|
|
|
|
|
|
[1]
|
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1073/pnas.0402521101; PubMed=15213324 [NCBI, ExPASy, EBI, Israel, Japan]
Holden M.T.G.,
Feil E.J.,
Lindsay J.A.,
Peacock S.J.,
Day N.P.J.,
Enright M.C.,
Foster T.J.,
Moore C.E.,
Hurst L.,
Atkin R.,
Barron A.,
Bason N.,
Bentley S.D.,
Chillingworth C.,
Chillingworth T.,
Churcher C.,
Clark L.,
Corton C.,
Cronin A., ![]()
Doggett J.,
Dowd L.,
Feltwell T.,
Hance Z.,
Harris B.,
Hauser H.,
Holroyd S.,
Jagels K.,
James K.D.,
Lennard N.,
Line A.,
Mayes R.,
Moule S.,
Mungall K.,
Ormond D.,
Quail M.A.,
Rabbinowitsch E.,
Rutherford K.M.,
Sanders M.,
Sharp S.,
Simmonds M.,
Stevens K.,
Whitehead S.,
Barrell B.G.,
Spratt B.G.,
Parkhill J.;
"Complete genomes of two clinical Staphylococcus aureus strains: evidence for the rapid evolution of virulence and drug resistance.";
Proc. Natl. Acad. Sci. U.S.A. 101:9786-9791(2004).
|
|
|
|
- FUNCTION: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).
- CATALYTIC ACTIVITY: Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.
- COFACTOR: Thiamine pyrophosphate (By similarity).
- SUBUNIT: Heterodimer of an alpha and a beta chain.
|
|
|
|
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Length: 370 AA [This is the length of the unprocessed precursor] |
Molecular weight: 41413 Da [This is the MW of the unprocessed precursor] |
CRC64: 5172134E6FE80EE0 [This is a checksum on the sequence] |
|
10 20 30 40 50 60
MAPKLQAQFD AVKVLNDTQS KFEMVQILDE NGNVVNEDLV PDLTDEQLVE LMERMVWTRI
70 80 90 100 110 120
LDQRSISLNR QGRLGFYAPT AGQEASQLAS QYALEKEDYI LPGYRDVPQI IWHGLPLTEA
130 140 150 160 170 180
FLFSRGHFKG NQFPEGVNAL SPQIIIGAQY IQTAGVAFAL KKRGKNAVAI TYTGDGGSSQ
190 200 210 220 230 240
GDFYEGINFA AAYKAPAIFV IQNNNYAIST PRSKQTAAET LAQKAIAVGI PGIQVDGMDA
250 260 270 280 290 300
LAVYQATKEA RDRAVAGEGP TLIETMTYRY GPHTMAGDDP TRYRTSDEDA EWEKKDPLVR
310 320 330 340 350 360
FRKFLENKGL WNEDKENEVI ERAKADIKAA IKEADNTEKQ TVTSLMEIMY EDMPQNLAEQ
370
YEIYKEKESK
|
Q6GHZ2 in FASTA format |
|
ExPASy Home page
CBR Canada