[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. TISSUE=Temporal cortex; Kusuda J., Osada N., Tanuma R., Hirata M., Sugano S., Hashimoto K.; "Isolation and characterization of cDNA for macaque neurological disease genes."; Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.

Comments

CATALYTIC ACTIVITY: Acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor.
COFACTOR: FAD (By similarity).
PATHWAY: Lipid metabolism; mitochondrial fatty acid beta-oxidation .
SUBUNIT: Homotetramer (By similarity).
SUBCELLULAR LOCATION: Mitochondrion matrix (By similarity).
MISCELLANEOUS: A number of straight-chain acyl-CoA dehydrogenases of different substrate specificities are present in mammalian tissues.
SIMILARITY: Belongs to the acyl-CoA dehydrogenase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AB125147; BAD51935.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

ModBase

Q60HI0.

Ontologies

GO:0005759;	Cellular component: mitochondrial matrix (inferred from electronic annotation from UniProtKB-SubCell).
QuickGo view.

Family and domain databases

InterPro

IPR006091; Acyl-CoA_DHase/Oxase_M.
IPR006089; Acyl-CoA_DHase_CS.
IPR006092; Acyl-CoA_DHase_N.
IPR006090; Acyl-CoA_Oxase/DHase_1.
IPR013786; AcylCoA_DH/ox_N.
IPR013764; AcylCoA_oxidase/DH_1/2_C.
Graphical view of domain structure.

Gene3D

G3DSA:2.40.110.10; Acyl_CoA_DH/ox_M; 1.
G3DSA:1.10.540.10; AcylCoA_DH/ox_N; 1.
G3DSA:1.20.140.10; AcylCoA_DH_1/2_C; 1.

Pfam

PF00441; Acyl-CoA_dh_1; 1.
PF02770; Acyl-CoA_dh_M; 1.
PF02771; Acyl-CoA_dh_N; 1.
Pfam graphical view of domain structure.

PROSITE

PS00072; ACYL_COA_DH_1; 1.
PS00073; ACYL_COA_DH_2; 1.

BLOCKS

Q60HI0.

Phylogenomic databases

HOVERGEN

Q60HI0; -.

Other

ProtoNet

Q60HI0.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

FAD; Fatty acid metabolism; Flavoprotein; Lipid metabolism; Mitochondrion; Oxidoreductase; Transit peptide.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`TRANSIT`	`1 30`	`30`	`Mitochondrion (By similarity).`
`CHAIN`	`31 430`	`400`	`Long-chain specific acyl-CoA dehydrogenase, mitochondrial.`	`PRO_0000000510`

Sequence information

Length: 430 AA [This is the length of the unprocessed precursor]

Molecular weight: 47838 Da [This is the MW of the unprocessed precursor]

CRC64: 0EA455DD1CF1EC29 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MAARLLRGSL RFLGGHCAAR PLPALRCSHS GGEERLETPS AKNLTDIGIR RIFSSEHDIF 

        70         80         90        100        110        120 
RKSIRKFFQE EVIPHHSEWE KAGEVSREVW EKAGKQGLLG VNIAEHLGGI GGDLYYAAVV 

       130        140        150        160        170        180 
WEEQAYSNCS GPGFSVHSGI VMSYITNYGS EEQIKHFIPQ MTAGKCIGAI AMTELGAGSD 

       190        200        210        220        230        240 
LQGIKTNAKK DGSDWILNGS KVFISNGWLS DVVIVVAVTN HEAPSPARGI SLFLVENGMK 

       250        260        270        280        290        300 
GFIKGRKLHK MGLKAQDTAE LFFEDVRLPA SALLGEENKG FYYIMKELPQ ERLLIADMAV 

       310        320        330        340        350        360 
SASEFMFEET RNYVKQRKAF GKTVAHLQTV QHKLAELKTH ICVTRAFVDN CLQLHEAKRL 

       370        380        390        400        410        420 
DSATACMAKY WASELQNSVA YDCVQLHGGW GYMWEYPIAK AYVDARVQPI YGGTNEIMKE 

       430 
LIAREIVFDK

Q60HI0 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools