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[1]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3), GLYCOSYLATION, TISSUE SPECIFICITY, COFACTOR, AND SUBUNIT.
STRAIN=Wistar;
TISSUE=Seminal vesicle;
DOI=10.1074/jbc.M010933200; PubMed=11278790 [NCBI, ExPASy, EBI, Israel, Japan]
Benayoun B.,
Esnard-Feve A.,
Castella S.,
Courty Y.,
Esnard F.;
"Rat seminal vesicle FAD-dependent sulfhydryl oxidase: biochemical characterization and molecular cloning of a member of the new sulfhydryl oxidase/quiescin Q6 gene family.";
J. Biol. Chem. 276:13830-13837(2001).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), PROTEIN SEQUENCE OF 33-65, AND MASS SPECTROMETRY.
DOI=10.1016/S0923-1811(02)00061-0; PubMed=12354420 [NCBI, ExPASy, EBI, Israel, Japan]
Matsuba S.,
Suga Y.,
Ishidoh K.,
Hashimoto Y.,
Takamori K.,
Kominami E.,
Wilhelm B.,
Seitz J.,
Ogawa H.;
"Sulfhydryl oxidase (SOx) from mouse epidermis: molecular cloning, nucleotide sequence, and expression of recombinant protein in the cultured cells.";
J. Dermatol. Sci. 30:50-62(2002).
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[3]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, AND MASS SPECTROMETRY.
STRAIN=Wistar;
TISSUE=Brain;
DOI=10.1016/j.bbaexp.2006.04.008; PubMed=16806532 [NCBI, ExPASy, EBI, Israel, Japan]
Radom J.,
Colin D.,
Thiebault F.,
Dognin-Bergeret M.J.,
Mairet-Coello G.,
Esnard-Feve A.,
Fellmann D.,
Jouvenot M.;
"Identification and expression of a new splicing variant of FAD-sulfhydryl oxidase in adult rat brain.";
Biochim. Biophys. Acta 1759:225-233(2006).
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- FUNCTION: Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins.
- CATALYTIC ACTIVITY: 4 R'C(R)SH + O2 = 2 R'C(R)S-S(R)CR' + 2 H2O.
- COFACTOR: Binds 1 FAD per subunit.
- SUBUNIT: Monomer.
- SUBCELLULAR LOCATION: Isoform 1: Golgi apparatus membrane; Single-pass membrane protein (By similarity).
- SUBCELLULAR LOCATION: Isoform 2: Secreted (By similarity). Note=Found in the extracellular medium of quiescent cells but is not found in proliferating cells (By similarity).
- ALTERNATIVE PRODUCTS:
3 named isoforms [FASTA] produced by alternative splicing.
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| Name | 3 |
| Isoform ID | Q6IUU3-3 |
| Note: No experimental confirmation available. |
| Features which should be applied to build the isoform sequence: VSP_020497, VSP_020498. |
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- TISSUE SPECIFICITY: Isoform 1 is expressed in brain, hypophysis, heart, testis and the seminal vesicle. Isoform 3 is highly expressed in the seminal vesicles followed by testis, heart, brain, thymus, hypophysis and lung. Also expressed in prostate, kidney, spleen, liver.
- SIMILARITY: Belongs to the quiescin-sulfhydryl oxidase (QSOX) family.
- SIMILARITY: Contains 1 ERV/ALR sulfhydryl oxidase domain.
- SIMILARITY: Contains 1 thioredoxin domain.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 750 AA [This is the length of the unprocessed precursor] |
Molecular weight: 82412 Da [This is the MW of the unprocessed precursor] |
CRC64: 1781E657ED085114 [This is a checksum on the sequence] |
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10 20 30 40 50 60
MRRCGRHSGP PSLLLLLLLL PPLLLSVPGA YAARLSVLYS SSDPLTLLDA DTVRPAVLGS
70 80 90 100 110 120
SSAWAVEFFA SWCGHCIAFA PTWKELANDV KDWRPALNLA VLDCADETNS AVCREFNIAG
130 140 150 160 170 180
FPTVRFFKAF SKNGTGTALP AAGANVQTLR MRLIDALESH RDTWPPACPP LEPAKLKDIN
190 200 210 220 230 240
EFFTRSKAEY LALIFEREDS YLGREVTLDL SQFHAVAVRR VLNSESDVVS KFAVTDFPSC
250 260 270 280 290 300
YLLLRNGSVS RVPVLVESRP FYTSYLRGLP GLTREAPPTT AAPVTPDKIA PTVWKFADRS
310 320 330 340 350 360
KIYMADLESA LHYILRVEVG KFSVLEGQRL VALKKFVAVL AKYFPGQPLV QNFLHSINDW
370 380 390 400 410 420
LQKQQKKKIP YSYFKAALDS RKENAVLAEK VNWIGCQGSE PHFRGFPCSL WVLFHFLTVQ
430 440 450 460 470 480
AHRYSEAHPQ EPADGQEVLQ AMRSYVQSFF GCRDCANHFE QMAAASMHQV KSPSNAVLWL
490 500 510 520 530 540
WTSHNRVNAR LSGALSEDPQ FPKVQWPPRE LCSACHNEVN GQVPLWDLGA TLNFLKAHFS
550 560 570 580 590 600
PANIVRDPPA PGPASRRGTQ DPEASPNLVM DTLKLETGNS VLGHEQAASA ASPGATALDV
610 620 630 640 650 660
PAGKPEASGP QELNAGLSMG GASPGQGPPE HTEELLRDVQ ENAQGQQHLS KRDTEALLLP
670 680 690 700 710 720
EVNHLQGPLA PRRGGHSPKQ LASILEGEPE ALAIQGRRQW LQVLGGGVSF LDISLCVGLY
730 740 750
SVSFMGLLAM YTYFRARMRT PKGHVSYPTA
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Q6IUU3 in FASTA format |
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