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UniProtKB/Swiss-Prot entry Q54XS1


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name PH4H_DICDI
Primary accession number Q54XS1
Secondary accession numbers None
Integrated into Swiss-Prot on April 8, 2008
Sequence was last modified on May 24, 2005 (Sequence version 1)
Annotations were last modified on    September 2, 2008 (Entry version 26)
Name and origin of the protein
Protein name Probable phenylalanine-4-hydroxylase
Synonyms PAH
EC 1.14.16.1
Phe-4-monooxygenase
Gene name
Name: pah
ORFNames: DDB_0231664
From
Dictyostelium discoideum (Slime mold) [TaxID: 44689] 
Taxonomy Eukaryota; Mycetozoa; Dictyosteliida; Dictyostelium.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=AX4;
DOI=10.1038/nature03481; PubMed=15875012 [NCBI, ExPASy, EBI, Israel, Japan]
Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
"The genome of the social amoeba Dictyostelium discoideum.";
Nature 435:43-57(2005).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AAFI02000024; EAL67992.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq XP_641959.1; -.
3D structure databases
ModBase Q54XS1.
Organism-specific databases
dictyBase DDB0231664; pah.
Family and domain databases
InterPro IPR001273; Aaa_hydroxylase.
IPR002912; ACT_bd.
IPR001086; Preph_deHydtase.
Graphical view of domain structure.
Gene3D G3DSA:1.10.800.10; Aaa_hydroxylase; 1.
PANTHER PTHR11473; Aaa_hydroxylase; 1.
Pfam PF01842; ACT; 1.
PF00351; Biopterin_H; 1.
Pfam graphical view of domain structure.
PRINTS PR00372; FYWHYDRXLASE.
ProDom PD002559; Aaa_hydroxylase; 1.
[Domain structure / List of seq. sharing at least 1 domain]
PROSITE PS00367; BIOPTERIN_HYDROXYL; 1.
BLOCKS Q54XS1.
Genome annotation databases
GeneID 3393142; -.
KEGG ddi:DDB_0231664; -.
Other
ProtoNet Q54XS1.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Iron; Metal-binding; Monooxygenase; Oxidoreductase; Phenylalanine catabolism.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   441  441     Probable phenylalanine-4-hydroxylase. PRO_0000328336
DOMAIN   23    89  67     ACT. 
METAL   273   273        Iron (By similarity). 
METAL   278   278        Iron (By similarity). 
METAL   318   318        Iron (By similarity). 
Sequence information
Length: 441 AA [This is the length of the unprocessed precursor] Molecular weight: 50415 Da [This is the MW of the unprocessed precursor] CRC64: D02E03F28A873D1C [This is a checksum on the sequence]
        10         20         30         40         50         60 
MESNTNSQGQ GIIPQSYHSS IFFSISKGSD KIGGLLEYLE IIKKHNINIT RIESRPSKTE 

        70         80         90        100        110        120 
KKDYDFFLDL EYPTENNKEV EKVIKDLEEK GVKATTLQES SNQTYAPWFP RKISDLDLFA 

       130        140        150        160        170        180 
NKVLEMGSDL TSDHPGASDP VYRERRREIA KIASTYKHGD EIPRIDYTEE EIKTWGVVYN 

       190        200        210        220        230        240 
RLKELFPTNA CHQHAYIFPL LEQNCGYSPD NIPQLQDISN FLQECTGWRI RPVQGLLSAR 

       250        260        270        280        290        300 
DFLNGLAFRV FHATQYIRHP SVPLYTPEPD CCHELLGHVP LLADPDFADF SQEIGLASIG 

       310        320        330        340        350        360 
ASDEDIQLLS TCYWFTVEFG LCKEGDTIRA YGAGILSSTG EMEHFLTDKA KKLPFNPFDA 

       370        380        390        400        410        420 
CNTEYPITTF QPLYYVAESF QKAKEQMRQF ADSFKKPFSI RYNPYTQSIE ILDNKDKLLN 

       430        440 
ICNDIRNQSE ILADAISKLK A 

Q54XS1 in FASTA format

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BLAST logo BLAST submission on ExPASy/SIB
or at NCBI (USA)
Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

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