[1]	NUCLEOTIDE SEQUENCE [MRNA]. Bai C.Y., Zhao W., Meng H., Pan Y.C.; "Cloning of the porcine MAO-A and -B gene."; Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine (By similarity).
CATALYTIC ACTIVITY: RCH₂NH₂ + H₂O + O₂ = RCHO + NH₃ + H₂O₂.
COFACTOR: FAD (By similarity).
SUBUNIT: Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer (By similarity).
SUBCELLULAR LOCATION: Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side (By similarity).
SIMILARITY: Belongs to the flavin monoamine oxidase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AY596820; AAT06259.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_001001864.1; -.

UniGene

Ssc.7297

3D structure databases

SMR

Q6PLK3; 2-500, 3-501.

ModBase

Q6PLK3.

Family and domain databases

InterPro

IPR001613; Amineoxid_fl.
IPR002937; Amino_oxidase.
Graphical view of domain structure.

Pfam

PF01593; Amino_oxidase; 1.
Pfam graphical view of domain structure.

PRINTS

PR00757; AMINEOXDASEF.

BLOCKS

Q6PLK3.

Genome annotation databases

GeneID

414909; -.

KEGG

ssc:414909; -.

Phylogenomic databases

HOVERGEN

Q6PLK3; -.

Other

ProtoNet

Q6PLK3.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Acetylation; FAD; Flavoprotein; Membrane; Mitochondrion; Mitochondrion outer membrane; Oxidoreductase; Transmembrane.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`INIT_MET`	`1 1`		`Removed (By similarity).`
`CHAIN`	`2 520`	`519`	`Amine oxidase [flavin-containing] B.`	`PRO_0000099861`
`TOPO_DOM`	`2 489`	`488`	`Cytoplasmic (By similarity).`
`TRANSMEM`	`490 516`	`27`	`Anchor for type IV membrane protein (By similarity).`
`TOPO_DOM`	`517 520`	`4`	`Mitochondrial intermembrane (By similarity).`
`COMPBIAS`	`36 52`	`17`	`Arg/Lys-rich (basic).`
`SITE`	`156 156`	`1`	`Important for catalytic activity (By similarity).`
`SITE`	`365 365`	`1`	`Important for catalytic activity (By similarity).`
`SITE`	`382 382`	`1`	`Important for catalytic activity (By similarity).`
`MOD_RES`	`2 2`		`N-acetylserine (By similarity).`
`MOD_RES`	`52 52`		`N6-acetyllysine (By similarity).`
`MOD_RES`	`397 397`		`S-8alpha-FAD cysteine (By similarity).`

Sequence information

Length: 520 AA [This is the length of the unprocessed precursor]

Molecular weight: 58265 Da [This is the MW of the unprocessed precursor]

CRC64: 18106D07B6151357 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSSKCDVVVV GGGISGMAAA KLLHDSGLNV IVLEARDRVG GRTYTVRNQQ VKYVDLGGSY 

        70         80         90        100        110        120 
VGPTQNRILR LSKELGLETY KVNEVERLIH YVKGKSYPFR GPLPPVRNPI TFLDLNNLWR 

       130        140        150        160        170        180 
TVDDMGREIP SDAPWKAPLA EQWDQMTMKE LLDKLCWTES SKQLATLFVN LCVTAETHEV 

       190        200        210        220        230        240 
SALWFLWYVK QCGGTTRIIS TTNGGQERKF VGGSGQVTER IKDLLGDRVK LERPVVHIDQ 

       250        260        270        280        290        300 
TGENVLVETL NHEVYEAKYV ISAIPPVLGM KIHFSPPLPM MRNQLITRVP LGSVIKCIVY 

       310        320        330        340        350        360 
YKEPFWRHKD YCGSMIIEGE EAPIAYTLDD SKPDGSCAAI IGFILAHKAR KLARLTKEER 

       370        380        390        400        410        420 
LKKLCDLYAK VLGSKEALNP VHYEEKNWCE EQYSAGCYTT YFPPGIMTQY GRVLRQPVGR 

       430        440        450        460        470        480 
IYFAGTETAT HWSGYMEGAV EAGERAAREI LHAMGKIPED EIWQSEPESV DVPAKPITTT 

       490        500        510        520 
FLERHLPSVP GLLRLIGLTA IFSATALGYL AHKRGLLVRV

Q6PLK3 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools