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UniProtKB/Swiss-Prot entry Q5R5F3

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DHSO_PONAB
Primary accession number Q5R5F3
Secondary accession numbers None
Integrated into Swiss-Prot on September 11, 2007
Sequence was last modified on December 21, 2004 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 26)
Name and origin of the protein
Protein name Sorbitol dehydrogenase
Synonyms EC 1.1.1.14
L-iditol 2-dehydrogenase
Gene name
Name: SORD
From
Pongo abelii (Sumatran orangutan) [TaxID: 9601] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pongo.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Kidney;
The German cDNA consortium;
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CR860908; CAH93013.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
3D structure databases
SMR Q5R5F3; 2-357.
ModBase Q5R5F3.
Ontologies
GO
GO:0003939; Molecular function: L-iditol 2-dehydrogenase activity (inferred from electronic annotation from EC).
QuickGo view.
Family and domain databases
InterPro IPR013154; AlcDHase_GroES-like.
IPR002085; AlcDHase_SF_Zn.
IPR013149; AlcDHase_Zn-bd.
IPR002328; AlcDHase_Zn_CS.
Graphical view of domain structure.
PANTHER PTHR11695; ADH_Sf_Zn; 1.
Pfam PF08240; ADH_N; 1.
PF00107; ADH_zinc_N; 1.
Pfam graphical view of domain structure.
PROSITE PS00059; ADH_ZINC; 1.
BLOCKS Q5R5F3.
Phylogenomic databases
HOVERGEN Q5R5F3; -.
Other
ProtoNet Q5R5F3.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Acetylation; Metal-binding; NAD; Oxidoreductase; Zinc.
Features
SEVIEWER logo Feature table viewer
KeyFrom  To Length Description FTId
INIT_MET   1     1        Removed (By similarity). 
CHAIN   2   357  356     Sorbitol dehydrogenase. PRO_0000301685
METAL   45    45        Zinc (catalytic) (By similarity). 
METAL   70    70        Zinc (catalytic) (By similarity). 
METAL   71    71        Zinc (catalytic) (By similarity). 
MOD_RES   2     2        N-acetylalanine (By similarity). 
Sequence information
Length: 357 AA [This is the length of the unprocessed precursor] Molecular weight: 38212 Da [This is the MW of the unprocessed precursor] CRC64: 630FB00DE09BC886 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MAAAAKPSNL SLVVHGPGDL RLENYPIPEP GPNEVLLRMH SVGICGSDVH YWEDGRIGNF 

        70         80         90        100        110        120 
IVKKPMVLGH EASGTVEKVG SLVKHLKPGD RVAIEPGAPR ENDEFCKIGR YNLSPSIFFC 

       130        140        150        160        170        180 
ATPPDDGNLC RFYKHNAAFC YKLPDNVTFE EGAMIEPLSV GIHACRRGGV TLGHKVLVCG 

       190        200        210        220        230        240 
AGPIGMVTLL VAKAMGAAQV VVTDLSATRL SKAKEIGADL VLQISKESPQ EIARKVEGLL 

       250        260        270        280        290        300 
GCKPEVTIEC TGAGASIQAG IYATHSGGTL VLVGLGSEMT TIPLLHAAIR EVDIKGVFRY 

       310        320        330        340        350 
CNTWPVAISM LASKSVNVKP LITHRFPLEK ALEAFETFKK GLGLKIMLKC DPNDQNP
Q5R5F3 in FASTA format

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