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UniProtKB/Swiss-Prot entry Q5WX50

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HGD_LEGPL
Primary accession number Q5WX50
Secondary accession numbers None
Integrated into Swiss-Prot on March 7, 2006
Sequence was last modified on November 23, 2004 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 28)
Name and origin of the protein
Protein name Homogentisate 1,2-dioxygenase
Synonyms EC 1.13.11.5
Homogentisicase
Homogentisate oxygenase
Homogentisic acid oxidase
Gene name
Name: hmgA
OrderedLocusNames: lpl1248
From
Legionella pneumophila (strain Lens) [TaxID: 297245] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Legionellales; Legionellaceae; Legionella.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/ng1447; PubMed=15467720 [NCBI, ExPASy, EBI, Israel, Japan]
Cazalet C., Rusniok C., Brueggemann H., Zidane N., Magnier A., Ma L., Tichit M., Jarraud S., Bouchier C., Vandenesch F., Kunst F., Etienne J., Glaser P., Buchrieser C.;
"Evidence in the Legionella pneumophila genome for exploitation of host cell functions and high genome plasticity.";
Nat. Genet. 36:1165-1173(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CR628337; CAH15487.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_126599.1; -.
3D structure databases
ModBase Q5WX50.
Enzyme and pathway databases
BioCyc LPNE297245:LPL1248-MON; -.
Organism-specific databases
LegioList lpl1248; -.
Ontologies
GO
GO:0004411; Molecular function: homogentisate 1,2-dioxygenase activity (inferred from electronic annotation from HAMAP).
GO:0005506; Molecular function: iron ion binding (inferred from electronic annotation from HAMAP).
GO:0006559; Biological process: L-phenylalanine catabolic process (inferred from electronic annotation from HAMAP).
GO:0006572; Biological process: tyrosine catabolic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00334; -; 1.
PBIL [Tree]
InterPro IPR005708; Homogentis_dOase.
Graphical view of domain structure.
PANTHER PTHR11056; Homogentis_dOase; 1.
Pfam PF04209; HgmA; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR01015; hmgA; 1.
BLOCKS Q5WX50.
Genome annotation databases
GeneID 3114748; -.
GenomeReviews CR628337_GR; lpl1248.
KEGG lpf:lpl1248; -.
NMPDR fig|297245.3.peg.2453; -.
Phylogenomic databases
HOGENOM Q5WX50; -.
Genome annotation databases
CMR Q5WX50; lpl1248.
Other
ProtoNet Q5WX50.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Dioxygenase; Iron; Metal-binding; Oxidoreductase; Phenylalanine catabolism; Tyrosine catabolism.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   416  416     Homogentisate 1,2-dioxygenase. PRO_0000225789
METAL   318   318        Iron (By similarity). 
METAL   324   324        Iron (By similarity). 
METAL   354   354        Iron (By similarity). 
Sequence information
Length: 416 AA [This is the length of the unprocessed precursor] Molecular weight: 47451 Da [This is the MW of the unprocessed precursor] CRC64: 19BEAF0E3A153641 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MYLQGFGNYH HSEAVKGALP PNQNSPQHCS LGLYAEQLSG TSFTRPRHNN LRSWLYRILP 

        70         80         90        100        110        120 
TVTQGTYYPY EFNIMQPLVD ELSPNAMRWS PLYNSSQIKC DFVEGLFHIA GSPLVNAYTY 

       130        140        150        160        170        180 
YCNHSMSDKY FANNDGELLF VPYTGEIHLH TEFGKLMLSS GSIAVIPRGV KFKVEVISKE 

       190        200        210        220        230        240 
AKGYLCENSG NPLTLPQLGP IGANGLANPR HFQYPVAAFE NSVGEHTIIC KNQKKLWFTV 

       250        260        270        280        290        300 
CNHSPLNVVA WHGNYAPYCY DLSLFNTINT VSFDHPDPSI FTVLTSESEI PGVSNLDFVI 

       310        320        330        340        350        360 
FPPRWMVAEH TFRPPYFHRN YMNELMGLVY GEYDAKKEGF IPGGISIHNC MTPHGPDYES 

       370        380        390        400        410 
YEIAASQDLK PNYINSLAFM FETKDYWQVT EQAYRHPSRQ IDYLNCWQGF KIEFSQ
Q5WX50 in FASTA format

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