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UniProtKB/Swiss-Prot entry Q61941

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name NNTM_MOUSE
Primary accession number Q61941
Secondary accession number Q9JK70
Integrated into Swiss-Prot on May 30, 2000
Sequence was last modified on August 16, 2004 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 70)
Name and origin of the protein
Protein name NAD(P) transhydrogenase, mitochondrial [Precursor]
Synonyms EC 1.6.1.2
Nicotinamide nucleotide transhydrogenase
Pyridine nucleotide transhydrogenase
Gene name
Name: Nnt
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=C57BL/6 X CBA;
TISSUE=Liver;
DOI=10.1016/0005-2728(95)00159-X; PubMed=8616157 [NCBI, ExPASy, EBI, Israel, Japan]
Lagberg E.M., Betsholtz C., Rydstrom J.;
"The cDNA sequence of proton-pumping nicotinamide nucleotide transhydrogenase from man and mouse.";
Biochim. Biophys. Acta 1273:203-205(1996).
[2]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=129/SvJ;
DOI=10.1016/S0167-4781(01)00257-3; PubMed=11513952 [NCBI, ExPASy, EBI, Israel, Japan]
Arkblad E.L., Betsholtz C., Mandoli D., Rydstrom J.;
"Characterization of a nicotinamide nucleotide transhydrogenase gene from the green alga Acetabularia acetabulum and comparison of its structure with those of the corresponding genes in mouse and Caenorhabditis elegans.";
Biochim. Biophys. Acta 1520:115-123(2001).
[3]
 PROTEIN SEQUENCE OF 72-84; 214-224; 268-279; 367-379; 434-442; 769-777 AND 940-949, AND MASS SPECTROMETRY.
STRAIN=C57BL/6;
TISSUE=Brain;
Lubec G., Kang S.U.;
Submitted (APR-2007) to UniProtKB.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
Z49204; CAA89065.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF257157; AAF72982.2; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF257137; AAF72982.2; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF257138; AAF72982.2; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF257139; AAF72982.2; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF257140; AAF72982.2; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF257141; AAF72982.2; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF257142; AAF72982.2; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF257143; AAF72982.2; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF257144; AAF72982.2; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF257145; AAF72982.2; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF257146; AAF72982.2; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF257147; AAF72982.2; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF257148; AAF72982.2; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF257149; AAF72982.2; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF257150; AAF72982.2; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF257151; AAF72982.2; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF257152; AAF72982.2; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF257153; AAF72982.2; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF257154; AAF72982.2; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF257155; AAF72982.2; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF257156; AAF72982.2; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S54876; S54876.
UniGene Mm.195803
3D structure databases
HSSP Q13423; 1DJL. [HSSP ENTRY / PDB]
SMR Q61941; 902-1083.
ModBase Q61941.
PTM databases
PhosphoSite Q61941; -.
Organism-specific databases
MGI MGI:109279; Nnt.
Gene expression databases
CleanEx MM_NNT; -.
GermOnline ENSMUSG00000025453; Mus musculus.
Ontologies
GO
GO:0005743; Cellular component: mitochondrial inner membrane (inferred from direct assay from MGI).
QuickGo view.
Family and domain databases
InterPro IPR007698; Ala_DHase/PNT_C.
IPR008142; Ala_DHase/PNT_CS1.
IPR008143; Ala_DHase/PNT_CS2.
IPR007886; Ala_DHase/PNT_N.
IPR016040; NAD(P)-bd.
IPR004571; NADP_transhyd_a.
IPR004003; NADP_transhyd_b.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF01262; AlaDh_PNT_C; 1.
PF05222; AlaDh_PNT_N; 1.
PF02233; PNTB; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR00561; pntA; 1.
PROSITE PS00836; ALADH_PNT_1; 1.
PS00837; ALADH_PNT_2; 1.
BLOCKS Q61941.
Genome annotation databases
Ensembl ENSMUSG00000025453; Mus musculus. [Contig view]
Phylogenomic databases
HOVERGEN Q61941; -.
Other
SOURCE Nnt; Mus musculus.
ProtoNet Q61941.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Direct protein sequencing; Membrane; Mitochondrion; Mitochondrion inner membrane; NAD; NADP; Oxidoreductase; Transit peptide; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
TRANSIT   1     43  43     Mitochondrion (By similarity). 
CHAIN   44   1086  1043     NAD(P) transhydrogenase, mitochondrial. PRO_0000001056
TOPO_DOM   44    474  431     Mitochondrial matrix. 
TRANSMEM   475    493  19     Potential. 
TRANSMEM   501    521  21     Potential. 
TRANSMEM   527    546  20     Potential. 
TRANSMEM   558    578  21     Potential. 
TOPO_DOM   579    595  17     Mitochondrial matrix. 
TRANSMEM   596    616  21     Potential. 
TRANSMEM   622    642  21     Potential. 
TRANSMEM   646    666  21     Potential. 
TRANSMEM   672    691  20     Potential. 
TRANSMEM   702    722  21     Potential. 
TOPO_DOM   723    739  17     Cytoplasmic. 
TRANSMEM   740    760  21     Potential. 
TRANSMEM   778    797  20     Potential. 
TRANSMEM   801    819  19     Potential. 
TRANSMEM   833    853  21     Potential. 
TRANSMEM   857    879  23     Potential. 
TOPO_DOM   880   1086  207     Mitochondrial matrix. 
NP_BIND   229    259  31     NAD (By similarity). 
CONFLICT   35     35        T -> M (in Ref. 1; CAA89065). 
CONFLICT   775    775        P -> L (in Ref. 1; CAA89065). 
CONFLICT   813    813        G -> A (in Ref. 1; CAA89065). 
Sequence information
Length: 1086 AA [This is the length of the unprocessed precursor] Molecular weight: 113838 Da [This is the MW of the unprocessed precursor] CRC64: A023285169834D07 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MAHLLKTVVA GCSCPFLSNL GSSKVLPGKR DFVRTLRTHQ ALWCKSPVKP GIPYKQLTVG 

