NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=9-941 / Biovar 1;
DOI=10.1128/JB.187.8.2715-2726.2005; PubMed=15805518 [NCBI, ExPASy, EBI, Israel, Japan]
Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.;
"Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis.";
J. Bacteriol. 187:2715-2726(2005).

Comments

CATALYTIC ACTIVITY: 2,3,4,5-tetrahydrodipicolinate + NAD(P)⁺ = 2,3-dihydrodipicolinate + NAD(P)H.
PATHWAY: Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; tetrahydrodipicolinate from L-aspartate: step 4/4 .
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
SIMILARITY: Belongs to the dihydrodipicolinate reductase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AE017224; AAX76370.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

YP_223731.1; -.

3D structure databases

ModBase

Q576R4.

Enzyme and pathway databases

BioCyc

BABO262698:BRUAB2_0991-MON; -.

Ontologies

GO:0005737;	Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0008839;	Molecular function: dihydrodipicolinate reductase activity (inferred from electronic annotation from HAMAP).
GO:0019877;	Biological process: diaminopimelate biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_00102; -; 1.
PBIL [Tree]

InterPro

IPR000846; DapB.
IPR011770; DapB_bac/pln.
Graphical view of domain structure.

PANTHER

PTHR20836; DapB_bac/pln; 1.

Pfam

PF05173; DapB_C; 1.
PF01113; DapB_N; 1.
Pfam graphical view of domain structure.

ProDom

PD004105; DapB; 1.
[Domain structure / List of seq. sharing at least 1 domain]

TIGR00036; dapB; 1.

PS01298; DAPB; 1.

Genome annotation databases

GeneID

3341712; -.

GenomeReviews

AE017224_GR; BruAb2_0991.

KEGG

bmb:BruAb2_0991; -.

Phylogenomic databases

HOGENOM

Q576R4; -.

Genome annotation databases

CMR

Q576R4; BruAb2_0991.

Other

ProtoNet

Q576R4.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Amino-acid biosynthesis; Complete proteome; Cytoplasm; Diaminopimelate biosynthesis; Lysine biosynthesis; NADP; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 268`	`268`		`Dihydrodipicolinate reductase.`	`PRO_0000228330`

Sequence information

Length: 268 AA [This is the length of the unprocessed precursor]

Molecular weight: 27605 Da [This is the MW of the unprocessed precursor]

CRC64: 1D48EC7280B56A17 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MGLVVVGAGG RMGQTLIRTI QSIEGAKLVG AIERSGSPFL GKDAGEVTGI GTLGVAITDD 

        70         80         90        100        110        120 
PLPVFAKAHG VLDFTSPAAS VEFAGLAAQA RIVHVIGTTG CSAEDDEKIR AAARHATIVK 

       130        140        150        160        170        180 
SGNMSLGVNL LSVLVQKAAE ALGPEDFDIE ILEMHHRHKV DAPSGTALLL GEAAARGRDI 

       190        200        210        220        230        240 
ALADNSVRVR DGYTGPRETG AIGFATLRGG SVIGDHSVIL AGTGERVVLS HHAEDRSIFA 

       250        260 
RGAIKAALWA HGKKPGLYSM LDVLGLNT

Q576R4 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools