ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!
Search for

UniProtKB/Swiss-Prot entry Q61790

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

Note: most headings are clickable, even if they don't appear as links. They link to the user manual or other documents.
Entry information
Entry name LAG3_MOUSE
Primary accession number Q61790
Secondary accession number Q0VBL2
Integrated into Swiss-Prot on November 1, 1997
Sequence was last modified on November 1, 1996 (Sequence version 1)
Annotations were last modified on    June 16, 2009 (Entry version 75)
Name and origin of the protein
Protein name Lymphocyte activation gene 3 protein [Precursor]
Synonyms LAG-3
CD223 antigen
Gene name
Name: Lag3
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=BALB/c;
TISSUE=Thymus;
DOI=10.1006/abio.1996.0382; PubMed=8921170 [NCBI, ExPASy, EBI, Israel, Japan]
Mastrangeli R., Micangeli E., Donini S.;
"Cloning of murine LAG-3 by magnetic bead bound homologous probes and PCR (gene-capture PCR).";
Anal. Biochem. 241:93-102(1996).
[2]
 NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=BALB/c;
TISSUE=Thymus;
DOI=10.1126/science.272.5260.405; PubMed=8602528 [NCBI, ExPASy, EBI, Israel, Japan]
Miyazaki T., Dierich A., Benoist C., Mathis D.;
"Independent modes of natural killing distinguished in mice lacking Lag3.";
Science 272:405-408(1996).
[3]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X98113; CAA66794.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC120591; AAI20592.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00125089; -.
RefSeq NP_032505.1; -.
UniGene Mm.4528
3D structure databases
ModBase Q61790.
Organism-specific databases
MGI MGI:106588; Lag3.
Gene expression databases
ArrayExpress Q61790; -.
Bgee Q61790; -.
CleanEx MM_LAG3; -.
GermOnline ENSMUSG00000030124; Mus musculus.
Ontologies
GO
GO:0009897; Cellular component: external side of plasma membrane (inferred from direct assay from MGI).
GO:0016021; Cellular component: integral to membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0042289; Molecular function: MHC class II protein binding (inferred from direct assay from MGI).
GO:0004888; Molecular function: transmembrane receptor activity (inferred from direct assay from MGI).
GO:0007166; Biological process: cell surface receptor linked signal transduction (inferred from direct assay from MGI).
GO:0045085; Biological process: negative regulation of interleukin-2 biosynthetic process (inferred from direct assay from MGI).
GO:0050868; Biological process: negative regulation of T cell activation (inferred from direct assay from MGI).
GO:0045954; Biological process: positive regulation of natural killer cell mediated cytotoxicity (inferred from direct assay from MGI).
QuickGo view.
Family and domain databases
InterPro IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR003599; Ig_sub.
IPR013106; Ig_V-set.
IPR015621; IL1-receptor.
Graphical view of domain structure.
Gene3D G3DSA:2.60.40.10; Ig-like_fold; 2.
PANTHER PTHR11890; IL1-receptor; 1.
Pfam PF07686; V-set; 2.
Pfam graphical view of domain structure.
SMART SM00409; IG; 3.
SMART graphical view of domain structure.
PROSITE PS50835; IG_LIKE; 2.
PROSITE graphical view of domain structure (profiles).
Proteomic databases
PRIDE Q61790; -.
Genome annotation databases
Ensembl ENSMUSG00000030124; Mus musculus. [Contig view]
GeneID 16768; -.
KEGG mmu:16768; -.
Phylogenomic databases
HOGENOM Q61790; -.
HOVERGEN Q61790; -.
OMA Q61790; AGDNGNF.
Other
NextBio 290590; -.
PMAP-CutDB Q61790; -.
SOURCE Lag3; Mus musculus.
ProtoNet Q61790.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane; Repeat; Signal; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    22  22     Potential. 
CHAIN   23   521  499     Lymphocyte activation gene 3 protein. PRO_0000014632
TOPO_DOM   23   442  420     Extracellular (Potential). 
TRANSMEM   443   463  21     Potential. 
TOPO_DOM   464   521  58     Cytoplasmic (Potential). 
DOMAIN   37   163  127     Ig-like V-type. 
DOMAIN   165   246  82     Ig-like C2-type 1. 
DOMAIN   258   341  84     Ig-like C2-type 2. 
DOMAIN   345   412  68     Ig-like C2-type 3. 
REGION   493   518  26     13 X 2 AA tandem repeats of E-X. 
CARBOHYD   184   184        N-linked (GlcNAc...) (Potential). 
CARBOHYD   244   244        N-linked (GlcNAc...) (Potential). 
CARBOHYD   309   309        N-linked (GlcNAc...) (Potential). 
CARBOHYD   337   337        N-linked (GlcNAc...) (Potential). 
CARBOHYD   381   381        N-linked (GlcNAc...) (Potential). 
DISULFID   44   156        Potential. 
DISULFID   185   235        Potential. 
DISULFID   276   327        Potential. 
DISULFID   363   405        Potential. 
Sequence information
Length: 521 AA [This is the length of the unprocessed precursor] Molecular weight: 56978 Da [This is the MW of the unprocessed precursor] CRC64: 64C29C40EB780E48 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MREDLLLGFL LLGLLWEAPV VSSGPGKELP VVWAQEGAPV HLPCSLKSPN LDPNFLRRGG 

        70         80         90        100        110        120 
VIWQHQPDSG QPTPIPALDL HQGMPSPRQP APGRYTVLSV APGGLRSGRQ PLHPHVQLEE 

       130        140        150        160        170        180 
RGLQRGDFSL WLRPALRTDA GEYHATVRLP NRALSCSLRL RVGQASMIAS PSGVLKLSDW 

       190        200        210        220        230        240 
VLLNCSFSRP DRPVSVHWFQ GQNRVPVYNS PRHFLAETFL LLPQVSPLDS GTWGCVLTYR 

       250        260        270        280        290        300 
DGFNVSITYN LKVLGLEPVA PLTVYAAEGS RVELPCHLPP GVGTPSLLIA KWTPPGGGPE 

       310        320        330        340        350        360 
LPVAGKSGNF TLHLEAVGLA QAGTYTCSIH LQGQQLNATV TLAVITVTPK SFGLPGSRGK 

       370        380        390        400        410        420 
LLCEVTPASG KERFVWRPLN NLSRSCPGPV LEIQEARLLA ERWQCQLYEG QRLLGATVYA 

       430        440        450        460        470        480 
AESSSGAHSA RRISGDLKGG HLVLVLILGA LSLFLLVAGA FGFHWWRKQL LLRRFSALEH 

       490        500        510        520 
GIQPFPAQRK IEELERELET EMGQEPEPEP EPQLEPEPRQ L
Q61790 in FASTA format

View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

BLAST logo BLAST submission on ExPASy/SIB
or at NCBI (USA) 		Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Hosted by ca flag CBR Canada Mirror sites: Australia Brazil China Korea Switzerland
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!