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[1]
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NUCLEOTIDE SEQUENCE [MRNA].
Jin D.-Y.,
Tie J.-K.,
Stafford D.W.;
"Bovine vitamin K epoxide reductase cDNA.";
Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
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[2]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=Hereford;
TISSUE=Fetal liver;
NIH - Mammalian Gene Collection (MGC) project;
Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
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- FUNCTION: Involved in vitamin K metabolism. Catalytic subunit of the vitamin K epoxide reductase (VKOR) complex which reduces inactive vitamin K 2,3-epoxide to active vitamin K (By similarity).
- CATALYTIC ACTIVITY: 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol = 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol.
- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity).
- MISCELLANEOUS: The location of two cysteine active-site residues within a proposed transmembrane is consistent both with the known hydrophobic environment of the thiol redox site of the enzyme and with the lipophilicity of vitamin K and warfarin (By similarity).
- SIMILARITY: Belongs to the VKOR family.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 163 AA [This is the length of the unprocessed precursor] |
Molecular weight: 17967 Da [This is the MW of the unprocessed precursor] |
CRC64: 7C8A7A5057908F20 [This is a checksum on the sequence] |
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10 20 30 40 50 60
MGATWRSPGW VRLALCLAGL VLSLYALHVK AARARDRDYR ALCDVGTAIS CSRVFSSRWG
70 80 90 100 110 120
RGFGLVEHVL GKDSILNQSN SIFGCIFYTL QLLLGCLQGR WASVLLRLSC LVSLAGSVYL
130 140 150 160
AWILFFVLYD FCIVCITTYA INVGLTVLSF REVQGPQGKV KGH
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Q6B4J2 in FASTA format |
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