[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. TISSUE=Embryo; NIH - Xenopus Gene Collection (XGC) project; Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).
CATALYTIC ACTIVITY: 2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO₂.
COFACTOR: Thiamine pyrophosphate (By similarity).
SUBCELLULAR LOCATION: Mitochondrion (Potential).
SIMILARITY: Belongs to the alpha-ketoglutarate dehydrogenase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

BC064683; AAH64683.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_001084395.1; -.

UniGene

Xl.4843

3D structure databases

ModBase

Q6P286.

Family and domain databases

InterPro

IPR011603; 2oxoglutarate_DHase_E1.
IPR001017; DHase_E1.
IPR005475; Transketo_Cen_R.
Graphical view of domain structure.

PANTHER

PTHR23152; 2oxoglutarate_DH_E1; 1.

Pfam

PF00676; E1_dh; 1.
PF02779; Transket_pyr; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF000157; Oxoglu_dh_E1; 1.

TIGRFAMs

TIGR00239; 2oxo_dh_E1; 1.

BLOCKS

Q6P286.

Genome annotation databases

GeneID

403360; -.

KEGG

xla:403360; -.

Phylogenomic databases

HOVERGEN

Q6P286; -.

Other

ProtoNet

Q6P286.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Glycolysis; Mitochondrion; Oxidoreductase; Thiamine pyrophosphate; Transit peptide.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`TRANSIT`	`1 ?`		`Mitochondrion (Potential).`
`CHAIN`	`? 927`		`Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial.`	`PRO_0000307941`

Sequence information

Length: 927 AA [This is the length of the unprocessed precursor]

Molecular weight: 104104 Da [This is the MW of the unprocessed precursor]

CRC64: 43AEFD67A73A0EF3 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MNVFAHRCSS CRRAVVLWRP GLHRLYRTER GVYGYRPKIS AGSQLQESST RGKQAASPTV 

        70         80         90        100        110        120 
DHGLARLVTA YREHGHKAAK INPLFTGQAV MDMVPEIQEI MEILHGPFST TGLLNMGKSE 

       130        140        150        160        170        180 
ATIEEVLAYL DHTYCGQISI ETSQLQNYKE REWFSRRFEE LKQESFSTEE RKHLARLMLE 

       190        200        210        220        230        240 
CQEFDHFLAT KFSTVKRYGG EGAESMMGFF HEMLKMCSFG GVTDVIIGMP HRGRLNLLTG 

       250        260        270        280        290        300 
LLQFPPELMF RKMRGLSEFP ENSPSIGDVL SHLTSSVDLD FGSHRPLHVT MLPNPSHLEA 

       310        320        330        340        350        360 
INPVAVGKTR ARQQSLSDGD YSTESSAQPG DKVVCLQVHG DASISGQGIV TETFTLSNLP 

       370        380        390        400        410        420 
HYRIGGSIHL IVNNQLGYTT PAERGRSSLY SSDVGKIVGC AVIHVNGDDP EEVLRATRLA 

       430        440        450        460        470        480 
VEYQRCFRKD VIIDLLCYRQ WGHNELDEPF FTNPSMYKII RSRKSIPDVY SERLIAEGLM 

       490        500        510        520        530        540 
TEEEATEIRT TYYSKFNDHL SNMTLYSPPS TNLQAHWREM IEPSARTTTW DTGLPADLLK 

       550        560        570        580        590        600 
FIGAKSVEVP EEFKMHSHLL KMHAQSRVQK LQEATKLDWA TAEALAFGSL LCQGFNIRIS 

       610        620        630        640        650        660 
GQDVGRGTFS QRHAMLVCQE TNDTYIPLNH MTPDQKGFLE VSNSALSEEA VLGFEYGMSI 

       670        680        690        700        710        720 
ESPKLLPIWE AQFGDFFNGA QIIFDTFISG GEAKWLLQSG IVILLPHGYD GAGPEHSSCR 

       730        740        750        760        770        780 
IERFLQMCDS TEEGVDGDTV NMFVVHPTTP AQYFHLLRRQ MVRSFRKPLI VASPKMLLRY 

       790        800        810        820        830        840 
PAAVSSLEDI APGKTFRSVI GDSSADPKSV SKVILCSGKH YYALHKQREA LGEQGRSSAI 

       850        860        870        880        890        900 
IRVEELCPFP LEALQQEIHR YPKAKDFIWS QEEPQNMGAW TFVAPRFEKQ LACKLRLVSR 

       910        920 
PALPAPAVGI GTLHQQQQEE ITVKTLS

Q6P286 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools