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[1]
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NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Sprague-Dawley;
TISSUE=Liver;
DOI=10.1038/nature02214; PubMed=14765194 [NCBI, ExPASy, EBI, Israel, Japan]
Rost S.,
Fregin A.,
Ivaskevicius V.,
Conzelmann E.,
Hoertnagel K.,
Pelz H.-J.,
Lappegard K.,
Seifried E.,
Scharrer I.,
Tuddenham E.G.D.,
Mueller C.R.,
Strom T.M.,
Oldenburg J.;
"Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2.";
Nature 427:537-541(2004).
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[2]
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MUTAGENESIS OF CYS-132 AND CYS-135.
DOI=10.1074/jbc.M413982200; PubMed=15640149 [NCBI, ExPASy, EBI, Israel, Japan]
Wajih N.,
Sane D.C.,
Hutson S.M.,
Wallin R.;
"Engineering of a recombinant vitamin K-dependent (gamma)-carboxylation system with enhanced (gamma)-carboxyglutamic acid forming capacity: evidence for a functional CxxC redox center in the system.";
J. Biol. Chem. 280:10540-10547(2005).
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- FUNCTION: Involved in vitamin K metabolism. Catalytic subunit of the vitamin K epoxide reductase (VKOR) complex which reduces inactive vitamin K 2,3-epoxide to active vitamin K.
- CATALYTIC ACTIVITY: 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol = 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol.
- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity).
- MISCELLANEOUS: The location of two cysteine active-site residues within a proposed transmembrane is consistent both with the known hydrophobic environment of the thiol redox site of the enzyme and with the lipophilicity of vitamin K and warfarin.
- SIMILARITY: Belongs to the VKOR family.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 161 AA [This is the length of the unprocessed precursor] |
Molecular weight: 17783 Da [This is the MW of the unprocessed precursor] |
CRC64: BBCE9897B00807DD [This is a checksum on the sequence] |
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10 20 30 40 50 60
MGTTWRSPGR LRLALCLAGL ALSLYALHVK AARARNEDYR ALCDVGTAIS CSRVFSSRWG
70 80 90 100 110 120
RGFGLVEHVL GADSILNQSN SIFGCMFYTI QLLLGCLRGR WASILLILSS LVSVAGSLYL
130 140 150 160
AWILFFVLYD FCIVCITTYA INAGLMLLSF QKVPEHKVKK P
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Q6TEK4 in FASTA format |
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