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UniProtKB/Swiss-Prot entry Q64HZ9

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DHE4_HYLLA
Primary accession number Q64HZ9
Secondary accession numbers None
Integrated into Swiss-Prot on November 23, 2004
Sequence was last modified on October 25, 2004 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 28)
Name and origin of the protein
Protein name Glutamate dehydrogenase 2, mitochondrial [Precursor]
Synonyms GDH
EC 1.4.1.3
Gene name
Name: GLUD2
From
Hylobates lar (Common gibbon) [TaxID: 9580] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae; Hylobates.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1038/ng1431; PubMed=15378063 [NCBI, ExPASy, EBI, Israel, Japan]
Burki F., Kaessmann H.;
"Birth and adaptive evolution of a hominoid gene that supports high neurotransmitter flux.";
Nat. Genet. 36:1061-1063(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AY588269; AAU03135.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
3D structure databases
SMR Q64HZ9; 55-555.
ModBase Q64HZ9.
Ontologies
GO
GO:0005759; Cellular component: mitochondrial matrix (inferred from electronic annotation from UniProtKB-SubCell).
GO:0004353; Molecular function: glutamate dehydrogenase [NAD(P)+] activity (inferred from electronic annotation from EC).
QuickGo view.
Family and domain databases
InterPro IPR006095; Glu/Leu/Phe/Val_DHase.
IPR006096; Glu/Leu/Phe/Val_DHase_C.
IPR006097; Glu/Leu/Phe/Val_DHase_dimer.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
PANTHER PTHR11606:SF2; GLFV_DH; 1.
Pfam PF00208; ELFV_dehydrog; 1.
PF02812; ELFV_dehydrog_N; 1.
Pfam graphical view of domain structure.
PRINTS PR00082; GLFDHDRGNASE.
PROSITE PS00074; GLFV_DEHYDROGENASE; 1.
BLOCKS Q64HZ9.
Phylogenomic databases
HOVERGEN Q64HZ9; -.
Other
ProtoNet Q64HZ9.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Mitochondrion; NADP; Oxidoreductase; Transit peptide.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
TRANSIT   1    50  50     Mitochondrion (By similarity). 
CHAIN   51   555  505     Glutamate dehydrogenase 2, mitochondrial. PRO_0000007209
ACT_SITE   180   180        By similarity. 
BINDING   81    81        Substrate (By similarity). 
Sequence information
Length: 555 AA [This is the length of the unprocessed precursor] Molecular weight: 60866 Da [This is the MW of the unprocessed precursor] CRC64: 36BF0E321F993A53 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MYCYLGKALL PSGAGPAALG SAGAALLGRA RGQPAAAPQP GLALAAWRHY SEVVADRKDD 

        70         80         90        100        110        120 
PNFFKMVEGF FDRGASIVED KLVKDLRTRE SEEQKRNRVR GILRIIKPCN HVLSLSFPIR 

       130        140        150        160        170        180 
RDDGSWEVIE GYRAQHSQHR TPCKGGIRYS ADVSVDEVKA LASLMTYKCA VVDVPFGGAK 

       190        200        210        220        230        240 
AGVKINPKNY TENELEKITR RFTMELAKKG FIGPGIDVPA PDMNTGEREM SWIADTYAST 

       250        260        270        280        290        300 
IGHYDINAHA CVTGKPISQG GIHGRISATG RGVFHGIENF INEASYMSIL GMTPGFGDKT 

       310        320        330        340        350        360 
FVVQGFGNVG LHSMRYLHRF GAKCIAVGES DGSIWNPDGI DPKELEDFKL QHGSILGFPK 

       370        380        390        400        410        420 
AKPYEGSILE ADCDILIPAA SEKQLTKSNA PRVKAKIIAE GANGPTTPEA DKIFLERNIM 

       430        440        450        460        470        480 
VIPDLYVNAG GVTVSYFEWL KNLNHVSYGR LTFKYERDSN YHLLMSVQES LERKFGKHGG 

       490        500        510        520        530        540 
TIPIVPTAEF QDSISGASEK DIVHSALAYT MERSARQIMR TAMKYNLGLD LRTAAYVNAI 

       550 
EKVFKVYSEA GVTFT
Q64HZ9 in FASTA format

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