        70         80         90        100        110        120 
VPKEIFQNEK RVALSPAGVQ ALVKQGFNVV VESGAGEASK FPDDLYRAAG AQIQGMKEVL 

       130        140        150        160        170        180 
ASDLVVKVRA PMVNPTLGAH EADFLKPSGT LISFIYPAQN PDLLNKLSER KTTVLAMDQV 

       190        200        210        220        230        240 
PRVTIAQGYD ALSSMANISG YKAVVLAANH FGRFFTGQIT AAGKVPPAKI LIVGGGVAGL 

       250        260        270        280        290        300 
ASAGAAKSMG AVVRGFDTRA AALEQFKSLG AEPLEVDLKE SGEGQGGYAK EMSKEFIEAE 

       310        320        330        340        350        360 
MKLFAQQCKE VDILISTALI PGKKAPVLFS KEMIESMKEG SVVVDLAAEA GGNFETTKPG 

       370        380        390        400        410        420 
ELYVHKGITH IGYTDLPSRM ATQASTLYSN NITKLLKAIS PDKDNFHFEV KDDFDFGTMS 

       430        440        450        460        470        480 
HVIRGTVVMK DGKVIFPAPT PKNIPEEAPV KPKTVAELEA EKAGTVSMYT KTLTTASVYS 

       490        500        510        520        530        540 
AGLTGMLGLG IVAPNVAFSQ MVTTFGLAGI IGYHTVWGVT PALHSPLMSV TNAISGLTAV 

       550        560        570        580        590        600 
GGLALMGGHF YPSTTSQSLA ALATFISSVN IAGGFLVTQR MLDMFKRPTD PPEYNYLYLL 

       610        620        630        640        650        660 
PGGTFVGGYL AALYGGYNIE EIMYLGSGLC CVGALGGLST QGTARLGNAL GMIGVAGGLA 

       670        680        690        700        710        720 
ATLGGLKPDP QLLAQMSGAM AMGGTIGLTI AKRIQISDLP QLVAAFHSLV GLAAVLTCMA 

       730        740        750        760        770        780 
EYIVEYPHFA MDATSNFTKI VAYLGTYIGG VTFSGSLVAY GKLQGILKSA PLLLPGRHAL 

       790        800        810        820        830        840 
NAGLLAASVG GIIPFMADPS FTTGITCLGS VSGLSTLMGV TLTAAIGGAD MPVVITVLNS 

       850        860        870        880        890        900 
YSGWALCAEG FLLNNNLLTI VGALIGSSGA ILSYIMCVAM NRSLANVILG GYGTTSTAGG 

       910        920        930        940        950        960 
KPMEISGTHT EINLDNAVEM IREANSIVIT PGYGLCAAKA QYPIADLVKM LTEQGKKVRF 

       970        980        990       1000       1010       1020 
GIHPVAGRMP GQLNVLLAEA GVPYDIVLEM DEINSDFPDT DLVLVIGAND TVNSAAQEDP 

      1030       1040       1050       1060       1070       1080 
NSIIAGMPVL EVWKSKQVIV MKRSLGVGYA AVDNPIFYKP NTAMLLGDAK KTCDALQAKV 


RESYQK
Q61941 in FASTA format

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View entry in raw text format (no links)
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