NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=PG1;
DOI=10.1101/gr.1673304; PubMed=14762060 [NCBI, ExPASy, EBI, Israel, Japan]
Westberg J., Persson A., Holmberg A., Goesmann A., Lundeberg J., Johansson K.-E., Pettersson B., Uhlen M.;
"The genome sequence of Mycoplasma mycoides subsp. mycoides SC type strain PG1T, the causative agent of contagious bovine pleuropneumonia (CBPP).";
Genome Res. 14:221-227(2004).

Comments

FUNCTION: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity).
CATALYTIC ACTIVITY: Inosine 5'-phosphate + NH₃ + NADP⁺ = guanosine 5'-phosphate + NADPH.
SIMILARITY: Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

BX293980; CAE76703.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_975061.1; -.

3D structure databases

HSSP

P12268; 1B3O. [HSSP ENTRY / PDB]

ModBase

Q6MUI1.

Enzyme and pathway databases

BioCyc

MMYC272632:MSC_0050-MON; -.

Ontologies

GO:0003920;	Molecular function: GMP reductase activity (inferred from electronic annotation from HAMAP).
GO:0006163;	Biological process: purine nucleotide metabolic process (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_01511; -; 1.
PBIL [Tree]

InterPro

IPR013785; Aldolase_TIM.
IPR005994; GMP_reduct2.
IPR015875; IMP_DH/GMP_Rdtase_CS.
IPR001093; IMP_DHase_GMPRtase.
Graphical view of domain structure.

Gene3D

G3DSA:3.20.20.70; Aldolase_TIM; 1.

Pfam

PF00478; IMPDH; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF036500; GMP_red_Firmic; 1.

TIGRFAMs

TIGR01306; GMP_reduct_2; 1.

PROSITE

PS00487; IMP_DH_GMP_RED; FALSE_NEG.

BLOCKS

Q6MUI1.

Genome annotation databases

GeneID

2745129; -.

GenomeReviews

BX293980_GR; MSC_0050.

KEGG

mmy:MSC_0050; -.

Phylogenomic databases

HOGENOM

Q6MUI1; -.

Genome annotation databases

CMR

Q6MUI1; MSC_0050.

Other

ProtoNet

Q6MUI1.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; NADP; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 320`	`320`	`GMP reductase.`	`PRO_0000294278`
`NP_BIND`	`203 226`	`24`	`NADP (Potential).`
`ACT_SITE`	`174 174`		`Thioimidate intermediate (By similarity).`

Sequence information

Length: 320 AA [This is the length of the unprocessed precursor]

Molecular weight: 35962 Da [This is the MW of the unprocessed precursor]

CRC64: 3C96F2F3EDA24979 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MKIFDYDDVQ LIPEMCIVNS RKECETTATL GKHTFKLPVV PANMATIINE ELAEKLARND 

        70         80         90        100        110        120 
YFYIMHRFNV DQLKFIKNMK DKNLITSISL GVKPDEYKLV DQMVQQNLIP DYITIDIAHG 

       130        140        150        160        170        180 
HALSVKNMIS YIREKMKDQV FIIAGNVTTP KAVRDLELWG ADATKIEIGP GKVCITKLKT 

       190        200        210        220        230        240 
GFGTGGWQLS ALKYCAKTAS KPIIADGGLR VHGDIAKSIR MGASFCMIVS LFAAHLESPG 

       250        260        270        280        290        300 
KEVEINNCIY KEYYGSASEY NKSEKRYVEG KKELIKIRGS IFDTLKEMTE DLQSSISYAG 

       310        320 
GKDLQAIKRV DYVLLGDYKD

Q6MUI1 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools