[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. TISSUE=Kidney; NIH - Xenopus Gene Collection (XGC) project; Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (By similarity).
CATALYTIC ACTIVITY: Succinate + ubiquinone = fumarate + ubiquinol.
COFACTOR: FAD (By similarity).
PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle .
SUBUNIT: Component of complex II composed of four subunits: the flavoprotein (FP) sdha, iron-sulfur protein (IP) sdhb, and a cytochrome b560 composed of sdhc and sdhd (By similarity).
SUBCELLULAR LOCATION: Mitochondrion inner membrane; Peripheral membrane protein; Matrix side (By similarity).
SIMILARITY: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

BC060446; AAH60446.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_001083473.1; -.

UniGene

Xl.83156

3D structure databases

HSSP

P00363; 1KF6. [HSSP ENTRY / PDB]

SMR

Q6PA58; 56-665.

ModBase

Q6PA58.

Ontologies

GO:0005743;	Cellular component: mitochondrial inner membrane (inferred from electronic annotation from UniProtKB-SubCell).
GO:0008177;	Molecular function: succinate dehydrogenase (ubiquinone) activity (inferred from electronic annotation from EC).
QuickGo view.

Family and domain databases

InterPro

IPR003953; FAD_bind2_N.
IPR013027; FAD_pyr_nucl-diS_OxRdtase.
IPR003952; FRD_SDH_FAD_BS.
IPR004112; Fum_Rdtase/Succ_DHase_flav_C.
IPR001100; Pyr_nuc-diS_OxRdtase.
IPR011281; Succ_DHase_flav_su_fwd.
IPR014006; Succ_Dhase_frdA_Gneg.
Graphical view of domain structure.

Pfam

PF00890; FAD_binding_2; 1.
PF02910; Succ_DH_flav_C; 1.
Pfam graphical view of domain structure.

PRINTS

PR00368; FADPNR.
PR00411; PNDRDTASEI.

TIGRFAMs

TIGR01816; sdhA_forward; 1.
TIGR01812; sdhA_frdA_Gneg; 1.

PROSITE

PS00504; FRD_SDH_FAD_BINDING; 1.

BLOCKS

Q6PA58.

Genome annotation databases

GeneID

398946; -.

KEGG

xla:398946; -.

Phylogenomic databases

HOVERGEN

Q6PA58; -.

Other

ProtoNet

Q6PA58.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Electron transport; FAD; Flavoprotein; Membrane; Mitochondrion; Mitochondrion inner membrane; Oxidoreductase; Transit peptide; Transport; Tricarboxylic acid cycle.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`TRANSIT`	`1 43`	`43`	`Mitochondrion (Potential).`
`CHAIN`	`44 665`	`622`	`Succinate dehydrogenase [ubiquinone] flavoprotein subunit A, mitochondrial.`	`PRO_0000272305`
`NP_BIND`	`94 109`	`16`	`FAD (By similarity).`
`ACT_SITE`	`343 343`		`Proton acceptor (By similarity).`
`BINDING`	`299 299`		`Substrate (By similarity).`
`BINDING`	`311 311`		`Substrate (By similarity).`
`BINDING`	`410 410`		`Substrate (By similarity).`
`BINDING`	`454 454`		`Substrate (By similarity).`
`MOD_RES`	`102 102`		`Tele-8alpha-FAD histidine (By similarity).`

Sequence information

Length: 665 AA [This is the length of the unprocessed precursor]

Molecular weight: 72854 Da [This is the MW of the unprocessed precursor]

CRC64: 2C5F88CABBE479D5 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MALLKVAPSR LLSRALQLAS RVQNCTPTVT TARRNFHFTV YGRKDTSAKV SDSISTQYPV 

        70         80         90        100        110        120 
VDHEFDAVVV GAGGAGLRAA FGLSEAGFNT ACITKLFPTR SHTVAAQGGI NAALGNMEDD 

       130        140        150        160        170        180 
DWRWHFYDTV KGSDWLGDQD AIHYMTEQAP ASVIELENYG MPFSRTEQGK IYQRAFGGQS 

       190        200        210        220        230        240 
LKYGKGGQAH RCCCVADRTG HSLLHTLYGR SLRYDTSYFV EYFALDLLME NGECRGVIAL 

       250        260        270        280        290        300 
CMEDGSIHRF RAKNTVIATG GYGRTFFSCT SAHTSTGDGT AMVTRAGLPC QDLEFVQFHP 

       310        320        330        340        350        360 
TGIYGAGCLI TEGCRGEGGI LINSEGERFM ERYAPVAKDL ASRDVVSRSM TIEIREGRGC 

       370        380        390        400        410        420 
GKDKDHVYLQ LHHLPPSQLA SRLPGISETA MIFAGVDVTK EPIPVLPTVH YNMGGIPTNY 

       430        440        450        460        470        480 
KGQVITHVNG EDRVVPGLYS CGEAASASVH GANRLGANSL LDLVVFGRAC ALSIAESCKP 

       490        500        510        520        530        540 
GEAVPSIKEN AGEESVANLD KLRYANGSTR TSEIRINMQK TMQNHAAVFR TGSVLKEGCE 

       550        560        570        580        590        600 
KLSVINSSMD DIKTFDRGIV WNTDLVETLE LQNLMLCALQ TINGAEARKE SRGAHAREDY 

       610        620        630        640        650        660 
KVRIDEYDFS KPLQGQQKKS FNEHWRKHTL SYVDKKGKVS LEYRPVIDTT LNEDCASVPP 


AIRSY

Q6PA58 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools