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UniProtKB/Swiss-Prot entry Q5JHB5

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name G3P_PYRKO
Primary accession number Q5JHB5
Secondary accession numbers None
Integrated into Swiss-Prot on August 30, 2005
Sequence was last modified on February 15, 2005 (Sequence version 1)
Annotations were last modified on    September 2, 2008 (Entry version 30)
Name and origin of the protein
Protein name Glyceraldehyde-3-phosphate dehydrogenase
Synonyms GAPDH
EC 1.2.1.59
NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase
Gene name
Name: gap
OrderedLocusNames: TK0765
From
Pyrococcus kodakaraensis (Thermococcus kodakaraensis) [TaxID: 69014] [HAMAP proteome]
Taxonomy Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae; Thermococcus.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=KOD1;
DOI=10.1101/gr.3003105; PubMed=15710748 [NCBI, ExPASy, EBI, Israel, Japan]
Fukui T., Atomi H., Kanai T., Matsumi R., Fujiwara S., Imanaka T.;
"Complete genome sequence of the hyperthermophilic archaeon Thermococcus kodakaraensis KOD1 and comparison with Pyrococcus genomes.";
Genome Res. 15:352-363(2005).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AP006878; BAD84954.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_183178.1; -.
3D structure databases
SMR Q5JHB5; 1-334.
ModBase Q5JHB5.
Enzyme and pathway databases
BioCyc TKOD69014:TK0765-MON; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0004365; Molecular function: glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity (inferred from electronic annotation from HAMAP).
GO:0006096; Biological process: glycolysis (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00559; -; 1.
PBIL [Tree]
InterPro IPR000173; GlycerAld_3-P_DHase.
IPR006436; Glyceraldehyde-3-P_DHase_2_arc.
Graphical view of domain structure.
PANTHER PTHR10836; GAP_DH; 1.
Pfam PF02800; Gp_dh_C; 1.
PF00044; Gp_dh_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000149; GAP_DH; 1.
ProDom PD007761; GAPDH_like; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR01546; GAPDH-II_archae; 1.
PROSITE PS00071; GAPDH; 1.
BLOCKS Q5JHB5.
Genome annotation databases
GeneID 3234767; -.
GenomeReviews AP006878_GR; TK0765.
KEGG tko:TK0765; -.
NMPDR fig|69014.3.peg.1068; -.
Phylogenomic databases
HOGENOM Q5JHB5; -.
Genome annotation databases
CMR Q5JHB5; TK0765.
Other
ProtoNet Q5JHB5.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Cytoplasm; Glycolysis; NAD; NADP; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   334  334     Glyceraldehyde-3-phosphate dehydrogenase. PRO_0000145732
NP_BIND   12    13  2     NAD (By similarity). 
REGION   140   142  3     Glyceraldehyde 3-phosphate binding (By similarity). 
REGION   192   193  2     Glyceraldehyde 3-phosphate binding (By similarity). 
ACT_SITE   141   141        Nucleophile (By similarity). 
BINDING   111   111        NAD; via amide nitrogen (By similarity). 
BINDING   167   167        NAD (By similarity). 
BINDING   298   298        NAD; via carbonyl oxygen (By similarity). 
Sequence information
Length: 334 AA [This is the length of the unprocessed precursor] Molecular weight: 37236 Da [This is the MW of the unprocessed precursor] CRC64: 2FB063D9692F7E90 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MKVKVGINGY GTIGKRVAYA VSKQDDMELI GVTKTKPDFE AYLARERGIP VYAASEEFLP 

        70         80         90        100        110        120 
RFEKAGFEVA GTLSDLLENV DVIVDATPGG MGAKNKALYE KAGVKAIFQG GEKAEVAQVS 

       130        140        150        160        170        180 
FVAQANYEKA LGKDYVRVVS CNTTGLTRTL SALQEYIDYV YAVMIRRAAD PNDSKRGPVN 

       190        200        210        220        230        240 
AITPSVTVPS HHGPDVQTVI PINIETMAFV VPTTLMHVHS VMIELKKPIT REDVIDIFEN 

       250        260        270        280        290        300 
TTRVLLFEKE RGFESTAQLI EFARDLHREW NNLYEIAVWK ESISVKGNRL FYIQAVHQES 

       310        320        330 
DVVPENVDAI RAMFEMADKW ESIRKTNKSL GILK
Q5JHB5 in FASTA format

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