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UniProtKB/Swiss-Prot entry Q64HZ8

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DHE4_PANTR
Primary accession number Q64HZ8
Secondary accession numbers None
Integrated into Swiss-Prot on November 23, 2004
Sequence was last modified on October 25, 2004 (Sequence version 1)
Annotations were last modified on    September 2, 2008 (Entry version 32)
Name and origin of the protein
Protein name Glutamate dehydrogenase 2, mitochondrial [Precursor]
Synonyms GDH
EC 1.4.1.3
Gene name
Name: GLUD2
From
Pan troglodytes (Chimpanzee) [TaxID: 9598] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1038/ng1431; PubMed=15378063 [NCBI, ExPASy, EBI, Israel, Japan]
Burki F., Kaessmann H.;
"Birth and adaptive evolution of a hominoid gene that supports high neurotransmitter flux.";
Nat. Genet. 36:1061-1063(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AY588274; AAU03136.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_001009004.1; -.
3D structure databases
SMR Q64HZ8; 58-558.
ModBase Q64HZ8.
Ontologies
GO
GO:0005759; Cellular component: mitochondrial matrix (inferred from electronic annotation from UniProtKB-SubCell).
QuickGo view.
Family and domain databases
InterPro IPR006095; Glu/Leu/Phe/Val_DHase.
IPR006096; Glu/Leu/Phe/Val_DHase_C.
IPR006097; Glu/Leu/Phe/Val_DHase_dimer.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
PANTHER PTHR11606:SF2; GLFV_DH; 1.
Pfam PF00208; ELFV_dehydrog; 1.
PF02812; ELFV_dehydrog_N; 1.
Pfam graphical view of domain structure.
PRINTS PR00082; GLFDHDRGNASE.
PROSITE PS00074; GLFV_DEHYDROGENASE; 1.
BLOCKS Q64HZ8.
Genome annotation databases
Ensembl ENSPTRG00000028207; Pan troglodytes. [Contig view]
GeneID 449581; -.
KEGG ptr:449581; -.
Phylogenomic databases
HOVERGEN Q64HZ8; -.
Other
ProtoNet Q64HZ8.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Mitochondrion; NADP; Oxidoreductase; Transit peptide.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
TRANSIT   1    53  53     Mitochondrion (By similarity). 
CHAIN   54   558  505     Glutamate dehydrogenase 2, mitochondrial. PRO_0000007210
ACT_SITE   183   183        By similarity. 
BINDING   84    84        Substrate (By similarity). 
Sequence information
Length: 558 AA [This is the length of the unprocessed precursor] Molecular weight: 61439 Da [This is the MW of the unprocessed precursor] CRC64: 9180BC7CB62C251D [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MYRYLAKALL TSRAGPAALG SAANHSAALL GRGPGQPAAA SQPGLALAAR RHYSELVADR 

        70         80         90        100        110        120 
EDDPNFFKMV EGFFDRGASI VEDKLVKDLR TQESEEQKRN RVRGILRIIK PCNHVLSLSF 

       130        140        150        160        170        180 
PIRRDDGSWE VIEGYRAQHS QHRTPCKGGI RYSTDVSVDE VKALASLMTY KCAVVDVPFG 

       190        200        210        220        230        240 
GAKAGVKINP KNYTENELEK ITRRFTMELA KKGFIGPGVD VPAPDMNTGE REMSWIADTY 

       250        260        270        280        290        300 
ASTIGHYDIN AHACVTGKPI SQGGIHGRIS ATGRGVFHGI ENFINEASYM SILGMTPGFR 

       310        320        330        340        350        360 
DKTFVVQGFG NVGLHSMRYL HRFGAKCIAV GESDGSIWNP DGIDPKELED FRLQHGSLLG 

       370        380        390        400        410        420 
FPKAKPYEGS ILEIDCDILI PAATEKQLTK SNAPRVKAKI IAEGANGPTT PEADKIFLER 

       430        440        450        460        470        480 
NILVIPDLYL NAGGVTVSYF EWLKNLNHVS YGRLTFKYER DSNYHLLMSV QESLERKFGK 

       490        500        510        520        530        540 
HGGTIPIVPT AEFQDSISGA SEKDIVHSAL AYTMERSARQ IMHTAMKYNL GLDLRTAAYV 

       550 
NAIEKVFKVY SEAGVTFT
Q64HZ8 in FASTA format

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