FUNCTION: Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine (By similarity).
CATALYTIC ACTIVITY: RCH₂NH₂ + H₂O + O₂ = RCHO + NH₃ + H₂O₂.
COFACTOR: FAD (By similarity).
SUBUNIT: Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer (By similarity).
SUBCELLULAR LOCATION: Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side (By similarity).
SIMILARITY: Belongs to the flavin monoamine oxidase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

CR857341; CAH89637.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
CR857677; CAH89947.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

SMR

Q5RE60; 23-509.

ModBase

Q5RE60.

Ontologies

GO:0005741;	Cellular component: mitochondrial outer membrane (inferred from electronic annotation from UniProtKB-SubCell).
GO:0008131;	Molecular function: amine oxidase activity (inferred from electronic annotation from EC).
QuickGo view.

Family and domain databases

InterPro

IPR001613; Amineoxid_fl.
IPR002937; Amino_oxidase.
Graphical view of domain structure.

Pfam

PF01593; Amino_oxidase; 1.
Pfam graphical view of domain structure.

PRINTS

PR00757; AMINEOXDASEF.

BLOCKS

Q5RE60.

Phylogenomic databases

HOVERGEN

Q5RE60; -.

Other

ProtoNet

Q5RE60.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Catecholamine metabolism; FAD; Flavoprotein; Membrane; Mitochondrion; Mitochondrion outer membrane; Neurotransmitter degradation; Oxidoreductase; Transmembrane.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 527`	`527`	`Amine oxidase [flavin-containing] A.`	`PRO_0000099853`
`TOPO_DOM`	`1 497`	`497`	`Cytoplasmic (Potential).`
`TRANSMEM`	`498 518`	`21`	`Anchor for type IV membrane protein (Potential).`
`TOPO_DOM`	`519 527`	`9`	`Mitochondrial intermembrane (Potential).`
`SITE`	`335 335`	`1`	`Important for substrate specificity (By similarity).`
`SITE`	`374 374`	`1`	`Important for catalytic activity (By similarity).`
`MOD_RES`	`406 406`		`S-8alpha-FAD cysteine (By similarity).`
`CONFLICT`	`382 382`		`G -> E (in Ref. 1; CAH89637).`

Sequence information

Length: 527 AA [This is the length of the unprocessed precursor]

Molecular weight: 59666 Da [This is the MW of the unprocessed precursor]

CRC64: 8CC74D22F867CE8F [This is a checksum on the sequence]

        10         20         30         40         50         60 
MENQEKASIA GHMFDVVVIG GGISGLSAAK LLTEYGVSVL VLEARDRVGG RTYTIRNEHV 

        70         80         90        100        110        120 
DYVDVGGAYV GPTQNRILRL SKELGIETYK VNVSERLVQY VKGKTYPFRG AFPPVWNPIA 

       130        140        150        160        170        180 
YLDYNNLWRT IDNMGKEIPA DAPWEAQHAD EWDKMTMKEL IDKICWTKTA RRFAYLFVNI 

       190        200        210        220        230        240 
NVTSEPHEVS ALWFLWYVKQ CGGTTRIFSV TNGGQERKFV GGSGQVSERI MDLLGDQVKL 

       250        260        270        280        290        300 
NHPVTHVDQS SNNIIIETLN HEHYECKYVI NAIPPTLTAK IHFRPELPAE RNQLIQRLPM 

       310        320        330        340        350        360 
GAIIKCMMYY KEAFWKKKDY CGCMIIEDED APISITLDDT KPDGSLPAIM GFILARKADR 

       370        380        390        400        410        420 
LAKLHKEIRK KKICELYAKV LGSQEALHPV HYEEKNWCEE QYSGGCYTAY FPPGIMTQYG 

       430        440        450        460        470        480 
RVIRQPVGRI FFAGTETATK WSGYMEGAVE AGERAAREVL NGLGKVTEKD IWVQEPESKD 

       490        500        510        520 
VPAVEITHTF WERNLPSVSG LLKIIGFSTS VTALGFVLYK YKLLPRS

Q5RE60 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools