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UniProtKB/Swiss-Prot entry Q64RE7

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HISX_BACFR
Primary accession number Q64RE7
Secondary accession numbers None
Integrated into Swiss-Prot on December 7, 2004
Sequence was last modified on October 25, 2004 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 34)
Name and origin of the protein
Protein name Histidinol dehydrogenase
Synonyms HDH
EC 1.1.1.23
Gene name
Name: hisD
OrderedLocusNames: BF3189
From
Bacteroides fragilis [TaxID: 817] [HAMAP proteome]
Taxonomy Bacteria; Bacteroidetes; Bacteroidetes (class); Bacteroidales; Bacteroidaceae; Bacteroides.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=YCH46;
DOI=10.1073/pnas.0404172101; PubMed=15466707 [NCBI, ExPASy, EBI, Israel, Japan]
Kuwahara T., Yamashita A., Hirakawa H., Nakayama H., Toh H., Okada N., Kuhara S., Hattori M., Hayashi T., Ohnishi Y.;
"Genomic analysis of Bacteroides fragilis reveals extensive DNA inversions regulating cell surface adaptation.";
Proc. Natl. Acad. Sci. U.S.A. 101:14919-14924(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AP006841; BAD49934.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_100468.1; -.
3D structure databases
ModBase Q64RE7.
Enzyme and pathway databases
BioCyc BFRA295405:BF3189-MON; -.
Ontologies
GO
GO:0004399; Molecular function: histidinol dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0000105; Biological process: histidine biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_01024; -; 1.
PBIL [Tree]
InterPro IPR001692; Histidinol_DHase.
IPR012131; Hstdl_DHase_prok.
Graphical view of domain structure.
PANTHER PTHR21256:SF2; Hstdl_DH_prok; 1.
Pfam PF00815; Histidinol_dh; 1.
Pfam graphical view of domain structure.
PRINTS PR00083; HOLDHDRGNASE.
ProDom PD002680; Histidinol_dh; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR00069; hisD; 1.
PROSITE PS00611; HISOL_DEHYDROGENASE; 1.
BLOCKS Q64RE7.
Genome annotation databases
GeneID 3083091; -.
GenomeReviews AP006841_GR; BF3189.
KEGG bfr:BF3189; -.
NMPDR fig|295405.3.peg.3530; -.
Phylogenomic databases
HOGENOM Q64RE7; -.
Genome annotation databases
CMR Q64RE7; BF3189.
Other
ProtoNet Q64RE7.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Complete proteome; Histidine biosynthesis; Metal-binding; NAD; Oxidoreductase; Zinc.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   428  428     Histidinol dehydrogenase. PRO_0000135730
ACT_SITE   322   322        Proton acceptor (By similarity). 
ACT_SITE   323   323        Proton acceptor (By similarity). 
METAL   255   255        Zinc (By similarity). 
METAL   258   258        Zinc (By similarity). 
METAL   356   356        Zinc (By similarity). 
METAL   415   415        Zinc (By similarity). 
BINDING   124   124        NAD (By similarity). 
BINDING   186   186        NAD (By similarity). 
BINDING   209   209        NAD (By similarity). 
BINDING   233   233        Substrate (By similarity). 
BINDING   255   255        Substrate (By similarity). 
BINDING   258   258        Substrate (By similarity). 
BINDING   323   323        Substrate (By similarity). 
BINDING   356   356        Substrate (By similarity). 
BINDING   410   410        Substrate (By similarity). 
BINDING   415   415        Substrate (By similarity). 
Sequence information
Length: 428 AA [This is the length of the unprocessed precursor] Molecular weight: 46530 Da [This is the MW of the unprocessed precursor] CRC64: BDFEB76D7C6BEB2A [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MKLIKYPDRS QWNEILKRPV LETENLFDTV RNIINRVRAG GDRVVMECEA VFDKAELTSL 

        70         80         90        100        110        120 
AVTSAEIEEA EKEVPIELKA AIYLAKRNIE TFHSAQRFEG KKVDTMEGVT CWQKAVAIEK 

       130        140        150        160        170        180 
VGLYIPGGTA PLFSTVLMLA IPAKIAGCKE IVLCTPPDKN GKVHPAILFA ARLAGVSKIF 

       190        200        210        220        230        240 
KVGGVQAIAA MAYGTESIPK VYKIFGPGNQ YVTAAKQLVS LRDVAIDMPA GPSEVEVLAD 

       250        260        270        280        290        300 
ESANPVFVAA DLLSQAEHGV DSQAMLVTTS EKLQTEVVYE VERQLGYLTR RDIAEKSLAN 

       310        320        330        340        350        360 
SKLILVKDME EALELTNAYA PEHLIIETKD YMEVAGQIVN AGSVFLGAFS PESAGDYASG 

       370        380        390        400        410        420 
TNHTLPTNGY AKAYSGVSLD SFIRKITFQE ILPSGMSAIG PAIEVMAANE HLDAHKNAVT 


VRLEEIRK
Q64RE7 in FASTA format

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