FUNCTION: The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).
CATALYTIC ACTIVITY: 2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO₂.
COFACTOR: Thiamine pyrophosphate (By similarity).
SUBCELLULAR LOCATION: Mitochondrion (Potential).
SIMILARITY: Belongs to the alpha-ketoglutarate dehydrogenase family.

Copyright

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Cross-references

Sequence databases

EMBL

CR860147; CAH92290.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

ModBase

Q5R7H0.

Family and domain databases

InterPro

IPR011603; 2oxoglutarate_DHase_E1.
IPR001017; DHase_E1.
IPR005475; Transketo_Cen_R.
Graphical view of domain structure.

PANTHER

PTHR23152; 2oxoglutarate_DH_E1; 1.

Pfam

PF00676; E1_dh; 1.
PF02779; Transket_pyr; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF000157; Oxoglu_dh_E1; 1.

TIGRFAMs

TIGR00239; 2oxo_dh_E1; 1.

BLOCKS

Q5R7H0.

Phylogenomic databases

HOVERGEN

Q5R7H0; -.

Other

ProtoNet

Q5R7H0.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Glycolysis; Mitochondrion; Oxidoreductase; Thiamine pyrophosphate; Transit peptide.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`TRANSIT`	`1 ?`		`Mitochondrion (Potential).`
`CHAIN`	`? 919`		`Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial.`	`PRO_0000307938`

Sequence information

Length: 919 AA [This is the length of the unprocessed precursor]

Molecular weight: 103036 Da [This is the MW of the unprocessed precursor]

CRC64: 6F111B5B0A5A3198 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MASATAAAAR RCLGRAPPLL WRGYQTERGV YGYRPRKPES RKPQGALERP PVDHGLARLV 

        70         80         90        100        110        120 
TVYREHGHKA AKINPLFTGQ ALLENVPEIQ ALVQTLQGPF HTAGLLNMGK EEASLEEVLV 

       130        140        150        160        170        180 
YLNQIYCGQI SIETSQLQSQ EEKDWFAKRF EELQKETFTT EERKHLSKLM LESQEFDHFL 

       190        200        210        220        230        240 
ATKFSTVKRY GGEGAESMMG FFYELLKMSA YSGITDVIIG MPHRGRLNLL TGLLQFPPEL 

       250        260        270        280        290        300 
MFRKMRGLSE FPENFSATGD VLSHLTSSVD LDFGAHHPLH VTMLPNPSHL EAVNPVAVGK 

       310        320        330        340        350        360 
TRGRQQSRQD GDYSPDNSAQ PGDRVICLQV HGDASFCGQG IVPETFTLSN LPHFRIGGSV 

       370        380        390        400        410        420 
HLIVNNQLGY TTPAERGRSS LYCSDIGKLV GCAIIHVNGD SPEEVVRATR LAFEYQRQFR 

       430        440        450        460        470        480 
KDVIIDLLCY RQWGHNELDE PFFTNPIMYK IIRARKSIPD TYAEHLIAGG LMTQEEVSEI 

       490        500        510        520        530        540 
KSSYYAKLND HLNNMAHYSP PAQNLQAHWQ GLAQPEARIT TWSTGVPLDL LRFVGVKSVE 

       550        560        570        580        590        600 
VPRQLQMHSH LLKTHVQSRM EKVMDGTKLD WATAEALALG SLLAQGFNVR LSGQDVGRGT 

       610        620        630        640        650        660 
FSQRHAMVVC QETDDTYIPL NHMDPNQKGF LEVSNSPLSE EAVLGFEYGM SIESPKLLPL 

       670        680        690        700        710        720 
WEAQFGDFFN GAQIIFDTFI SGGEAKWLLQ SGIVTLLPHG HDGAGPDHSS CRIERFLQMC 

       730        740        750        760        770        780 
DSAEEGVDGD TVNMFVVHPT TPAQYFHLLR RQMVRNFRKP LIVASPKMLL RLPAAVSTLQ 

       790        800        810        820        830        840 
EMAPGTTFNP VIGDSSVDPK KVKTLVFCSG KHFYSLMKQR ESLGAKKHDF AIIRVEELCP 

       850        860        870        880        890        900 
FPLDSLQQEM SKYKHVKDHI WSQEEPQNMG PWLFVSPRFE KQLACKLRLV GRPPLPVPAV 

       910 
GIGTVHLHQH EDILAKTFA

Q5R7H0 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools