[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. TISSUE=Brain cortex; The German cDNA consortium; Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process. Orthoquinones are the best substrates. May act in the detoxification of xenobiotics (By similarity).
CATALYTIC ACTIVITY: NADPH + quinone = NADP⁺ + semiquinone.
SUBUNIT: Homotetramer (By similarity).
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

Copyright

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Cross-references

Sequence databases

EMBL

CR861167; CAH93239.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

SMR

Q5R4S7; 6-329.

ModBase

Q5R4S7.

Family and domain databases

InterPro

IPR013154; AlcDHase_GroES-like.
IPR002085; AlcDHase_SF_Zn.
IPR013149; AlcDHase_Zn-bd.
IPR016040; NAD(P)-bd.
IPR002364; Quin_OxRdtase/zeta-crystal_CS.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.50.720; NAD(P)-bd; 1.

PANTHER

PTHR11695; ADH_Sf_Zn; 1.

Pfam

PF08240; ADH_N; 1.
PF00107; ADH_zinc_N; 1.
Pfam graphical view of domain structure.

PROSITE

PS01162; QOR_ZETA_CRYSTAL; 1.

BLOCKS

Q5R4S7.

Phylogenomic databases

HOVERGEN

Q5R4S7; -.

Other

ProtoNet

Q5R4S7.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Cytoplasm; NADP; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 329`	`329`		`Quinone oxidoreductase.`	`PRO_0000160909`

Sequence information

Length: 329 AA [This is the length of the unprocessed precursor]

Molecular weight: 35083 Da [This is the MW of the unprocessed precursor]

CRC64: 6C0E97E7F832F7D9 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MATGQKLMRA VRVFEFGGPE VLKLQSDIAV PIPKDHQALI KVHACGVNPV ETYIRSGTYS 

        70         80         90        100        110        120 
RKPLLPYTPG SDVAGVIEAV GGNASAFKKG DRVFTSSTIS GGYAEYALAA DHTVYKLPEK 

       130        140        150        160        170        180 
LDFKQGAAIG IPYFTAYRAL IHSAHVKAGE SVLVHGASGG VGLAACQIAR AYGLKVLGTA 

       190        200        210        220        230        240 
GTEEGQKIVL QNGAHEVFNH REVNYIDKIK KYVGEKGIDV IIEMLANVNL NKDLSLLSHG 

       250        260        270        280        290        300 
GQVIVVGSRG TIEINPRDTM AKESSIIGVT VFSSTKEEFQ QYAAALQAGM EIGWLKPVIG 

       310        320 
SQYPLEKVAE AHENIIHGSG ATGKMILLL

Q5R4S7 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools