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UniProtKB/Swiss-Prot entry Q5LCI2


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name PYRD_BACFN
Primary accession number Q5LCI2
Secondary accession numbers None
Integrated into Swiss-Prot on January 15, 2008
Sequence was last modified on June 21, 2005 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 28)
Name and origin of the protein
Protein name Dihydroorotate dehydrogenase
Synonyms EC 1.3.3.1
Dihydroorotate oxidase
DHOdehase
DHODase
DHOD
Gene name
Name: pyrD
OrderedLocusNames: BF2483
From
Bacteroides fragilis (strain ATCC 25285 / NCTC 9343) [TaxID: 272559] [HAMAP proteome]
Taxonomy Bacteria; Bacteroidetes; Bacteroidetes (class); Bacteroidales; Bacteroidaceae; Bacteroides.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1126/science.1107008; PubMed=15746427 [NCBI, ExPASy, EBI, Israel, Japan]
Cerdeno-Tarraga A.-M., Patrick S., Crossman L.C., Blakely G., Abratt V., Lennard N., Poxton I., Duerden B., Harris B., Quail M.A., Barron A., Clark L., Corton C., Doggett J., Holden M.T.G., Larke N., Line A., Lord A., Norbertczak H., Ormond D., Price C., Rabbinowitsch E., Woodward J., Barrell B.G., Parkhill J.;
"Extensive DNA inversions in the B. fragilis genome control variable gene expression.";
Science 307:1463-1465(2005).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CR626927; CAH08183.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_212107.1; -.
3D structure databases
ModBase Q5LCI2.
Enzyme and pathway databases
BioCyc BFRA272559:BF2483-MON; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0004158; Molecular function: dihydroorotate oxidase activity (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00224; -; 1.
PBIL [Tree]
InterPro IPR013785; Aldolase_TIM.
IPR012135; DHO_DHase_1_2.
IPR005720; DHO_DHase_1_core.
IPR001295; Dihydroorotate_DHase_core.
Graphical view of domain structure.
Gene3D G3DSA:3.20.20.70; Aldolase_TIM; 1.
Pfam PF01180; DHO_dh; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000164; DHO_oxidase; 1.
TIGRFAMs TIGR01037; pyrD_sub1_fam; 1.
PROSITE PS00911; DHODEHASE_1; 1.
PS00912; DHODEHASE_2; 1.
BLOCKS Q5LCI2.
Genome annotation databases
GeneID 3289320; -.
GenomeReviews CR626927_GR; BF2483.
KEGG bfs:BF2483; -.
Phylogenomic databases
HOGENOM Q5LCI2; -.
Genome annotation databases
CMR Q5LCI2; BF2483.
Other
ProtoNet Q5LCI2.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Cytoplasm; Flavoprotein; FMN; Oxidoreductase; Pyrimidine biosynthesis.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   303  303     Dihydroorotate dehydrogenase. PRO_1000024127
ACT_SITE   130   130        Nucleophile (By similarity). 
Sequence information
Length: 303 AA [This is the length of the unprocessed precursor] Molecular weight: 32332 Da [This is the MW of the unprocessed precursor] CRC64: 92360403BBB5F984 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MADLSVNIGK LQMKNPVMTA SGTFGYGEEF ADFIDITRIG GIIVKGTTLH KREGNPYPRM 

        70         80         90        100        110        120 
AETPSGMLNA VGLQNKGVEY FSNHIYPRIK DIQTHMIVNV SGSAIEDYVK TAEIINELDK 

       130        140        150        160        170        180 
IPAIELNISC PNVKQGGMAF GVTTKGVSEV VQAVRSAYKK TLIVKLSPNV TDIAEMARAA 

       190        200        210        220        230        240 
EANGADSVSL INTLLGMAID AERKRPILST VTGGMSGAAV KPIALRMVWQ VAKAVNIPVI 

       250        260        270        280        290        300 
GLGGIMNWKD AVEFMLAGAS AIQIGTANFI DPAITIKVID GINDYLERHG CKSVSEIIGA 


LEV 

Q5LCI2 in FASTA format

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Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
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