[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. TISSUE=Liver; NIH - Xenopus Gene Collection (XGC) project; Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.

Comments

CATALYTIC ACTIVITY: L-tryptophan + O₂ = N-formyl-L-kynurenine.
COFACTOR: Binds 2 heme groups per tetramer. The hemes are protoheme IV (By similarity).
PATHWAY: Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 1/2 .
SIMILARITY: Belongs to the tryptophan 2,3-dioxygenase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

BC084948; AAH84948.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_001088604.1; -.

UniGene

Xl.14845

3D structure databases

ModBase

Q5U4U6.

Family and domain databases

InterPro

IPR004981; Trp_2_3_dOase.
Graphical view of domain structure.

PANTHER

PTHR10138; Trp_2_3_dOase; 1.

Pfam

PF03301; Trp_dioxygenase; 1.
Pfam graphical view of domain structure.

BLOCKS

Q5U4U6.

Genome annotation databases

GeneID

495495; -.

KEGG

xla:495495; -.

Phylogenomic databases

HOVERGEN

Q5U4U6; -.

Other

ProtoNet

Q5U4U6.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Dioxygenase; Heme; Iron; Metal-binding; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 406`	`406`		`Tryptophan 2,3-dioxygenase.`	`PRO_0000247476`

Sequence information

Length: 406 AA [This is the length of the unprocessed precursor]

Molecular weight: 47677 Da [This is the MW of the unprocessed precursor]

CRC64: 54C81EAE30A944AE [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSGCPFMAKK HHFTFSELSL EDKHEDNSQE GLNKASKGGL IYGDYLQLDK VLNAQELQSE 

        70         80         90        100        110        120 
KKGNKIHDEH LFIVTHQAYE LWFKQILWEL DSVREIFQNG HVRDERNMLK VVARIHRISM 

       130        140        150        160        170        180 
ILKLLVEQFS VLETMTAMDF FDFRDYLSPA SGFQSLQFRL LENKIGVPEI LRVPYNRRHY 

       190        200        210        220        230        240 
RDNFKGETNE LLLRSEQEPT LLGLVEAWLE RTPGLEEEGF HFWGKLEVNI FRALEEELQA 

       250        260        270        280        290        300 
AKTKPDSEDK EEHLAELQKQ KELFGALFDE RRHEHLLSKG ERRLSYKALK GALMINFYRE 

       310        320        330        340        350        360 
EPRFQVPFQL LTSLMEIDTL MTKWRYNHVC MVHRMIGSKA GTGGSSGYQY LRSTVSDRYK 

       370        380        390        400 
VFVDLFNLST YLVPRHWVPR LNPSIHKFLY TAECCDSSYF SSDDSD

Q5U4U6 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools