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UniProtKB/Swiss-Prot entry Q5L3K8

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ROCA_GEOKA
Primary accession number Q5L3K8
Secondary accession numbers None
Integrated into Swiss-Prot on January 15, 2008
Sequence was last modified on February 1, 2005 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 22)
Name and origin of the protein
Protein name 1-pyrroline-5-carboxylate dehydrogenase
Synonyms P5C dehydrogenase
EC 1.5.1.12
Gene name
Name: rocA
OrderedLocusNames: GK0187
From
Geobacillus kaustophilus [TaxID: 1462] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Bacillales; Bacillaceae; Geobacillus.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=HTA426;
DOI=10.1093/nar/gkh970; PubMed=15576355 [NCBI, ExPASy, EBI, Israel, Japan]
Takami H., Takaki Y., Chee G.-J., Nishi S., Shimamura S., Suzuki H., Matsui S., Uchiyama I.;
"Thermoadaptation trait revealed by the genome sequence of thermophilic Geobacillus kaustophilus.";
Nucleic Acids Res. 32:6292-6303(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
BA000043; BAD74472.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_146040.1; -.
3D structure databases
ModBase Q5L3K8.
Enzyme and pathway databases
BioCyc GKAU235909:GK0187-MON; -.
Ontologies
GO
GO:0003842; Molecular function: 1-pyrroline-5-carboxylate dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0006537; Biological process: glutamate biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00733; -; 1.
PBIL [Tree]
InterPro IPR016160; Ald_DHase_CS.
IPR016162; Ald_DHase_N.
IPR015590; Aldehyde_DHase.
IPR005932; d-1-pyrroline-5-COlate_DHase-2.
Graphical view of domain structure.
Gene3D G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
PANTHER PTHR11699; Aldehyde_dehyd; 1.
Pfam PF00171; Aldedh; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR01237; D1pyr5carbox2; 1.
PROSITE PS00070; ALDEHYDE_DEHYDR_CYS; 1.
PS00687; ALDEHYDE_DEHYDR_GLU; 1.
BLOCKS Q5L3K8.
Genome annotation databases
GeneID 3186084; -.
GenomeReviews BA000043_GR; GK0187.
KEGG gka:GK0187; -.
NMPDR fig|235909.3.peg.1485; -.
Phylogenomic databases
HOGENOM Q5L3K8; -.
Genome annotation databases
CMR Q5L3K8; GK0187.
Other
ProtoNet Q5L3K8.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; NAD; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   515  515     1-pyrroline-5-carboxylate dehydrogenase. PRO_1000045970
ACT_SITE   286   286        By similarity. 
ACT_SITE   320   320        By similarity. 
Sequence information
Length: 515 AA [This is the length of the unprocessed precursor] Molecular weight: 56667 Da [This is the MW of the unprocessed precursor] CRC64: 9E3253E0D5EB852E [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MVQPYRHEPL TDFTVEANRE AFLAALKKVE SELGRDYPLV IGGERVMTED KIISINPANK 

        70         80         90        100        110        120 
TEVVGRVAKA NKELAERAMK TADEAFRTWS RTSPEARADI LFRAAAIVRR RKHEFSAWLV 

       130        140        150        160        170        180 
KEAGKPWREA DADTAEAIDF MEYYGRQMLK LKDGIPVESR PGETNRFFYI PLGVGVVISP 

       190        200        210        220        230        240 
WNFPFAIMAG TTVASLVTGN TVLLKPASAT PVVAYKFVEV LEEAGLPAGV LNYIPGSGAE 

       250        260        270        280        290        300 
VGDYLVDHPR TRFISFTGSR DVGIRIYERA AKVHPGQIWL KRVIAEMGGK DAIVVDKEAD 

       310        320        330        340        350        360 
LELAAQSIVA SAFGFSGQKC SACSRAIIVE DVYDQVLSRV VELTKQLNVG DPAEQATFMG 

       370        380        390        400        410        420 
PVIDQNAYNK IMEYIEIGKQ EGRLMTGGEG DDAKGFFIQP TVFADVDPNA RIMQEEIFGP 

       430        440        450        460        470        480 
VVAFAKARDF DHALEIANNT EYGLTGAVIS RNRANLEKAR HEFHVGNLYF NRGCTGAIVG 

       490        500        510 
YQPFGGFNMS GTDSKAGGPD YLILHMQAKT VSEMF
Q5L3K8 in FASTA format

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