[1]	NUCLEOTIDE SEQUENCE [MRNA]. TISSUE=Venom gland; Soares A.M., Kashima S., Roberto P.G., Astolfi-Filho S., Pereira J.O., Giglio J.R., Franca S.C.; "Structural and functional characterization of L-amino acid oxidase from Bothrops moojeni snake venom."; Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
[2]	FUNCTION, AND SUBUNIT. TISSUE=Venom; DOI=10.1006/bbrc.2000.4175; PubMed=11162565 [NCBI, ExPASy, EBI, Israel, Japan] Tempone A.G., Andrade H.F. Jr., Spencer P.J., Lourenco C.O., Rogero J.R., Nascimento N.; "Bothrops moojeni venom kills Leishmania spp. with hydrogen peroxide generated by its L-amino acid oxidase."; Biochem. Biophys. Res. Commun. 280:620-624(2001).

Comments

FUNCTION: Catalyzes an oxidative deamination of predominantly hydrophobic and aromatic L-amino acids. Inhibits platelet aggregation. Has an ability to induce apoptosis and hemorrhage. Has an antibacterial activity (By similarity). Presents a killing effect in vitro against Leishmania spp promastigotes, but not with amastigotes.
CATALYTIC ACTIVITY: An L-amino acid + H₂O + O₂ = a 2-oxo acid + NH₃ + H₂O₂.
COFACTOR: FAD (By similarity).
SUBUNIT: Homodimer.
SUBCELLULAR LOCATION: Secreted (By similarity).
TISSUE SPECIFICITY: Expressed by the venom gland.
PTM: Glycosylated (By similarity).
SIMILARITY: Belongs to the flavin monoamine oxidase family. FIG1 subfamily.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AY398692; AAR31183.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

SMR

Q6TGQ8; 10-477.

ModBase

Q6TGQ8.

Family and domain databases

InterPro

IPR000759; Adrndx_reductase.
IPR001613; Amineoxid_fl.
IPR002937; Amino_oxidase.
IPR013027; FAD_pyr_nucl-diS_OxRdtase.
Graphical view of domain structure.

Pfam

PF01593; Amino_oxidase; 1.
Pfam graphical view of domain structure.

PRINTS

PR00419; ADXRDTASE.
PR00757; AMINEOXDASEF.
PR00368; FADPNR.

ProDom

PD000139; FAD_pyr_redox; 1.
[Domain structure / List of seq. sharing at least 1 domain]

BLOCKS

Q6TGQ8.

Phylogenomic databases

HOVERGEN

Q6TGQ8; -.

Other

ProtoNet

Q6TGQ8.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Antibiotic; Antimicrobial; Apoptosis; Blood coagulation; FAD; Flavoprotein; Glycoprotein; Oxidoreductase; Secreted; Signal; Toxin.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`<1 6`	`>6`	`By similarity.`
`CHAIN`	`7 >478`	`>472`	`L-amino-acid oxidase.`	`PRO_0000273565`
`NP_BIND`	`95 96`	`2`	`FAD (By similarity).`
`NP_BIND`	`472 475`	`4`	`FAD (By similarity).`
`BINDING`	`50 50`		`FAD (By similarity).`
`BINDING`	`69 69`		`FAD (By similarity).`
`BINDING`	`77 77`		`FAD (By similarity).`
`BINDING`	`96 96`		`Substrate (By similarity).`
`BINDING`	`229 229`		`Substrate (By similarity).`
`BINDING`	`267 267`		`FAD; via amide nitrogen and carbonyl oxygen (By similarity).`
`BINDING`	`378 378`		`Substrate (By similarity).`
`BINDING`	`463 463`		`FAD (By similarity).`
`CARBOHYD`	`178 178`		`N-linked (GlcNAc...) (Potential).`
`DISULFID`	`16 179`		`By similarity.`
`DISULFID`	`337 418`		`By similarity.`
`NON_TER`	`1 1`
`NON_TER`	`478 478`

Sequence information

Length: 478 AA [This is the length of the partial sequence of the unprocessed precursor]

Molecular weight: 54437 Da [This is the MW of the partial sequence of the unprocessed precursor]

CRC64: 555C159B029FB9CB [This is a checksum on the sequence]

        10         20         30         40         50         60 
RKAPCCADDR NPLEECFRET DYEEFLEIAK NGLSTTSNPK RVVIVGAGMS GLSAAYVLAN 

        70         80         90        100        110        120 
AGHQVTVLEA SERAGGRVKT YRNEKEGWYA NLGPMRLPEK HRIVREYIRK FDLQLNEFSQ 

       130        140        150        160        170        180 
ENENAWYFIK NIRKRVGEVN KDPGVLEYPV KPSEVGKSAG QLYEESLQKA VEELRRTNCS 

       190        200        210        220        230        240 
YMLNKYDTYS TKEYLLKEGN LSPGAVDMIG DLLNEDSGYY VSFIESLKHD DIFAYEKRFD 

       250        260        270        280        290        300 
EIVGGMDKLP TSMYQAIQEK VHLNARVIKI QQDVKEVTVT YQTSEKETLS VTADYVIVCT 

       310        320        330        340        350        360 
TSRAARRIKF EPPLPPKKAH ALRSVHYRSG TKIFLTCTKK FWEDDGIHGG KSTTDLPSRF 

       370        380        390        400        410        420 
IYYPNHNFPN GVGVIIAYGI GDDANYFQAL DFEDCGDIVI NDLSLIHQLP KEEIQAICRP 

       430        440        450        460        470 
SMIQRWSLDK YAMGGITTFT PYQFQHFSEA LTAPVDRIYF AGEYTAQAHG WIDSTIKW

Q6TGQ8 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools