[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. STRAIN=cv. Nipponbare; The international rice genome sequencing project (IRGSP) consortium; "Oryza sativa nipponbare chromosome 6 genomic DNA sequence."; Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases.
[2]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. STRAIN=cv. Nipponbare; DOI=10.1126/science.1081288; PubMed=12869764 [NCBI, ExPASy, EBI, Israel, Japan] The rice full-length cDNA consortium; "Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice."; Science 301:376-379(2003).

Comments

CATALYTIC ACTIVITY: Homogentisate + O₂ = 4-maleylacetoacetate.
COFACTOR: Iron (By similarity).
PATHWAY: Amino-acid degradation; L-phenylalanine degradation; acetoacetic acid and fumarate from L-phenylalanine: step 4/6 .
SIMILARITY: Belongs to the homogentisate dioxygenase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AP002842; BAD67951.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AK065189; -; NOT_ANNOTATED_CDS; mRNA.	[EMBL / GenBank / DDBJ]

RefSeq

NP_001056540.1; -.

UniGene

Os.11622

3D structure databases

ModBase

Q5VRH4.

Organism-specific databases

Gramene

Q5VRH4; -.

Family and domain databases

InterPro

IPR005708; Homogentis_dOase.
Graphical view of domain structure.

PANTHER

PTHR11056; Homogentis_dOase; 1.

Pfam

PF04209; HgmA; 1.
Pfam graphical view of domain structure.

TIGRFAMs

TIGR01015; hmgA; 1.

BLOCKS

Q5VRH4.

Genome annotation databases

GeneID

4339844; -.

KEGG

osa:4339844; -.

Other

ProtoNet

Q5VRH4.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Dioxygenase; Iron; Metal-binding; Oxidoreductase; Phenylalanine catabolism; Tyrosine catabolism.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 470`	`470`	`Homogentisate 1,2-dioxygenase.`	`PRO_0000247478`
`METAL`	`356 356`		`Iron (By similarity).`
`METAL`	`362 362`		`Iron (By similarity).`
`METAL`	`392 392`		`Iron (By similarity).`
`CONFLICT`	`421 421`		`M -> V (in Ref. 2).`

Sequence information

Length: 470 AA [This is the length of the unprocessed precursor]

Molecular weight: 51771 Da [This is the MW of the unprocessed precursor]

CRC64: 9C2148F4ABB079E4 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MAMATATPAA QNEQQEKGGL EYVYLSGLGN SLSSEAVAGT LPRGQNSPLV CPLGLYAEQL 

        70         80         90        100        110        120 
SGTPFTAPRA RNLRTWLYRI KPSVTHEPFH PRRPAHPRLI GDFDRTTTDT VATPTQLRWR 

       130        140        150        160        170        180 
PADVPPHHPP LDFIDGLYTV CGAGSSFLRH GYAIHMYAAN KSMDGCAFCN ADGDFLIVPQ 

       190        200        210        220        230        240 
QGKLLITTEC GKLLVPPGEI VVIPQGFRFA VDLPDGPSRG YVSEIFGTHF QLPDLGPIGA 

       250        260        270        280        290        300 
NGLASARDFL SPTAWFEQVH RPGYTIVQKY GGELFTATQD FSPFNVVAWH GNYVPYKYDL 

       310        320        330        340        350        360 
SKFCPFNTVL FDHADPSVNT VLTAPTDKPG VALLDFVIFP PRWLVAENTF RPPYYHRNCM 

       370        380        390        400        410        420 
SEFMGLIYGI YEAKADGFLP GGASLHSCMT PHGPDTKTYE ATISRPDANE PSRLSGTLAF 

       430        440        450        460        470 
MFESALIPRV CQWALDSPSR DLDYYQCWIG LKSHFSHDNG GATSEEPCRK

Q5VRH4 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools