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UniProtKB/Swiss-Prot entry Q74ZK4

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name GSHR_ASHGO
Primary accession number Q74ZK4
Secondary accession numbers None
Integrated into Swiss-Prot on October 11, 2004
Sequence was last modified on July 5, 2004 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 26)
Name and origin of the protein
Protein name Glutathione reductase
Synonyms GRase
GR
EC 1.8.1.7
Gene name
Name: GLR1
OrderedLocusNames: AGR196W
From
Ashbya gossypii (Yeast) (Eremothecium gossypii) [TaxID: 33169] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Eremothecium.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 10895 / NRRL Y-1056 / CBS 109.51;
DOI=10.1126/science.1095781; PubMed=15001715 [NCBI, ExPASy, EBI, Israel, Japan]
Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S., Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A., Gaffney T.D., Philippsen P.;
"The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome.";
Science 304:304-307(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE016820; AAS54686.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_986862.1; -.
3D structure databases
ModBase Q74ZK4.
Organism-specific databases
AGD AGR196W; -.
Family and domain databases
InterPro IPR013027; FAD_pyr_nucl-diS_OxRdtase.
IPR006322; Glut_reduct_1.
IPR000815; Hg_reductase.
IPR001100; Pyr_nuc-diS_OxRdtase.
IPR004099; Pyr_nucl-diS_OxRdtase_dimer.
IPR012999; Pyr_OxRdtase_I_AS.
IPR001327; Pyr_OxRdtase_NAD_bd.
Graphical view of domain structure.
Gene3D G3DSA:3.30.390.30; Pyr_redox_dim; 1.
Pfam PF00070; Pyr_redox; 1.
PF07992; Pyr_redox_2; 1.
PF02852; Pyr_redox_dim; 1.
Pfam graphical view of domain structure.
PRINTS PR00368; FADPNR.
PR00945; HGRDTASE.
PR00411; PNDRDTASEI.
ProDom PD000139; FAD_pyr_redox; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR01421; gluta_reduc_1; 1.
PROSITE PS00076; PYRIDINE_REDOX_1; 1.
BLOCKS Q74ZK4.
Genome annotation databases
GeneID 4623164; -.
KEGG ago:AGOS_AGR196W; -.
NMPDR fig|33169.1.peg.4507; -.
Phylogenomic databases
HOGENOM Q74ZK4; -.
Other
ProtoNet Q74ZK4.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Cytoplasm; FAD; Flavoprotein; NADP; Oxidoreductase; Redox-active center.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   480  480     Glutathione reductase. PRO_0000067965
NP_BIND   51    59  9     FAD (By similarity). 
ACT_SITE   469   469        Proton acceptor (By similarity). 
DISULFID   59    64        Redox-active (By similarity). 
Sequence information
Length: 480 AA [This is the length of the unprocessed precursor] Molecular weight: 52649 Da [This is the MW of the unprocessed precursor] CRC64: 8AF0C57EEA727BC9 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MLRCREVYNI CKGAMSNEVK HYDYLVIGGG SGGVASSRRA ASYGAKTVLI EGKALGGTCV 

        70         80         90        100        110        120 
NVGCVPKKVM WYASDLAHRL LHARDYGLLQ EVDISKEKLH FNWKEFAGKR NAYVERLNGI 

       130        140        150        160        170        180 
YERNLAKEGV EYVHGWARFN SEGQVEVTRP DQTTEKYTAD HILIATGGEP VLPEGIPGAE 

       190        200        210        220        230        240 
YGVDSDGFFR LEEQPKKVVI SGSGYIATEF AGVFNGLGTE THIVIRKDHV LTKFDPSIQE 

       250        260        270        280        290        300 
IVTEHYEKEG VNIHKKESIQ RVEKDPNTGK LTVHLSGKII EDVDQLVWAI GRKSLLGIAP 

       310        320        330        340        350        360 
ENVGVKLGET GHVVVDEYQN TSTKGIYALG DVVGNMELTP VAIAAGRKLA NRLFGPEQMR 

       370        380        390        400        410        420 
AQKQDYDNVP SVVFSHPEAG SIGLTEPQAI ERYGKENIKI YQTKFTAMYY AMLEDKSPTK 

       430        440        450        460        470        480 
YKLICAGPEE KVVGLHIVGD GSAEILQGFG VAIKMGATKA DFDSCVAIHP TSAEEIVTLK
Q74ZK4 in FASTA format

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