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[1]
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NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, CATALYTIC ACTIVITY, ENZYME REGULATION, AND 3D-STRUCTURE MODELING.
TISSUE=Liver;
DOI=10.1016/j.cbpc.2004.10.002; PubMed=15621520 [NCBI, ExPASy, EBI, Israel, Japan]
Setini A.,
Pierucci F.,
Senatori O.,
Nicotra A.;
"Molecular characterization of monoamine oxidase in zebrafish (Danio rerio).";
Comp. Biochem. Physiol. 140B:153-161(2005).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, CATALYTIC ACTIVITY, ENZYME REGULATION, AND TISSUE SPECIFICITY.
TISSUE=Brain;
DOI=10.1002/cne.21057; PubMed=16917825 [NCBI, ExPASy, EBI, Israel, Japan]
Anichtchik O.,
Sallinen V.,
Peitsaro N.,
Panula P.;
"Distinct structure and activity of monoamine oxidase in the brain of zebrafish (Danio rerio).";
J. Comp. Neurol. 498:593-610(2006).
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[3]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Kidney;
NIH - Zebrafish Gene Collection (ZGC) project;
Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
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- FUNCTION: Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. Oxidizes both 5-hydroxytryptamine (5-HT) and beta-phenylethylamine (PEA).
- CATALYTIC ACTIVITY: RCH2NH2 + H2O + O2 = RCHO + NH3 + H2O2.
- COFACTOR: FAD.
- ENZYME REGULATION: Inhibited by both clorgyline (selective MAOA inhibitor) and deprenyl (selective MAOB inhibitor).
- SUBUNIT: Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer (By similarity).
- SUBCELLULAR LOCATION: Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side.
- TISSUE SPECIFICITY: Strongest expression in brain and intestine, followed by liver, heart and gill. Little expression in spleen, eye or muscle. In brain, highest activity in noradrenergic and serotonergic cell groups and those of the habenulointerpeduncular pathway; moderate levels in dopaminergic cell clusters.
- MISCELLANEOUS: There appears to be only one form of this enzyme in zebrafish, whereas in mammals two forms (MAOA and MAOB) exist.
- SIMILARITY: Belongs to the flavin monoamine oxidase family.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 522 AA [This is the length of the unprocessed precursor] |
Molecular weight: 58765 Da [This is the MW of the unprocessed precursor] |
CRC64: 8FC58B2A13BFE15C [This is a checksum on the sequence] |
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10 20 30 40 50 60
MTANAYDVIV IGGGISGLSA AKLLVDSGLN PVVLEARSRV GGRTYTVQNK ETKWVDLGGA
70 80 90 100 110 120
YIGPTQNRIL RIAKQYGVKT YKVNEEESLV HYVKGKSYPF KGPFPPMWNP FAYMDYNNLW
130 140 150 160 170 180
RTMDKMGMEI PKEAPWRAPH AEEWDKMTMQ QLFDKICWTR SARRFATLFV NVNVTSEPHE
190 200 210 220 230 240
VSALWFLWYV KQCGGTMRIF STTNGGQERK FAGGANQISE GMARELGDRV KLSRAVCSID
250 260 270 280 290 300
QTGDLVEVRT VNEEVYKAKY VILAIPPGLN LKIHFNPELP PLRNQLIHRV PMGSVIKCMV
310 320 330 340 350 360
YYKENFWRKK GYCGSMVIEE EDAPIGLTLD DTKPDGSVPA IMGFILARKS RKLANLTRDE
370 380 390 400 410 420
RKRRICEIYA RVLGSEEALY PVHYEEKNWC EEEYSGGCYT AYFPPGIMTQ FGRVLREPVG
430 440 450 460 470 480
RLYFAGTETA TEWSGYMEGA VQAGERASRE VMCAMGKLHA SQIWQSEPES MDVPARPFVT
490 500 510 520
TFWERNLPSV GGFLKFMGVS SFLAAATAAG LVACKKGLLP RC
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Q6NSN2 in FASTA format |
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