[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. TISSUE=Testis; DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan] The MGC Project Team; "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."; Genome Res. 14:2121-2127(2004).

Comments

CATALYTIC ACTIVITY: L-proline + NAD(P)⁺ = 1-pyrroline-5-carboxylate + NAD(P)H.
PATHWAY: Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1 .
SUBUNIT: Homodecamer; composed of 5 homodimers (By similarity).
SIMILARITY: Belongs to the pyrroline-5-carboxylate reductase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

BC087166; AAH87166.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_001011993.1; -.

UniGene

Rn.40859

3D structure databases

ModBase

Q5PQJ6.

Organism-specific databases

RGD

1309115; Pycrl.

Gene expression databases

ArrayExpress

Q5PQJ6; -.

Family and domain databases

InterPro

IPR016040; NAD(P)-bd.
IPR004455; NADP_OxRdtase_F420.
IPR000304; P5CR.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.50.720; NAD(P)-bd; 1.

PANTHER

PTHR11645; P5CR; 1.

Pfam

PF03807; F420_oxidored; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF000193; Pyrrol-5-carb_rd; 1.

TIGRFAMs

TIGR00112; proC; 1.

PROSITE

PS00521; P5CR; FALSE_NEG.

BLOCKS

Q5PQJ6.

Genome annotation databases

Ensembl

ENSRNOG00000008708; Rattus norvegicus. [Contig view]

GeneID

300035; -.

KEGG

rno:300035; -.

Phylogenomic databases

HOVERGEN

Q5PQJ6; -.

Other

ProtoNet

Q5PQJ6.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Amino-acid biosynthesis; NADP; Oxidoreductase; Proline biosynthesis.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 274`	`274`		`Pyrroline-5-carboxylate reductase 3.`	`PRO_0000324564`

Sequence information

Length: 274 AA [This is the length of the unprocessed precursor]

Molecular weight: 28878 Da [This is the MW of the unprocessed precursor]

CRC64: 0DE4B1076C12B7AE [This is a checksum on the sequence]

        10         20         30         40         50         60 
MADEMSEPRR VGFVGAGRMA EAIAQGLIRA GKVEAKQVLA SAPTDKNLCH FRALGCQTTH 

        70         80         90        100        110        120 
SNHEVLQNCP LVIFATKPQV LPAVLAEVAP VVTTEHIIVS VAAGISLSSM EELLPPKTRV 

       130        140        150        160        170        180 
LRVSPNLPCV VQEGAMVMTR GHHAGNEDAK LLQNLLEACG QCIEVPESYV DIHTGLSGSG 

       190        200        210        220        230        240 
VAFVCTFSEA LAEGAIKMGM PSDLAHRIAA QTLLGTAKML QQEGKHPAQL RTDVLTPAGT 

       250        260        270 
TIHGLHALEQ GGFRAAAMSA VEAATCRAKE LSKK

Q5PQJ6 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools