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UniProtKB/Swiss-Prot entry Q5P790

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HISX_AZOSE
Primary accession number Q5P790
Secondary accession numbers None
Integrated into Swiss-Prot on January 10, 2006
Sequence was last modified on January 4, 2005 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 27)
Name and origin of the protein
Protein name Histidinol dehydrogenase
Synonyms HDH
EC 1.1.1.23
Gene name
Name: hisD
OrderedLocusNames: AZOSEA06980
ORFNames: ebA1299
From
Azoarcus sp. (strain EbN1) (Aromatoleum aromaticum (strain EbN1)) [TaxID: 76114] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Betaproteobacteria; Rhodocyclales; Rhodocyclaceae; Azoarcus.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1007/s00203-004-0742-9; PubMed=15551059 [NCBI, ExPASy, EBI, Israel, Japan]
Rabus R., Kube M., Heider J., Beck A., Heitmann K., Widdel F., Reinhardt R.;
"The genome sequence of an anaerobic aromatic-degrading denitrifying bacterium, strain EbN1.";
Arch. Microbiol. 183:27-36(2005).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CR555306; CAI06821.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_157722.1; -.
3D structure databases
ModBase Q5P790.
Enzyme and pathway databases
BioCyc ASP76114:EBA1299-MON; -.
Ontologies
GO
GO:0004399; Molecular function: histidinol dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0000105; Biological process: histidine biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_01024; -; 1.
PBIL [Tree]
InterPro IPR001692; Histidinol_DHase.
IPR012131; Hstdl_DHase_prok.
IPR002035; VWF_A.
Graphical view of domain structure.
PANTHER PTHR21256:SF2; Hstdl_DH_prok; 1.
Pfam PF00815; Histidinol_dh; 1.
Pfam graphical view of domain structure.
PRINTS PR00083; HOLDHDRGNASE.
PR00453; VWFADOMAIN.
ProDom PD002680; Histidinol_dh; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR00069; hisD; 1.
PROSITE PS00611; HISOL_DEHYDROGENASE; 1.
BLOCKS Q5P790.
Genome annotation databases
GeneID 3179686; -.
GenomeReviews CR555306_GR; AZOSEA06980.
KEGG eba:ebA1299; -.
NMPDR fig|76114.4.peg.2011; -.
Phylogenomic databases
HOGENOM Q5P790; -.
Genome annotation databases
CMR Q5P790; AZOSEA06980.
Other
ProtoNet Q5P790.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Complete proteome; Histidine biosynthesis; Metal-binding; NAD; Oxidoreductase; Zinc.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   438  438     Histidinol dehydrogenase. PRO_0000135718
ACT_SITE   334   334        Proton acceptor (By similarity). 
ACT_SITE   335   335        Proton acceptor (By similarity). 
METAL   266   266        Zinc (By similarity). 
METAL   269   269        Zinc (By similarity). 
METAL   368   368        Zinc (By similarity). 
METAL   427   427        Zinc (By similarity). 
BINDING   137   137        NAD (By similarity). 
BINDING   198   198        NAD (By similarity). 
BINDING   221   221        NAD (By similarity). 
BINDING   244   244        Substrate (By similarity). 
BINDING   266   266        Substrate (By similarity). 
BINDING   269   269        Substrate (By similarity). 
BINDING   335   335        Substrate (By similarity). 
BINDING   368   368        Substrate (By similarity). 
BINDING   422   422        Substrate (By similarity). 
BINDING   427   427        Substrate (By similarity). 
Sequence information
Length: 438 AA [This is the length of the unprocessed precursor] Molecular weight: 46793 Da [This is the MW of the unprocessed precursor] CRC64: 4416060B3F732E8A [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MTAPAAAIRR LDAREPEFLA TLDALLAFEG GADARIDAAV SEILRAVRTT GDAAVLEYTR 

        70         80         90        100        110        120 
RFDHLDVKSM VQLELSKSEL KAALDSLTVE QREALRVAAD RVRVYHERQR AESWDYVEAD 

       130        140        150        160        170        180 
GTRLGQKVTP LDRVGLYVPG GRASYPSSVL MNAIPAKVAG VGELIMVVPT PNGEKNPLVL 

       190        200        210        220        230        240 
AAAAITGVDR VFTIGGAQAV AALAYGTQTL PQVDKIVGPG NAYVAEAKRR VFGTVGIDMV 

       250        260        270        280        290        300 
AGPSEVLIIS DGSGQAGWVA MDLFAQAEHD ELAQSILLCT DAGFIDAVAA SIERLLPSMP 

       310        320        330        340        350        360 
RRETIAASLA NRGALIHVDS LEQACAIANR IAPEHLELSL DDAEPWIGRI RHAGAIFVGH 

       370        380        390        400        410        420 
WSVEALGDYC AGPNHVLPTM RSARFSSPLG VYDFQKRTSI VQISEAGAQT LGRVASILAR 

       430 
GEGLQAHARS AEMRLHDR
Q5P790 in FASTA format

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