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UniProtKB/Swiss-Prot entry Q6C5H4


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name GSHR_YARLI
Primary accession number Q6C5H4
Secondary accession numbers None
Integrated into Swiss-Prot on October 11, 2004
Sequence was last modified on August 16, 2004 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 31)
Name and origin of the protein
Protein name Glutathione reductase
Synonyms GRase
GR
EC 1.8.1.7
Gene name
Name: GLR1
OrderedLocusNames: YALI0E18029g
From
Yarrowia lipolytica (Candida lipolytica) [TaxID: 4952] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Dipodascaceae; Yarrowia.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=CLIB 122 / E 150;
DOI=10.1038/nature02579; PubMed=15229592 [NCBI, ExPASy, EBI, Israel, Japan]
Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S., Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L.;
"Genome evolution in yeasts.";
Nature 430:35-44(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CR382131; CAG79681.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq XP_504088.1; -.
3D structure databases
ModBase Q6C5H4.
Family and domain databases
InterPro IPR013027; FAD_pyr_nucl-diS_OxRdtase.
IPR006322; Glut_reduct_1.
IPR000815; Hg_reductase.
IPR001100; Pyr_nuc-diS_OxRdtase.
IPR004099; Pyr_nucl-diS_OxRdtase_dimer.
IPR012999; Pyr_OxRdtase_I_AS.
IPR001327; Pyr_OxRdtase_NAD_bd.
Graphical view of domain structure.
Gene3D G3DSA:3.30.390.30; Pyr_redox_dim; 1.
Pfam PF00070; Pyr_redox; 1.
PF07992; Pyr_redox_2; 1.
PF02852; Pyr_redox_dim; 1.
Pfam graphical view of domain structure.
PRINTS PR00368; FADPNR.
PR00945; HGRDTASE.
PR00411; PNDRDTASEI.
ProDom PD000139; FAD_pyr_redox; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR01421; gluta_reduc_1; 1.
PROSITE PS00076; PYRIDINE_REDOX_1; 1.
BLOCKS Q6C5H4.
Genome annotation databases
GeneID 2911696; -.
KEGG yli:YALI0E18029g; -.
Phylogenomic databases
HOGENOM Q6C5H4; -.
Other
ProtoNet Q6C5H4.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Cytoplasm; FAD; Flavoprotein; NADP; Oxidoreductase; Redox-active center.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   470  470     Glutathione reductase. PRO_0000067971
NP_BIND   36    44  9     FAD (By similarity). 
ACT_SITE   459   459        Proton acceptor (By similarity). 
DISULFID   44    49        Redox-active (By similarity). 
Sequence information
Length: 470 AA [This is the length of the unprocessed precursor] Molecular weight: 51302 Da [This is the MW of the unprocessed precursor] CRC64: B9E4760F181DD143 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MASIPHYDYL VIGGGSGGVA SARRAASYGA KTLLIEGKAL GGTCVNVGCV PKKVMWNASD 

        70         80         90        100        110        120 
LAGRIRQAKE YGFPDVDPKY ADNFDWSGFK AKRDAYVKRL NGIYERNLQK EGVEYVFGWA 

       130        140        150        160        170        180 
TLYKQEGQEF PLVHVKSDDG NTKLYSAKKI MIATGGKPRL PDVPGAEYGI DSDGFFALET 

       190        200        210        220        230        240 
QPKRVAVVGG GYIGVELAGV FHGLNSETTL FCRGQTVLRA FDIMIQDTIT DYYVKEGINV 

       250        260        270        280        290        300 
LKGSGVKKIV KKDNGELLVT YEQDGAEKDI TLDSLIWTIG REPLKDTLNL GEFGIKTNKR 

       310        320        330        340        350        360 
GYIEVDEYQR SSVDNIYSLG DVCGKVELTP MAIAAGRKLS NRLFGPTEFK NQKQDYTDVP 

       370        380        390        400        410        420 
SAVFSHPEVG SIGITEAAAK EQYGEENVKV YTSKFVAMYY AMLEEKAPTA YKLVCAGKDE 

       430        440        450        460        470 
KVVGLHIVGA DSAEILQGFG VAIRMGATKA DFDNVVAIHP TSAEELVTMR 

Q6C5H4 in FASTA format

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