chain.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X85250; CAA59502.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AE010209; AAL81093.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR T45085; T45085.
RefSeq NP_578698.1; -.
3D structure databases
HSSP P94692; 1KEK. [HSSP ENTRY / PDB]
ModBase Q51801.
Family and domain databases
InterPro IPR002880; Pyrv_Fd/Flavodoxin_OxRdtase_N.
IPR015941; Transketolase_C-like.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.920; Transketo_C_like; 1.
Pfam PF01855; POR_N; 1.
Pfam graphical view of domain structure.
BLOCKS Q51801.
Genome annotation databases
GeneID 1468834; -.
GenomeReviews AE009950_GR; PF0969.
KEGG pfu:PF0969; -.
NMPDR fig|186497.1.peg.1005; -.
Phylogenomic databases
HOGENOM Q51801; -.
Genome annotation databases
CMR Q51801; PF0969.
Other
ProtoNet Q51801.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Direct protein sequencing; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom To Length Description FTId
CHAIN   1   394  394     Ketoisovalerate oxidoreductase subunit vorA. PRO_0000099952
Sequence information
Length: 394 AA [This is the length of the unprocessed precursor] Molecular weight: 43960 Da [This is the MW of the unprocessed precursor] CRC64: D8E580E790CEBB2B [This is a checksum on the sequence]
        10         20         30         40         50         60 
MEYKPIRKVV SGNYAAAYAA LHARVQVVAA YPITPQTSII EKIAEFIANG EADIQYIPVE 

        70         80         90        100        110        120 
SEHSAMAACI GASATGARTF TATSAQGLAL MHEMLHWAAG ARLPIVMVDV NRAMAPPWSV 

       130        140        150        160        170        180 
WDDQTDSLSQ RDTGWMQFYA ENNQEVYDGV LMAYKVAETV NVPAMVVESA FILSHTYDVV 

       190        200        210        220        230        240 
EMIPQELVDE FLPPRKPLYS LANFDEPIAV GALATPNDYY EFRYKLAKAH EEAKKVIKEV 

       250        260        270        280        290        300 
GKEFGERFGR DYSQMIETGY IDDADFVFMG MGSLMGTVKE AVDLLRKEGY KVGYAKVRWF 

       310        320        330        340        350        360 
RPFPKEELVE IAESVKGIAV LDRNFSFGQE GILFTESKGA LYNSSAHPLM KNYIVGLGGR 

       370        380        390 
DVTVKDIKAI ADDMKKVIES GKVDKEVVWY HLKR 

Q51801 in FASTA format

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