[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. STRAIN=FVB/N; TISSUE=Mammary tumor; DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan] The MGC Project Team; "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."; Genome Res. 14:2121-2127(2004).
[2]	NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 19-40. PubMed=7792602 [NCBI, ExPASy, EBI, Israel, Japan] Cases O., Seif I., Grimsby J., Gaspar P., Chen K., Pournin S., Mueller U., Aguet M., Babinet C., Shih J.C., de Maeyer E.; "Aggressive behavior and altered amounts of brain serotonin and norepinephrine in mice lacking MAOA."; Science 268:1763-1766(1995).
[3]	PROTEIN SEQUENCE OF 137-147; 207-217; 268-280 AND 380-395, AND MASS SPECTROMETRY. STRAIN=C57BL/6; TISSUE=Brain; Lubec G., Kang S.U.; Submitted (APR-2007) to UniProtKB.

Comments

FUNCTION: Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine (By similarity).
CATALYTIC ACTIVITY: RCH₂NHR' + H₂O + O₂ = RCHO + R'NH₂ + H₂O₂.
COFACTOR: FAD.
SUBUNIT: Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer (By similarity).
SUBCELLULAR LOCATION: Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side.
SIMILARITY: Belongs to the flavin monoamine oxidase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

BC029100; AAH29100.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
S78615; AAB34677.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
S78606; AAB34677.1; JOINED; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

UniGene

Mm.21108

3D structure databases

SMR

Q64133; 23-509.

ModBase

Q64133.

Protein-protein interaction databases

IntAct

Q64133; -.

Organism-specific databases

MGI

MGI:96915; Maoa.

Gene expression databases

ArrayExpress

Q64133; -.

CleanEx

MM_MAOA; -.

GermOnline

ENSMUSG00000025037; Mus musculus.

Ontologies

GO:0005739;	Cellular component: mitochondrion (inferred from direct assay from MGI).
GO:0042420;	Biological process: dopamine catabolic process (inferred from direct assay from MGI).
QuickGo view.

Family and domain databases

InterPro

IPR001613; Amineoxid_fl.
IPR002937; Amino_oxidase.
Graphical view of domain structure.

Pfam

PF01593; Amino_oxidase; 1.
Pfam graphical view of domain structure.

PRINTS

PR00757; AMINEOXDASEF.

BLOCKS

Q64133.

Genome annotation databases

Ensembl

ENSMUSG00000025037; Mus musculus. [Contig view]

Phylogenomic databases

HOGENOM

Q64133; -.

HOVERGEN

Q64133; -.

Other

Maoa; Mus musculus.

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Catecholamine metabolism; Direct protein sequencing; FAD; Flavoprotein; Membrane; Mitochondrion; Mitochondrion outer membrane; Neurotransmitter degradation; Oxidoreductase; Transmembrane.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 526`	`526`	`Amine oxidase [flavin-containing] A.`	`PRO_0000099851`
`TOPO_DOM`	`1 497`	`497`	`Cytoplasmic (Potential).`
`TRANSMEM`	`498 518`	`21`	`Anchor for type IV membrane protein (Potential).`
`TOPO_DOM`	`519 526`	`8`	`Mitochondrial intermembrane (Potential).`
`SITE`	`335 335`	`1`	`Important for substrate specificity (By similarity).`
`SITE`	`374 374`	`1`	`Important for catalytic activity (By similarity).`
`MOD_RES`	`406 406`		`S-8alpha-FAD cysteine (By similarity).`

Sequence information

Length: 526 AA [This is the length of the unprocessed precursor]

Molecular weight: 59588 Da [This is the MW of the unprocessed precursor]

CRC64: 47FACA3581758217 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MTDLEKPSIT GHMFDVVVIG GGISGLAAAK LLSEYKINVL VLEARDRVGG RTYTVRNEHV 

        70         80         90        100        110        120 
KWVDVGGAYV GPTQNRILRL SKDLGIETYK VNVNERLVQY VKGKTYPFRG AFPPVWNPLA 

       130        140        150        160        170        180 
YLDYNNLWRT MDDMGKEIPV DAPWQARHAE EWDKITMKDL IDKICWTKTA REFAYLFVNI 

       190        200        210        220        230        240 
NVTSEPHEVS ALWFLWYVRQ CGGTSRIFSV TNGGQERKFV GGSGQISEQI MVLLGDKVKL 

       250        260        270        280        290        300 
SSPVTYIDQT DDNIIIETLN HEHYECKYVI SAIPPVLTAK IHFKPELPPE RNQLIQRLPM 

       310        320        330        340        350        360 
GAVIKCMVYY KEAFWKKKDY CGCMIIEDEE APISITLDDT KPDGSMPAIM GFILARKAER 

       370        380        390        400        410        420 
LAKLHKDIRK RKICELYAKV LGSQEALSPV HYEEKNWCEE QYSGGCYTAY FPPGIMTLYG 

       430        440        450        460        470        480 
RVIRQPVGRI YFAGTETATQ WSGYMEGAVE AGERAAREVL NALGKVAKKD IWVQEPESKD 

       490        500        510        520 
VPALEITHTF LERNLPSVPG LLKITGFSTS VALLCFVLYK FKQPQS

Q64133 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools