[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. TISSUE=Temporal cortex; Kusuda J., Osada N., Tanuma R., Hirata M., Sugano S., Hashimoto K.; "Isolation and characterization of cDNA for macaque neurological disease genes."; Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: Catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine (By similarity).
CATALYTIC ACTIVITY: 5-methyltetrahydrofolate + NAD(P)⁺ = 5,10-methylenetetrahydrofolate + NAD(P)H.
COFACTOR: FAD (By similarity).
ENZYME REGULATION: Allosterically regulated by S-adenosylmethionine (By similarity).
PATHWAY: One-carbon metabolism; tetrahydrofolate pathway .
SUBUNIT: Homodimer (By similarity).
SIMILARITY: Belongs to the methylenetetrahydrofolate reductase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AB125182; BAD51970.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

ModBase

Q60HE5.

Family and domain databases

InterPro

IPR004621; Fadh2_euk.
IPR003171; Mehydrof_redctse.
Graphical view of domain structure.

Pfam

PF02219; MTHFR; 1.
Pfam graphical view of domain structure.

TIGRFAMs

TIGR00677; fadh2_euk; 1.

BLOCKS

Q60HE5.

Phylogenomic databases

HOVERGEN

Q60HE5; -.

Other

ProtoNet

Q60HE5.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Allosteric enzyme; FAD; Flavoprotein; NADP; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 656`	`656`		`Methylenetetrahydrofolate reductase.`	`PRO_0000190246`

Sequence information

Length: 656 AA [This is the length of the unprocessed precursor]

Molecular weight: 74656 Da [This is the MW of the unprocessed precursor]

CRC64: AFF7FA239B9520FB [This is a checksum on the sequence]

        10         20         30         40         50         60 
MVNEARGNDS LNPCLEGSAS SSSESSKDSS RCSTPGLDPE RHERLRDKMR RRMESGDKWF 

        70         80         90        100        110        120 
SLEFFPPRTA EGAVNLISRF DRMAAGGPLF IDVTWHPAGD PGSDKETSSM MIASTAVNYC 

       130        140        150        160        170        180 
GLETILHMTC CCQRLEEITG HLHKAKQLGL KNIMALRGDP IGDQWEEEEG GFNYAVDLVK 

       190        200        210        220        230        240 
HIRSEFGDYF DLCVAGYPKG HPEAGSFEAD LKHLKEKVSA GADFIITQLF FEADTFFRFV 

       250        260        270        280        290        300 
KACTDMGITC PIVPGIFPIQ GYHSLRQLVK QSKLEVPQEI KDVIEPIKDN DAAIRNYGIE 

       310        320        330        340        350        360 
LAVSLCHELL ASGLVPGLHF YTLNREMATT EVLKRLGMWT EDPRRPLPWA LSAHPKRREE 

       370        380        390        400        410        420 
DVRPIFWASR PKSYIYRTQE WDEFPNGRWG NSSSPAFGEL KDYYLFYLKS KSPRELLLKM 

       430        440        450        460        470        480 
WGEELTSEES VFEVFVLYLS GEPNRNGHKV TCLPWNDEPL AAETSLLKEE LLRVNRQGIL 

       490        500        510        520        530        540 
TINSQPNING KPSSDPVVGW GPSGGYVFQK AYLEFFTSRE TAEALLQVLK KYELRVNYHL 

       550        560        570        580        590        600 
VNVKGENITN APELQPNAVT WGIFPGREII QPTVVDPISF MFWKDEAFAL WIEQWGKLYE 

       610        620        630        640        650 
EESPSRTIIQ YIHDNYFLVN LVDNDFPLDN CLWQVVEDAL ELLNRPTQNE REMEAP

Q60HE5 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools