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UniProtKB/Swiss-Prot entry Q54E41


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HAOX_DICDI
Primary accession number Q54E41
Secondary accession numbers None
Integrated into Swiss-Prot on April 8, 2008
Sequence was last modified on May 24, 2005 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 30)
Name and origin of the protein
Protein name Hydroxyacid oxidase
Synonyms HAOX
EC 1.1.3.15
Glycolate oxidase
GOX
Gene name
Name: haox
ORFNames: DDB_0184082
From
Dictyostelium discoideum (Slime mold) [TaxID: 44689] 
Taxonomy Eukaryota; Mycetozoa; Dictyosteliida; Dictyostelium.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=AX4;
DOI=10.1038/nature03481; PubMed=15875012 [NCBI, ExPASy, EBI, Israel, Japan]
Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
"The genome of the social amoeba Dictyostelium discoideum.";
Nature 435:43-57(2005).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AAFI02000185; EAL61528.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq XP_629946.1; -.
3D structure databases
ModBase Q54E41.
Organism-specific databases
dictyBase DDB0184082; haox.
Ontologies
GO
GO:0003973; Molecular function: (S)-2-hydroxy-acid oxidase activity (inferred from electronic annotation from EC).
QuickGo view.
Family and domain databases
InterPro IPR013785; Aldolase_TIM.
IPR012133; Alpha_OHA_DHase_FMN.
IPR008259; FMN_hydac_DHase_AS.
IPR000262; FMN_OHA_DHase.
Graphical view of domain structure.
Gene3D G3DSA:3.20.20.70; Aldolase_TIM; 1.
Pfam PF01070; FMN_dh; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000138; Al-hdrx_acd_dh; 1.
PROSITE PS00557; FMN_HYDROXY_ACID_DH_1; 1.
PS51349; FMN_HYDROXY_ACID_DH_2; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q54E41.
Genome annotation databases
GeneID 3386608; -.
KEGG ddi:DDBDRAFT_0184082; -.
Other
ProtoNet Q54E41.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Flavoprotein; FMN; Glycolate pathway; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   388  388     Hydroxyacid oxidase. PRO_0000328260
DOMAIN   26   384  359     FMN hydroxy acid dehydrogenase. 
NP_BIND   310   334  25     FMN (By similarity). 
COMPBIAS   7    10  4     Poly-Asn. 
ACT_SITE   279   279        Proton acceptor (By similarity). 
BINDING   52    52        Substrate (Potential). 
BINDING   134   134        FMN (By similarity). 
BINDING   156   156        FMN (By similarity). 
BINDING   158   158        Substrate (By similarity). 
BINDING   184   184        FMN (By similarity). 
BINDING   193   193        Substrate (By similarity). 
BINDING   255   255        FMN (By similarity). 
BINDING   282   282        Substrate (Potential). 
Sequence information
Length: 388 AA [This is the length of the unprocessed precursor] Molecular weight: 42877 Da [This is the MW of the unprocessed precursor] CRC64: C42C59FFE992395D [This is a checksum on the sequence]
        10         20         30         40         50         60 
MENQFKNNNN SSSIETSNQF SNKKTNRLDS FVSVSELHEE AKRLLPKMAY DYYASGSNDQ 

        70         80         90        100        110        120 
ITLAENENAF SRIKLVPRSL VDVSKVNTKT RIFGRDISTP ILIAPWAMQR MASQRGELDT 

       130        140        150        160        170        180 
VEASKEFNTI MTLSSLSTTS VEDLSSATNG NPGWFQLYVF KDRKVSEELV KRAESIGYSA 

       190        200        210        220        230        240 
LVLTVDTPFL GKRTADFKNS FKLPNGLSLK IFEKLMLSNL DGGLNQYIAT MIDPSLTWND 

       250        260        270        280        290        300 
LKWLKSITKL PILVKGIMCP KDAELALQYG ADGIIVSNHG GRQLDTCPST IEVLPYISKV 

       310        320        330        340        350        360 
VRGRVPLILD GGIRRGTDVL KALAFGANAV CIGRPIIWGL STGGKDGVLK VLNLLNSELQ 

       370        380 
LAMALTGITN ISDINNSIIW DQNKYIKL 

Q54E41 in FASTA format

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