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UniProtKB/Swiss-Prot entry Q5RF00

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ALDH2_PONAB
Primary accession number Q5RF00
Secondary accession numbers None
Integrated into Swiss-Prot on December 4, 2007
Sequence was last modified on December 21, 2004 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 21)
Name and origin of the protein
Protein name Aldehyde dehydrogenase, mitochondrial [Precursor]
Synonyms EC 1.2.1.3
ALDH class 2
ALDH-E2
Gene name
Name: ALDH2
From
Pongo abelii (Sumatran orangutan) [TaxID: 9601] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pongo.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Kidney;
The German cDNA consortium;
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CR857362; CAH89657.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
3D structure databases
SMR Q5RF00; 24-517.
ModBase Q5RF00.
Ontologies
GO
GO:0005759; Cellular component: mitochondrial matrix (inferred from electronic annotation from UniProtKB-SubCell).
GO:0004029; Molecular function: aldehyde dehydrogenase (NAD) activity (inferred from electronic annotation from EC).
QuickGo view.
Family and domain databases
InterPro IPR016160; Ald_DHase_CS.
IPR016162; Ald_DHase_N.
IPR015590; Aldehyde_DHase.
Graphical view of domain structure.
Gene3D G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
PANTHER PTHR11699; Aldehyde_dehyd; 1.
Pfam PF00171; Aldedh; 1.
Pfam graphical view of domain structure.
PROSITE PS00070; ALDEHYDE_DEHYDR_CYS; 1.
PS00687; ALDEHYDE_DEHYDR_GLU; 1.
BLOCKS Q5RF00.
Phylogenomic databases
HOVERGEN Q5RF00; -.
Other
ProtoNet Q5RF00.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Acetylation; Mitochondrion; NAD; Oxidoreductase; Transit peptide.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
TRANSIT   1    17  17     Mitochondrion (By similarity). 
CHAIN   18   517  500     Aldehyde dehydrogenase, mitochondrial. PRO_0000312493
NP_BIND   262   267  6     NAD (By similarity). 
ACT_SITE   285   285        Proton acceptor (By similarity). 
ACT_SITE   319   319        Nucleophile (By similarity). 
SITE   186   186  1     Transition state stabilizer (By similarity). 
MOD_RES   18    18        N-acetylserine (By similarity). 
MOD_RES   368   368        N6-acetyllysine (By similarity). 
Sequence information
Length: 517 AA [This is the length of the unprocessed precursor] Molecular weight: 56380 Da [This is the MW of the unprocessed precursor] CRC64: E8F74D4CFA27220E [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MLRAAARFGP RLGRRLLSAA ATQAVPAPNQ QPEVFCNQIF INNEWHDAVS RKTFPTVNPS 

        70         80         90        100        110        120 
TGEVICQVAE GDKEDVDKAV KAARAAFQLG SPWRRMDASH RGRLLNRLAD LIERDRTYLA 

       130        140        150        160        170        180 
ALETLDNGKP YVISYLVDLD MVLKCLRYYA GWADKYHGKT IPIDGDFFSY TRHEPVGVCG 

       190        200        210        220        230        240 
QIIPWNFPLL MQAWKLGPAL ATGNVVVMKV AEQTPLTALY VANLIKEAGF PPGVVNIVPG 

       250        260        270        280        290        300 
FGPTAGAAIA SHEDVDKVAF TGSTEIGRVI QVAAGSSNLK RVTLELGGKS PNIIMSDADM 

       310        320        330        340        350        360 
DWAVEQAHFA LFFNQGQCCC AGSRTFVQED IYDEFVERSV ARAKSRVVGN PFDSKTEQGP 

       370        380        390        400        410        420 
QVDETQFKKI LGYINTGKQE GAKLLCGGGI AADRGYFIQP TVFGDVQDGM TIAKEEIFGP 

       430        440        450        460        470        480 
VMQILKFKTI EEVVGRANNS TYGLAAAVFT KDLDKANYLS QALQAGTVWV NCYNVFGAQS 

       490        500        510 
PFGGYKMSGS GRELGEYGLQ AYTEVKTVTV KVPQKNS
Q5RF00 in FASTA format

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