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[1]
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NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nbt956; PubMed=15064768 [NCBI, ExPASy, EBI, Israel, Japan]
Henne A.,
Brueggemann H.,
Raasch C.,
Wiezer A.,
Hartsch T.,
Liesegang H.,
Johann A.,
Lienard T.,
Gohl O.,
Martinez-Arias R.,
Jacobi C.,
Starkuviene V.,
Schlenczeck S.,
Dencker S.,
Huber R.,
Klenk H.-P.,
Kramer W.,
Merkl R.,
Gottschalk G.,
Fritz H.-J.;
"The genome sequence of the extreme thermophile Thermus thermophilus.";
Nat. Biotechnol. 22:547-553(2004).
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- FUNCTION: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient required for the synthesis of ATP. The role of the nqo9 subunit appears to provide a 'connecting chain' of two clusters between cluster N5 and the terminal cluster N2, and to stabilize the structure of the complex by interacting with other subunits (By similarity).
- CATALYTIC ACTIVITY: NADH + quinone = NAD+ + quinol.
- COFACTOR: Binds 2 4Fe-4S clusters per subunit (By similarity).
- SUBUNIT: NDH-1 is composed of 15 different subunits, nqo1 to nqo15. The complex has a L-shaped structure, with the hydrophobic arm (subunits nqo7, nqo8 and nqo10 to nqo14) embedded in the membrane and the hydrophilic peripheral arm (subunits nqo1 to nqo6, nqo9 and nqo15) protruding into the bacterial cytoplasm. The hydrophilic domain contains all the redox centers (By similarity).
- SUBCELLULAR LOCATION: Cell inner membrane; Peripheral membrane protein (Potential).
- SIMILARITY: Belongs to the complex I 23 kDa subunit family.
- SIMILARITY: Contains 2 4Fe-4S ferredoxin-type domains.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 182 AA [This is the length of the unprocessed precursor] |
Molecular weight: 20080 Da [This is the MW of the unprocessed precursor] |
CRC64: 054A9F7942C64C66 [This is a checksum on the sequence] |
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10 20 30 40 50 60
MTLKALAQSL GITLKYLFSK PVTVPYPDAP VALKPRFHGR HVLTRHPNGL EKCIGCSLCA
70 80 90 100 110 120
AACPAYAIYV EPAENDPENP VSAGERYAKV YEINMLRCIF CGLCEEACPT GAIVLGYDFE
130 140 150 160 170 180
MADYEYSDLV YGKEDMLVDV VGTKPQRREA KRTGKPVKVG YVVPYVRPEL EGFKAPTEGG
KR
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Q72GD6 in FASTA format |
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