[1]	NUCLEOTIDE SEQUENCE [MRNA]. Momozawa Y., Mori Y.; "Equus caballus monoamine oxidase A (MAOA), mRNA."; Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine (By similarity).
CATALYTIC ACTIVITY: RCH₂NH₂ + H₂O + O₂ = RCHO + NH₃ + H₂O₂.
COFACTOR: FAD (By similarity).
SUBUNIT: Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer (By similarity).
SUBCELLULAR LOCATION: Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side (By similarity).
SIMILARITY: Belongs to the flavin monoamine oxidase family.

Copyright

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Cross-references

Sequence databases

EMBL

AB178282; BAD80721.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_001075301.1; -.

UniGene

Eca.12721

3D structure databases

SMR

Q5NU32; 23-509.

ModBase

Q5NU32.

Family and domain databases

InterPro

IPR001613; Amineoxid_fl.
IPR002937; Amino_oxidase.
Graphical view of domain structure.

Pfam

PF01593; Amino_oxidase; 1.
Pfam graphical view of domain structure.

PRINTS

PR00757; AMINEOXDASEF.

BLOCKS

Q5NU32.

Genome annotation databases

GeneID

100033867; -.

Phylogenomic databases

HOVERGEN

Q5NU32; -.

Other

ProtoNet

Q5NU32.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Catecholamine metabolism; FAD; Flavoprotein; Membrane; Mitochondrion; Mitochondrion outer membrane; Neurotransmitter degradation; Oxidoreductase; Transmembrane.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 527`	`527`	`Amine oxidase [flavin-containing] A.`	`PRO_0000099849`
`TOPO_DOM`	`1 497`	`497`	`Cytoplasmic (Potential).`
`TRANSMEM`	`498 518`	`21`	`Anchor for type IV membrane protein (Potential).`
`TOPO_DOM`	`519 527`	`9`	`Mitochondrial intermembrane (Potential).`
`SITE`	`335 335`	`1`	`Important for substrate specificity (By similarity).`
`SITE`	`374 374`	`1`	`Important for catalytic activity (By similarity).`
`MOD_RES`	`406 406`		`S-8alpha-FAD cysteine (By similarity).`

Sequence information

Length: 527 AA [This is the length of the unprocessed precursor]

Molecular weight: 59580 Da [This is the MW of the unprocessed precursor]

CRC64: 177988F29564E35B [This is a checksum on the sequence]

        10         20         30         40         50         60 
MASQEKASMA GHMFDVVVIG GGISGLSAAK LLAEHETNVL VLEARDRVGG RTYTVRNKHV 

        70         80         90        100        110        120 
NYVDVGGAYV GPTQNRILRL SKELGLETYK VNVNERLVQY VKGKSYPFRG AFPPVWNPIA 

       130        140        150        160        170        180 
YLDYNNLWRT MDNMGKEIPA DAPWEAPHAE EWDKMTMKDL IDKICWTKTA RQFASLFVNI 

       190        200        210        220        230        240 
NVTSEPHQVS ALWFLWYVKQ CGGTTRIFSI TNGGQERKFV GGSGQVSERI MELLGDRVKL 

       250        260        270        280        290        300 
EHPVTYVDQS GDNIIVETLN HEHFECKYVI SAIPPALTAK IHFKPELPSE RNQLIQRLPM 

       310        320        330        340        350        360 
GAIIKCMMYY KEAFWKKKDY CGSMIIEDEE APISITLDDS KPDGSLPAIM GFILARKADR 

       370        380        390        400        410        420 
LAKLHKEMRK KKICELYAKV LGSQEALQPV HYEEKNWCEE QYSGGCYTAY FPPGIMTQYG 

       430        440        450        460        470        480 
RVIRQPVGRI YFAGTETATR WSGYMEGAVE AGERAAREIL NALGKVAEKD IWLQEPESKD 

       490        500        510        520 
VPAVEITHSF WERNLPSVGG LLKIIGFSTS ITALWIVVYK FKLLTRS

Q5NU32 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools