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UniProtKB/Swiss-Prot entry Q6PDY2


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name AEDO_MOUSE
Primary accession number Q6PDY2
Secondary accession number Q3U2E1
Integrated into Swiss-Prot on October 11, 2004
Sequence was last modified on February 21, 2006 (Sequence version 2)
Annotations were last modified on    September 2, 2008 (Entry version 37)
Name and origin of the protein
Protein name 2-aminoethanethiol dioxygenase
Synonyms EC 1.13.11.19
Cysteamine dioxygenase
Gene name
Name: Ado
Synonyms: Gm237
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=NOD;
TISSUE=Dendritic cell;
DOI=10.1126/science.1112014; PubMed=16141072 [NCBI, ExPASy, EBI, Israel, Japan]
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J., Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6;
TISSUE=Brain;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
CATALYTIC ACTIVITY, COFACTOR, AND TISSUE SPECIFICITY.
DOI=10.1074/jbc.M703089200; PubMed=17581819 [NCBI, ExPASy, EBI, Israel, Japan]
Dominy J.E. Jr., Simmons C.R., Hirschberger L.L., Hwang J., Coloso R.M., Stipanuk M.H.;
"Discovery and characterization of a second mammalian thiol dioxygenase, cysteamine dioxygenase.";
J. Biol. Chem. 282:25189-25198(2007).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AK155334; BAE33200.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC057106; AAH57106.1; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC058407; AAH58407.1; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_001005419.1; -.
UniGene Mm.297250
3D structure databases
ModBase Q6PDY2.
PTM databases
PhosphoSite Q6PDY2; -.
Organism-specific databases
MGI MGI:2685083; Ado.
Gene expression databases
ArrayExpress Q6PDY2; -.
CleanEx MM_ADO; -.
GermOnline ENSMUSG00000057134; Mus musculus.
Family and domain databases
InterPro IPR012864; DUF1637.
Graphical view of domain structure.
PANTHER PTHR22966; DUF1637; 1.
Pfam PF07847; DUF1637; 1.
Pfam graphical view of domain structure.
BLOCKS Q6PDY2.
Genome annotation databases
Ensembl ENSMUSG00000057134; Mus musculus. [Contig view]
GeneID 211488; -.
KEGG mmu:211488; -.
Phylogenomic databases
HOGENOM Q6PDY2; -.
HOVERGEN Q6PDY2; -.
Other
SOURCE Ado; Mus musculus.
ProtoNet Q6PDY2.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Dioxygenase; Iron; Metal-binding; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom To Length Description FTId
CHAIN   1   256  256     2-aminoethanethiol dioxygenase. PRO_0000089785
Sequence information
Length: 256 AA [This is the length of the unprocessed precursor] Molecular weight: 28372 Da [This is the MW of the unprocessed precursor] CRC64: C5E23C4A72A79678 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MPRDNMASLI QRIARQACLT FRGSSTGSEG PAPGFPENLS LLKSLLTQVR AEDLNIAPRK 

        70         80         90        100        110        120 
ALPQPLPRNL PPVTYMHIYE TEGFSLGVFL LKSGTCIPLH DHPGMHGMLK VLYGTVRISC 

       130        140        150        160        170        180 
MDKLDTGAGH RRPPPEQQFE PPLQPLEREA VRPGVLRSRA EYTEASGPCV LTPHRDNLHQ 

       190        200        210        220        230        240 
IDAVDGPAAF LDILAPPYDP EDGRDCHYYR VVEPIRPKEA SGSACDLPRE VWLLETPQAD 

       250 
DFWCEGEPYP GPKVLP 

Q6PDY2 in FASTA format

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