ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!
Search for

UniProtKB/Swiss-Prot entry Q6CTX8


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

Note: most headings are clickable, even if they don't appear as links. They link to the user manual or other documents.
Entry information
Entry name PYRD2_KLULA
Primary accession number Q6CTX8
Secondary accession numbers None
Integrated into Swiss-Prot on September 27, 2004
Sequence was last modified on August 16, 2004 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 38)
Name and origin of the protein
Protein name Dihydroorotate dehydrogenase, mitochondrial [Precursor]
Synonyms DHOdehase
DHODase
DHOD
EC 1.3.3.1
Dihydroorotate oxidase
Gene name
Name: URA9
OrderedLocusNames: KLLA0C09240g
From
Kluyveromyces lactis (Yeast) (Candida sphaerica) [TaxID: 28985] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NRRL Y-1140 / WM37;
DOI=10.1038/nature02579; PubMed=15229592 [NCBI, ExPASy, EBI, Israel, Japan]
Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S., Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L.;
"Genome evolution in yeasts.";
Nature 430:35-44(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CR382123; CAH01462.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq XP_452611.1; -.
3D structure databases
ModBase Q6CTX8.
Ontologies
GO
GO:0005743; Cellular component: mitochondrial inner membrane (inferred from electronic annotation from UniProtKB-SubCell).
QuickGo view.
Family and domain databases
InterPro IPR013785; Aldolase_TIM.
IPR005719; DHO_DHase_2.
IPR001295; Dihydroorotate_DHase_core.
Graphical view of domain structure.
Gene3D G3DSA:3.20.20.70; Aldolase_TIM; 1.
Pfam PF01180; DHO_dh; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR01036; pyrD_sub2; 1.
PROSITE PS00911; DHODEHASE_1; 1.
PS00912; DHODEHASE_2; 1.
BLOCKS Q6CTX8.
Genome annotation databases
GeneID 2891871; -.
KEGG kla:KLLA0C09240g; -.
Phylogenomic databases
HOGENOM Q6CTX8; -.
Other
ProtoNet Q6CTX8.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; FAD; Flavoprotein; Membrane; Mitochondrion; Mitochondrion inner membrane; Oxidoreductase; Pyrimidine biosynthesis; Transit peptide.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
TRANSIT   1     ?        Mitochondrion (Potential). 
CHAIN   ?   445        Dihydroorotate dehydrogenase, mitochondrial. PRO_0000029893
ACT_SITE   254   254        Nucleophile (By similarity). 
Sequence information
Length: 445 AA [This is the length of the unprocessed precursor] Molecular weight: 48071 Da [This is the MW of the unprocessed precursor] CRC64: 74F746F6773A3492 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MNSGFPRILS KKLFTLNQSQ FFVKNGMVPL KAGISGPKLL KYTVGIAIGS FAGFYFSNSR 

        70         80         90        100        110        120 
SAFHEYVLCP MLRLVTPDAE DGHKLGIWFL KNGLAPRLWF DNDDKVLNVN IFGKKLTNPI 

       130        140        150        160        170        180 
GCAAGLDKNG DAIDGILSGG FGYIEIGSVT PLPQPGNPRP RFFRLPLDDA VINRYGFNSS 

       190        200        210        220        230        240 
GHDTVVNTLQ SRITSFINSY MFKDNSVENL SLYKDKLLGV NLGKNKTGDE VQDYLKGVES 

       250        260        270        280        290        300 
FQKYADVLVI NVSSPNTPGL RSLQKESILT DLLTQVVAKR DSLVTSGNAL GAKTHKPPVL 

       310        320        330        340        350        360 
VKVAPDLVEE EIKSIAEAAK KSKVDGIIIS NTTIQRPTTL ITEDSDLVSQ AGGLSGKPLK 

       370        380        390        400        410        420 
PLALKALKTM AKYTKGSGLV LVGCGGISSG ADAIEFAKAG ASMVELYTAY AYKGPGLIAK 

       430        440 
IKDETTELLK KENKTWSEII GEDIK 

Q6CTX8 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

BLAST logo BLAST submission on ExPASy/SIB
or at NCBI (USA)
Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
 Hosted by ca flag CBR Canada Mirror sites: Australia  Brazil  China  Korea  Switzerland
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!